Boosting H2O2‐Guided Chemodynamic Therapy of Cancer by Enhancing Reaction Kinetics through Versatile Biomimetic Fenton Nanocatalysts and the Second Near‐Infrared Light Irradiation

Fenton reaction–based chemodynamic therapy (CDT) has attracted considerable attention for tumor treatment, because the Fenton reaction can degrade endogenous H₂O₂ within the tumor to form reactive oxygen species (ROS) to kill cancer cells. The kinetics of the Fenton reaction has significantly influenced its treatment efficacy. It is crucial to enhance the reaction kinetics at the maximum H₂O₂ concentration to quickly produce vast amounts of ROS to achieve treatment efficacy, which to date, has not been realized. Herein, reported is an efficacious CDT treatment of breast cancer using biomimetic CS‐GOD@CM nanocatalysts, which are rationally designed to significantly boost the Fenton reaction through improvement of H₂O₂ concentration within tumors, and application of the second near‐infrared (NIR‐II) light irradiation at the maximum concentration, which is monitored by photoacoustic imaging. The biomimetic nanocatalysts are composed of ultra‐small Cu_2?xSe (CS) nanoparticles, glucose oxidase (GOD), and tumor cell membrane (CM). The nanocatalysts can be retained in tumor for more than two days to oxidize glucose and produce an approximately 2.6‐fold increase in H₂O₂ to enhance the Fenton reaction under the NIR‐II irradiation. This work demonstrates for the first time the CDT treatment of cancer enhanced by the NIR‐II light.     

Fuzzy neural network-based real-time self-reaction of mobile robot in unknown environments

In this paper, a hybrid intelligent method including fuzzy inference and neural network is presented for real-time self-reaction of a mobile robot in unknown environments. A neural network with fuzzy inference (fuzzy neural network, FNN) presented can effectively improve the learning speed of the neural network. The method can be used to control a mobile robot based on the present motion situations of the robot in real-time; these situations include the distances in different directions between the obstacles and the robot provided by ultrasonic sensors, the target orientation sensed by a simple optical range-finder and the movement direction of the robot. Simulation results showed that the above method can quickly map the fuzzy relationship between the inputs and the output of the control system of the mobile robot.     

Effect of exit and injection rates on phase-dependent transient evolution of gain without inversion

It is shown that in an open Λ-type system with spontaneously generated coherence, the transient evolution rule of the gain of lasing without inversion (LWI) is very sensitive to variation of the relative phase φ between the probe and driving fields; the variety of the atomic exit rateγ_0 and the ratio C of the atomic injection rates also have a considerable effect on the phase-dependent transient evolution rule of LWI gain. We find that whenφ=0, the transient and stationary LWI gain increases with C increasing but decreases with γ_0 increasing; whenφ≠0 , the effect of C andγ_0 on LWI gain is just opposite to that when φ=0 ; in order to get the largest transient and stationary LWI gain, we need selecting suitable values of φ,γ_0 and C.     

All‐in‐One Theranostic Nanoplatform Based on Hollow TaOx for Chelator‐Free Labeling Imaging,Drug Delivery,and Synergistically Enhanced Radiotherapy

Despite extensive use of radiotherapy in cancer treatment, there has been huge demand to improve its efficacy and accuracy in tumor destruction. To this end, nanoparticle‐based radiosensitizers, particularly those with high‐Z elements, have been explored to enhance radiotherapy. Meanwhile, imaging is an essential tool prior to the individual planning of precise radiotherapy. Here, hollow tantalum oxide (H‐TaOx) nanoshells are prepared using a one‐pot template‐free method and then modified with polyethylene glycol (PEG), yielding H‐TaOx‐PEG nanoshells for imaging‐guided synergistically enhanced radiotherapy. H‐TaOx‐PEG nanoshells show strong intrinsic binding with metal ions such as Fe³⁺ and ^99mTc⁴⁺ upon simple mixing, enabling magnetic resonance imaging and single photon emission computed tomography imaging, respectively, which are able to track in vivo distribution of those nanoshells and locate the tumor. With mesoporous shells and large cavities, those H‐TaOx‐PEG nanoshells show efficient loading of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), a hydrophobic chemotherapeutic drug. By means of the radiosensitization effect of Ta to deposit X‐ray energy inside tumors, as well as SN‐38‐induced cell cycle arrest into radiation‐sensitive phases, H‐TaOx‐PEG@SN‐38 can offer remarkable synergistic therapeutic outcome in the combined chemoradiotherapy. Without appreciable systemic toxicity, such hollow‐TaOx nanostructure may therefore find promising applications in multimodal imaging and enhanced cancer radiotherapy.     

基于细菌进化及多属性决策的航迹规划方法研究

为了优化和完善航迹规划,将细菌进化算法和多属性决策理论相结合。对转弯角的编码考虑了飞行器过载限制;生成初始种群时初始角度分散选取,以保证种群多样性防止早熟;通过变异和基因转移,减少种群数目,加快进化速度;采用生存概率、路径长度、转弯角度综合评价航迹,应用多属性决策方法选择最优航迹。仿真结果表明,优化效率显著提高,规划的航迹有效地规避了威胁。     

FPGA器件的开发平台与MATLAB接口仿真

针对FPGA设计软件Quartusll的仿真功能在可视性方面的局限性给程序早期仿真来的不便,本文提出一种将FPGA开发平台与MATLAB接口仿真的方法。该方法利用Matlab软件的计算功能与可视化仿真功能,大大地方便设计人员对设计项目进行早期修正。[编者按]     

IEEE 802.16d标准中无缝切换的探讨

IEEE 802.16d（即802.16-2004）标准是2004年6月正式出台的固定宽带无线接入空中接口标准,其最初目标是提供固定场所的“最后一公里”无线接入.通过理论分析证明了802.16d标准也可以在移动环境下实现无缝的线路切换,并设计出相应的切换协议.     

Reduced Graphene Oxides Modified Bi2Te3 Nanosheets for Rapid Photo-Thermoelectric Catalytic Therapy of Bacteria-Infected Wounds

Temperature variation-induced thermoelectric catalytic efficiency of thermoelectric material is simultaneously restricted by its electrical conductivity, Seebeck coefficient, and thermal conductivity. Herein, Bi₂Te₃ nanosheets are in situ grown on reduced graphene oxides (rGO) to generate an efficient photo-thermoelectric catalyst (rGO-Bi₂Te₃). This system exhibits phonon scattering effect and extra carrier transport channels induced by the formed heterointerface between rGO and Bi₂Te₃, which improves the power factor value and reduces thermal conductivity, thus enhancing the thermoelectric performance of 2.13 times than single Bi₂Te₃. The photo-thermoelectric catalysis of rGO-Bi₂Te₃ significantly improves the reactive oxygen species yields, resulting from the effective electron–hole separation caused by the unique thermoelectric field and heterointerfaces of rGO-Bi₂Te₃. Correspondingly, the electrospinning membranes containing rGO-Bi₂Te₃ nanosheets exhibit high antibacterial efficiency in vivo (99.35 ± 0.29%), accelerated tissue repair ability, and excellent biosafety. This study provides an insight into heterointerface design in photo-thermoelectric catalysis.     

Impact of wide-band I/Q modulation errors in SAR imaging analysis and compensation method resaerch

Direct quadrature modulation technology is suitable for wide-band radar signal generation. However, this method has rigorous requirements on amplitude and phase balance of the orthogonal input signals. If the requirements are not satisfied, there would be modulation errors such as image frequency and oscillator leakage that cannot be filtered. The modulation errors will therefore raise the noise floor of the range profile and reduce the dynamic range of the Synthetic Aperture Radar (SAR) image as a whole. In this paper, the wide-band In-phase/Quadrature-phase (I/Q) modulation errors are modeling analyzed, and the influence of wide-band I/Q modulation errors on SAR imaging is discussed. Furthermore, a compensation method of modulation errors is proposed, and the circuit implementation of the radar signal generation and pre-distortion is presented. The experimental results illustrate that the curves of the I/Q amplitude and phase imbalance errors are successfully extracted and the rejection of image frequency improved significantly, thus meets the requirements of the SAR imaging.     

On the design of feed-forward ΣΔ interface for MEMS based accelerometers

High order ???? interface is popular for high resolution micro-electro-mechanical systems. Previous researches are mainly about the coefficients of the multiple feedback electromechanical ???? modulators. In the work presented here, a systematic design method for the feed forward ???? interfaces is proposed. Simulations show that utilizing the proposed method, feed forward and the optimized multiple feedback electromechanical sigma-delta modulators have almost the same SQNRs when a compensator pole is added to the feed forward structure. However, the feed forward structures have many advantages, so the proposed method is a promising alternative method for the multiple feedback structure.