Behavior of square concrete columns reinforced with Prefabricated Cage System

Behavior of normal strength concrete columns reinforced with a new reinforcement, termed Prefabricated Cage System (PCS) is investigated. A total of 16 small-scale PCS and rebar reinforced column specimens were constructed and tested under monotonic axial displacement. The experimental results indicate that the overall behavior of rebar and PCS reinforced specimens are comparable prior to achieving the peak column load. In general, PCS specimens are more ductile and absorb more energy than similar rebar specimens after the peak load is reached. The effect of different parameters, such as the steel tube thickness, number of longitudinal reinforcements, transverse steel spacing, and crossties on the specimens’ strength and deformation capacity are investigated. A confined concrete model is proposed and used to predict the load–displacement response. The theoretical load–displacement relations obtained from the proposed model are compared with those obtained from the Mander et al. (J Struct Eng 114(8):1804–1826, 1988) confinement model.     

Selection of the optimum decomposition level using the discrete wavelet transform for automobile suspension system

Journal of Mechanical Science and Technology - This paper discusses the determination of the optimum decomposition level by using the discrete wavelet transform (DWT) method for an automobile...     

Insight into the Impact of Oxidative Stress on the Barrier Properties of Lipid Bilayer Models

As a new field of oxidative stress-based therapy, cold physical plasma is a promising tool for several biomedical applications due to its potential to create a broad diversity of reactive oxygen and nitrogen species (RONS). Although proposed, the impact of plasma-derived RONS on the cell membrane lipids and properties is not fully understood. For this purpose, the changes in the lipid bilayer functionality under oxidative stress generated by an argon plasma jet (kINPen) were investigated by electrochemical techniques. In addition, liquid chromatography-tandem mass spectrometry was employed to analyze the plasma-induced modifications on the model lipids. Various asymmetric bilayers mimicking the structure and properties of the erythrocyte cell membrane were transferred onto a gold electrode surface by Langmuir-Blodgett/Langmuir-Schaefer deposition techniques. A strong impact of cholesterol on membrane permeabilization by plasma-derived species was revealed. Moreover, the maintenance of the barrier properties is influenced by the chemical composition of the head group. Mainly the head group size and its hydrogen bonding capacities are relevant, and phosphatidylcholines are significantly more susceptible than phosphatidylserines and other lipid classes, underlining the high relevance of this lipid class in membrane dynamics and cell physiology.     

Modeling metallurgical responses of coal Tri-Flo separators by a novel BNN:a "Conscious-Lab" development

Tri-flo cyclone,as a dense-medium separation device,is one of the most typical environmentally friendly industrial techniques in the coal washery plants.Surpris...     

Camelid Single-Domain Antibodies: Promises and Challenges as Lifesaving Treatments

Since the discovery of camelid heavy-chain antibodies in 1993, there has been tremendous excitement for these antibody domains (VHHs/sdAbs/nanobodies) as research tools, diagnostics, and therapeutics. Commercially, several patents were granted to pioneering research groups in Belgium and the Netherlands between 1996–2001. Ablynx was established in 2001 with the aim of exploring the therapeutic applications and development of nanobody drugs. Extensive efforts over two decades at Ablynx led to the first approved nanobody drug, caplacizumab (Cablivi) by the EMA and FDA (2018–2019) for the treatment of rare blood clotting disorders in adults with acquired thrombotic thrombocytopenic purpura (TPP). The relatively long development time between camelid sdAb discovery and their entry into the market reflects the novelty of the approach, together with intellectual property restrictions and freedom-to-operate issues. The approval of the first sdAb drug, together with the expiration of key patents, may open a new horizon for the emergence of camelid sdAbs as mainstream biotherapeutics in the years to come. It remains to be seen if nanobody-based drugs will be cheaper than traditional antibodies. In this review, I provide critical perspectives on camelid sdAbs and present the promises and challenges to their widespread adoption as diagnostic and therapeutic agents.     

Stability preservation analysis in direct discretization of fractional order transfer functions

In this paper, a class of the direct methods for discretization of fractional order transfer functions is studied in the sense of stability preservation. The stability boundary curve is exactly determined for these discretization methods. Having this boundary helps us to recognize whether the original system and its discretized model are the same in the sense of stability. Finally, some illustrative examples are presented to evaluate achievements of the paper.