Anticipation and the artificial: aesthetics, ethics, and synthetic life

If complexity is a necessary but not sufficient premise for the existence and expression of the living, anticipation is the distinguishing characteristic of what is alive. Anticipation is at work even at levels of existence where we cannot refer to intelligence. The prospect of artificially generating aesthetic artifacts and ethical constructs of relevance to a world in which the natural and the artificial are coexistent cannot be subsumed as yet another product of scientific and technological advancement. Beyond the artificial, the synthetic conjures the understanding of aesthetics and ethics no longer from the perspective of the How? type of question, but rather the Why? Given the current infatuation with synthetic biology (i.e., making life from non-life), there is a practical consequence to such considerations. Synthetic life, as any other form of life, implies the possibility of evolution. Anticipation, which is the underlying factor of evolution, is thus expected. At the level of human existence, anticipation is expressed, for instance (but not exclusively), in aesthetic forms and ethical values. This translates, in turn, into an argument for the role aesthetics and ethics play in the process. Consequently, to qualify as life, the synthesis of the physical and the living will have to efficiently handle ambiguity. Current computational facilities, regardless of their nature or performance, operate exclusively in the semiotic domain of the well defined non-ambiguous.     

Properties of X-, C- and L-band repeat-pass interferometric SAR coherence in Mediterranean pine forests affected by fires

Synthetic Aperture Radar (SAR) data has been investigated to determine the relationship between burn severity and interferometric coherence at three sites affected by forest fires in a hilly Mediterranean environment. Repeat-pass SAR images were available from the TerraSAR-X, ERS-1/2, Envisat ASAR and ALOS PALSAR sensors. Coherence was related to measurements of burn severity (Composite Burn Index) and remote sensing estimates expressed by the differenced normalized burn ratio (dNBR) index. In addition, the effects of topography and weather on coherence estimates were assessed. The analysis for a given range of local incidence angle showed that the co-polarized coherence increases with the increase of burn severity at X- and C-band whereas cross-polarized coherence was practically insensitive to burn severity. Higher sensitivity to burn severity was found at L-band for both co- and cross-polarized channels. The association strength between coherence and burn severity was strongest for images acquired under stable, dry environmental conditions. When the local incidence angle is accounted for the determination coefficients increased from 0.6 to 0.9 for X- and C-band. At L-band the local incidence angle had less influence on the association strength to burn severity.     

Spiking neural P systems with extended rules: universality and languages

We consider spiking neural P systems with rules allowed to introduce zero, one, or more spikes at the same time. The motivation comes both from constructing small universal systems and from generating strings; previous results from these areas are briefly recalled. Then, the computing power of the obtained systems is investigated, when considering them as number generating and as language generating devices. In the first case, a simpler proof of universality is obtained, while in the latter case we find characterizations of finite and recursively enumerable languages (without using any squeezing mechanism, as it was necessary in the case of standard rules). The relationships with regular languages are also investigated.     

Null controllability of an infinite dimensional SDE with state- and control-dependent noise

We consider a controlled stochastic linear differential equation with state- and control-dependent noise in a Hilbert space H. We investigate the relation between the null controllability of the equation and the existence of the solution of “singular” Riccati operator equations. Moreover, for a fixed interval of time, the null controllability is characterized in terms of the dual state. Examples of stochastic PDEs are also considered.     

Study on highly thermostable low-k polymer films based on fluorene-containing polyetherimides

Highly thermostable low-k polymer films with potential applications as dielectric materials in microelectronic industry were synthesized starting from 9,9-bis[4-(3,4-dicarboxyphenoxy)phenyl]fluorene dianhydride and various diamines. A polyetherimide/silica nanocomposite film was obtained using methyltriethoxysilane as precursor of inorganic phase. The chemical structure was confirmed by FTIR and ¹H NMR spectroscopy. Water vapor's sorption capacity, thermal stability, glass transition temperature, thermal diffusivity, specific heat, thermal conductivity, and dielectric characteristics of the films were determined. All the films exhibited excellent thermal stability, with an initial decomposition temperature in the range of 500–530°C. They showed low dielectric constant of 1.98–2.86 and low dielectric loss of 0.0037–0.011, at a frequency of 1 Hz and room temperature. The subglass γ- and β-relaxations, primary α-relaxation, and conductivity relaxation processes were discussed according to the chemical structure of the samples. Quantitative structure–property relationship (QSPR) study was conducted, and linear regression models were formulated to describe the causal relationships between different parameters and polyetherimide properties.     

Cohesive Modeling of Fracture in Asphalt Mixtures at Low Temperatures

Low temperature cracking is the major distress observed in asphalt pavements in the northern US and Canada. In the past years fracture mechanics concepts were introduced to investigate the fracture properties of asphalt mixtures at low temperatures. In this paper the cohesive zone model (CZM) is used to describe the fracture behavior of asphalt mixtures at low temperatures and the interface element is used to numerically simulate the material response under monotonic loading. The simulation is calibrated with the experimental results from a newly proposed semi circular bend (SCB) test. A parametric analysis of the input material properties indicates that the tensile strength has a significant effect on the peak load in the SCB configuration, the modulus has a strong effect on the calculated stiffness of the SCB specimen, and the fracture energy influences the post-peak behavior of the asphalt mixtures. The calibrated numerical model was applied to simulate the low temperature cracking in a simplified asphalt pavement and to study the influence of these material parameters on the performance of asphalt pavements.     

New Investigations with Lupane Type A-Ring Azepane Triterpenoids for Antimycobacterial Drug Candidate Design

Twenty lupane type A-ring azepano-triterpenoids were synthesized from betulin and its related derivatives and their antitubercular activity against Mycobacterium tuberculosis, mono-resistant MTB strains, and nontuberculous strains Mycobacterium abscessus and Mycobacterium avium were investigated in the framework of AToMIc (Anti-mycobacterial Target or Mechanism Identification Contract) realized by the Division of Microbiology and Infectious Diseases, NIAID, National Institute of Health. Of all the tested triterpenoids, 17 compounds showed antitubercular activity and 6 compounds were highly active on the H37Rv wild strain (with MIC 0.5 µM for compound 7), out of which 4 derivatives also emerged as highly active compounds on the three mono-resistant MTB strains. Molecular docking corroborated with a machine learning drug-drug similarity algorithm revealed that azepano-triterpenoids have a rifampicin-like antitubercular activity, with compound 7 scoring the highest as a potential M. tuberculosis RNAP potential inhibitor. FIC testing demonstrated an additive effect of compound 7 when combined with rifampin, isoniazid and ethambutol. Most compounds were highly active against M. avium with compound 14 recording the same MIC value as the control rifampicin (0.0625 µM). The antitubercular ex vivo effectiveness of the tested compounds on THP-1 infected macrophages is correlated with their increased cell permeability. The tested triterpenoids also exhibit low cytotoxicity and do not induce antibacterial resistance in MTB strains.     

Atmospheric Pressure Plasma Activation of Hydroxyapatite to Improve Fluoride Incorporation and Modulate Bacterial Biofilm

Despite the technological progress of the last decade, dental caries is still the most frequent oral health threat in children and adults alike. Such a condition has multiple triggers and is caused mainly by enamel degradation under the acidic attack of microbial cells, which compose the biofilm of the dental plaque. The biofilm of the dental plaque is a multispecific microbial consortium that periodically develops on mammalian teeth. It can be partially removed through mechanical forces by individual brushing or in specialized oral care facilities. Inhibition of microbial attachment and biofilm formation, as well as methods to strengthen dental enamel to microbial attack, represent the key factors in caries prevention. The purpose of this study was to elaborate a cold plasma-based method in order to modulate microbial attachment and biofilm formation and to improve the retention of fluoride (F⁻) in an enamel-like hydroxyapatite (HAP) model sample. Our results showed improved F retention in the HAP model, which correlated with an increased antimicrobial and antibiofilm effect. The obtained cold plasma with a dual effect exhibited through biofilm modulation and enamel strengthening through fluoridation is intended for dental application, such as preventing and treating dental caries and enamel deterioration.     

One-step synthesis of platinum nanoparticles loaded in alginate bubbles

Composite particles with multifunctions have been extensively utilized for various applications. Bubble particles can be applied for ultrasound-mediated imaging, drug delivery, absorbers, cell culture, etc. This study proposes a one-step strategy to obtain Pt nanoparticles loaded in alginate bubbles. A needle-based droplet formation was used to generate uniform alginate particles about 2 mm in diameter. The hydrolysis reaction of NaBH₄ was utilized to produce gaseous hydrogen and then trapped within alginate particles to form bubbles. The Pt⁴⁺ mixed with alginate solution was dropped into the reservoir to react with reducing NaBH₄ and hardening CaCl₂ to form Pt nanoparticles-alginate composite bubbles. Results indicate that the size of bubbles decreases with the CaCl₂ concentration (1% ~ 20%), and size of bubbles increases with the NaBH₄ concentration (1 ~ 20 mM). The advantages for the present approach include low cost, easy operation, and effective production of Pt nanoparticles-alginate composite bubbles.