Population dose from natural radionuclides in phosphate fertilizers

The natural radionuclide content of mineral phosphate fertilizers has been determined gammaspectrometrically. The investigations comprised ca. 70% of the mineral phosphate fertilizers authorized and used in the Federal Republic of Germany (FRG). At maximum, we found specific activities of 62 nCi Unat/kg, 23 nCi 226Ra/kg, 1.6 nCi Thnat/kg and 262 nCi 40K/kg. The mean values, weighted by the percentual agricultural consumption of the main phosphate fertilizer groups in 1973/74 and related to the phosphate content, amounted to 58, 40, 2, and 584 nCi/kg P2O5 for Unat, 226Ra, Thnat, and 40K respectively. This resulted in an annual distribution due to phosphate fertilizing of about 3.9 muCi Unat, 2.7 muCi 226Ra, 0.1 muCi Thnat, and 39.9 muCi 40K per ha of arable or pasture land in 1973/74 on the average. From these values the air dose rates over agricultural areas have been estimated under extreme conservative assumptions resulting in an additional external exposure of members of the population of 0.02 mrd/a on the average and 0.4 mrd/a in the region of highest phosphate fertilizing intensity. If it is assumed that radium contained in phosphate fertilizers were completely accumulated in the soils during the last 80 years, this value would be raised to 0.3 mrd/a on the average. The occupational external radiation exposure due to natural radionuclides contained in phosphate fertilizers was estimated to be 0.1 mrd/a on the average and 2.3 mrd/a at maximum for persons working in agriculture. These estimates show that natural radionuclides in phosphate fertilizers contribute but very little to the mean terrestrial radiation exposure of the population which is 50 to 55 mrd/a in Germany. Only for the small group of persons working in fertilizer production plants or storehouses a significant increase of the external radiation exposure has to be expected which could reach a doubling of the mean natural exposure value.     

Environmental impacts of water use in global crop production: hotspots and trade-offs with land use

Global crop production is causing pressure on water and land resources in many places. In addition to local resource management, the related environmental impacts of commodities traded along international supply chains need to be considered and managed accordingly. For this purpose, we calculate the specific water consumption and land use for the production of 160 crops and crop groups, covering most harvested mass on global cropland. We quantify indicators for land and water scarcity with high geospatial resolution. This facilitates spatially explicit crop-specific resource management and regionalized life cycle assessment of processed products. The vast cultivation of irrigated wheat, rice, cotton, maize, and sugar cane, which are major sources of food, bioenergy, and fiber, drives worldwide water scarcity. According to globally averaged production, substituting biofuel for crude oil would have a lower impact on water resources than substituting cotton for polyester. For some crops, water scarcity impacts are inversely related to land resource stress, illustrating that water consumption is often at odds with land use. On global average, maize performs better than rice and wheat in the combined land/water assessment. High spatial variability of water and land use related impacts underlines the importance of appropriate site selection for agricultural activities.     

RS-17053 (N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-alpha, alpha-dimethyl-1H-indole-3-ethanamine hydrochloride), a selective alpha 1A-adrenoceptor antagonist, displays low affinity for functional alpha 1-adrenoceptors in human prostate: implications for adrenoceptor classification

Hereditary developmental abnormalities of the upper or lower limbs in humans are easily recognizable phenotypes that can be used in the mapping and cloning of genes involved in normal human development. We studied a large Indian pedigree (UR002) with an autosomal dominant triphalangeal thumb (TPT) and polysyndactyly (PSD). The abnormalities were present only in the upper limbs, and the phenotype was fully penetrant. The expression of the phenotype was variable and ranged from unilateral TPT to bilateral TPT, preaxial du-, tri-, or quadruplication of the thumb, or syndactyly of multiple thumbs. There were 112 affected individuals in the pedigree. Previous linkage analyses on apparently similar phenotypes have identified a locus at 7q36 [Heutink et al., 1994, Nature Genet 6:287-291; Tsukurov et al., 1994]. To map the gene responsible for the TPT-PSD in family UR002, we performed linkage analysis in DNA from 47 affected and 7 normal individuals. Marker D7S550, located at 7q36, yielded a maximum LOD score of 11.31 at theta = 0.00. Additional markers in the region also showed no recombination. These data indicate that the gene responsible for the hand abnormality in pedigree UR002 maps to the same region as that in previous pedigrees with similar phenotype. Further analyses of recombinants among all the linked families by using new polymorphic markers will narrow the critical genomic region and facilitate positional cloning of the elusive gene.     

High-dose edatrexate with oral leucovorin rescue: a phase I and clinical pharmacological study in adults with advanced cancer

Our objective was to determine the maximum tolerated dose and toxicity of i.v. edatrexate with p.o. leucovorin. Thirty-one adults with advanced solid tumors received edatrexate as a 2-h infusion, once a week for 3 weeks, recycled every 28 days. p.o. leucovorin (10 mg/m2, every 6 h for 10 doses) began 24 h later. All had urinary alkalinization and p.o. hydration. Nine dosage levels ranging from 120 to 3750 mg/m2 were explored. Fatigue, epistaxis, nausea/emesis, mucositis, rash, myalgias, leukopenia, thrombocytopenia, and transient elevations of serum aspartate transferase were observed. Leukoencephalopathy with clinical manifestations occurred in two patients (one had prior cranial irradiation). Pharmacokinetic studies carried out at the 120- and 1080-mg/m2 dose levels revealed no significant difference in the elimination half-life at the two dose levels studied and no significant intrapatient variability between day 1 and day 8 edatrexate administration. Serum edatrexate levels measured using a dihydrofolate reductase inhibition assay correlated with those by high-performance liquid chromatography. Three major and two minor antitumor responses occurred. The maximum tolerated dose was 3750 mg/m2, with grade 3 or 4 leukopenia (one patient), stomatitis (one patient), and leukoencephalopathy (one patient). Because of the occurrence of leukoencephalopathy, further study of high-dose edatrexate with leucovorin rescue is not recommended.     

EWA splatting

We present a framework for high quality splatting based on elliptical Gaussian kernels. To avoid aliasing artifacts, we introduce the concept of a resampling filter, combining a reconstruction kernel with a low-pass filter. Because of the similarity to Heckbert's (1989) EWA (elliptical weighted average) filter for texture mapping, we call our technique EWA splatting. Our framework allows us to derive EWA splat primitives for volume data and for point-sampled surface data. It provides high image quality without aliasing artifacts or excessive blurring for volume data and, additionally, features anisotropic texture filtering for point-sampled surfaces. It also handles nonspherical volume kernels efficiently; hence, it is suitable for regular, rectilinear, and irregular volume datasets. Moreover, our framework introduces a novel approach to compute the footprint function, facilitating efficient perspective projection of arbitrary elliptical kernels at very little additional cost. Finally, we show that EWA volume reconstruction kernels can be reduced to surface reconstruction kernels. This makes our splat primitive universal in rendering surface and volume data.     

Vereinfachte,wirklichkeitsnahe Ermittlung der Durchbiegung von Stahlbetonträgern unter Kriechbeanspruchung

Simplified, realistical Estimation of Deflection of reinforced concrete Beams under service Loads A calculation method, which is based on the assumption of affinity of moment and curvature, for simplified estimation of deflections of reinforced concrete beams under service loads is presented. The influence of creep deformations is considered realistically and enables computational close‐to‐practice calculation of deflections with minimum expense.     

Die Methode der effektiven Spannungen zur einfachen Berechnung der Kriechverformung von Stahlbetonträgern

The method of effective stresses for simple calculation of creep deflections of reinforced concrete girders A method for simple calculations of deflections of reinforced concrete beams is taken on and enhanced. It is shown how the results of computer analysis on the basis of linear‐elastic material behaviour can replace the integration of the curvature distribution by hand to evaluate the deflection. For a systematic evaluation of deflections of reinforced concrete beams with regard to creep effects, parameters of major influence are identified and first evaluations are presented.     

Capacity-achieving ensembles for the binary erasure channel with bounded complexity

We present two sequences of ensembles of nonsystematic irregular repeat-accumulate (IRA) codes which asymptotically (as their block length tends to infinity) achieve capacity on the binary erasure channel (BEC) with bounded complexity per information bit. This is in contrast to all previous constructions of capacity-achieving sequences of ensembles whose complexity grows at least like the log of the inverse of the gap (in rate) to capacity. The new bounded complexity result is achieved by puncturing bits, and allowing in this way a sufficient number of state nodes in the Tanner graph representing the codes. We derive an information-theoretic lower bound on the decoding complexity of randomly punctured codes on graphs. The bound holds for every memoryless binary-input output-symmetric (MBIOS) channel and is refined for the binary erasure channel.