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861.
The production of zeolite granules varies in the amounts of binder content and different drying/activation temperatures. Here, the influence of moisture content and cyclic moisture loading and unloading on the mechanical properties like the strength of three different types of zeolite granules has been studied by uniaxial compression tests. The force‐displacement curves and scanning electron microscopy pictures of the granule and fracture surfaces show that with increasing number of moistening‐drying cycles, a continuous decrease in the strength of granules take place due to non‐regenerative damage of the structure. 相似文献
862.
863.
2D Materials: The Influence of Water on the Optical Properties of Single‐Layer Molybdenum Disulfide (Adv. Mater. 17/2015) 下载免费PDF全文
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865.
High Broad‐Band Photoresponsivity of Mechanically Formed InSe–Graphene van der Waals Heterostructures 下载免费PDF全文
866.
Shari Sellers Walter Horodnik Aileen House Jennifer Wylie Peter Mauser Natalie Garber 《Drug development and industrial pharmacy》2015,41(12):1989-1996
AbstractContext: Aerosol delivery to animals in preclinical settings has historically been very challenging, requiring the use of techniques, such as intratracheal instillation and dry powder insufflation, that are somewhat invasive, inefficient and not representative of clinical inhalation.Objective: The objective of this work is to develop a system to deliver dry powder to dogs in an efficient and effective manner for the study of new anti-migraine compounds in development.Materials and methods: The new device uses a metered aliquot of a dry gas to force dry powder drug from a pre-filled HPMC capsule into an AeroChamber® spacer for subsequent inhalation by the animal.Results: The delivery of two invesigational migraine drugs via the new device was assessed in vitro using abbreviated Andersen cascade impaction and showed the device is capable of generating a reproducible delivered dose of up to ~68% with more than 50% of the dose in the respirable range. In vivo studies have also been performed showing that this device effectively delivered the migraine drugs to spontaneously breathing dogs using a proprietary validated dog inhalation model.Discussion: Results confirmed that the air pressurized capsule device (APCD) was effective in delivering the APIs to lungs of the animals. The in vivo data verified the advantages of inhaled delivery over oral delivery for this class of drugs and were used to establish the cardiopulmonary and respiratory side effect liability profile for these compounds.Conclusions: This work has demonstrated the utility of this device for quick and accurate screening of prospective drug candidates, representing a significant improvement in ease of use and reprodicibility over current delivery methods. 相似文献
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869.
The Effect of Gradual Fluorination on the Properties of FnZnPc Thin Films and FnZnPc/C60 Bilayer Photovoltaic Cells 下载免费PDF全文
Michael Brendel Stefan Krause Andreas Steindamm Anna Katharina Topczak Sudhakar Sundarraj Peter Erk Steffen Höhla Norbert Fruehauf Norbert Koch Jens Pflaum 《Advanced functional materials》2015,25(10):1565-1573
Motivated by the possibility of modifying energy levels of a molecule without substantially changing its band gap, the impact of gradual fluorination on the optical and structural properties of zinc phthalocyanine (FnZnPc) thin films and the electronic characteristics of FnZnPc/C60 (n = 0, 4, 8, 16) bilayer cells is investigated. UV–vis measurements reveal similar Q‐ and B‐band absorption of FnZnPc thin films with n = 0, 4, 8, whereas for F16ZnPc a different absorption pattern is detected. A correlation between structure and electronic transport is deduced. For F4ZnPc/C60 cells, the enhanced long range order supports fill factors of 55% and an increase of the short circuit current density by 18%, compared to ZnPc/C60. As a parameter being sensitive to the organic/organic interface energetics, the open circuit voltage is analyzed. An enhancement of this quantity by 27% and 50% is detected for F4ZnPc‐ and F8ZnPc‐based devices, respectively, and is attributed to an increase of the quasi‐Fermi level splitting at the donor/acceptor interface. In contrast, for F16ZnPc/C60 a decrease of the open circuit voltage is observed. Complementary photoelectron spectroscopy, external quantum efficiency, and photoluminescence measurements reveal a different working principle, which is ascribed to the particular energy level alignment at the interface of the photoactive materials. 相似文献
870.
Peter Buchanan 《Architectural Design》2015,85(2):88-93
The architecture of the Renzo Piano Building Workshop (RPBW) is renowned internationally for the formal refinement of its components and detailing as well as for its sensitive responses to context, both in terms of its physical surroundings and local construction traditions. But, as architectural author and Piano specialist Peter Buchanan reminds us, the central concern of the practice remains focused on the original core impetus of expandingthe bounds of what technology and materials can achieve. 相似文献