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31.
Nie Xin-min Gui Rong Zhao Hong-shan Ma Da-long Li Deng-qing Yuan Hong Huang Zu-fa 《中南工业大学学报(英文版)》2005,12(1):310-312
Objective Tacrolimus is an immunosuppressive drug with narrow therapeutic range and wide interindividual variation in its pharmacokinetics.
Tacrolimus is a substrate of cytochrome P450(CYP)3A5. The aim of this study was to evaluate whether the A6986G polymorphism
is associated with tacrolimus concentration /dose ratio. Methods Fifty-two Chinese renal transplant patients were enrolled in this study. Their body weight, dosage and concentration of tacrolimus
were observed. CYP3A5 genotype was determined by polymerase chain reaction followed by restriction fragment length polymorphism
analysis. Results A significant association was found between tacrolimus levels per dose/kg/d and CYP3A5 gene A6986G polymorphism (P<0.001). The CYP3A5 * 3 * 3 patients have a significantly higher tacrolimus level/dose than CYP3A5 * 1 * 1 and CYP3A5 * 1
* 3. Conclusions CYP3A5 gene A6986G polymorphism is associated with tacrolimus pharmacokinetics and dose requirements. Pharmacogenetic methods
could be employed prospectively to help the dose selection and to individualize immunosuppressive therapy according to the
result.
Foundation item: Project (03GZ3072) supported by the Science and Technology Department of Hunan Province; project (2004035206) supported by
the China Postdoctoral Foundation and project (30300383) supported by the National Natural Sciences Foundation of China 相似文献
32.
33.
A novel milk-like Cu-thiourea colloid has been synthesized. Nanocrystalline quaternary copper sulfide Cu2FeSnS4 was obtained through the Cu-thiourea colloidal precursor cooperative conversion route at low temperature. The samples were characterized by means of X-ray powder diffraction, transmission electron microscopy, scanning electron microscopy, inductively coupled plasma atomic emission spectroscopy, and X-ray energy dispersive spectroscopy techniques. The reaction details and features were described and discussed. 相似文献
34.
The catalysts of CeO2 and the mixture of CeO2 and CuO were prepared, and the activities of these catalysts for completely oxidizing benzene were studied.The results show that the optimal proportion of CeO2/CuO is 6: 4.The highest temperature at which benzene was completely oxidized on these catalysts at different airspeed was measured.Compared these catalysts with the noble metal used, our catalysts had superiority in the resources and the industrial cost besides good activities. 相似文献
35.
Yue Rong Yingbo Hua Swami A. Swindlehurst A.L. 《Signal Processing, IEEE Transactions on》2008,56(2):686-701
A space-time optimal power schedule for multiple distributed multiple-input multiple-output (MIMO) links without the knowledge of the instantaneous channel state information (CSI) at the transmitting nodes is proposed. A readily computable expression for the ergodic sum capacity of the MIMO links is derived. Based on this expression, which is a non-convex function of power allocation vectors, a projected gradient algorithm is developed to optimize the power allocation. For a symmetric set of MIMO links with independent identically distributed channels, it is observed that the space-time optimal power schedule reduces to a uniform isotropic power schedule when nominal interference is low, or to an orthogonal isotropic power schedule when nominal interference is high. Furthermore, the transition region between the latter two schedules is seen to be very sharp in terms of nominal interference-to-noise ratio (INR). For MIMO links with correlated channels, the corresponding space-time optimal power schedule is developed based on the knowledge of the channel correlation matrices. It is shown that the channel correlation has a great impact on the ergodic capacity and the optimality of different power scheduling approaches. 相似文献
36.
37.
介绍了在直流电弧放电法制备富勒烯过程中,从阴电极表面收集到大量的碳纳米管及巴基葱,产生率达到50%,并用电子显微镜对其进行了观察和初步研究。 相似文献
38.
This paper presents the dynamic performance analysis and closed-loop design of a new power supply system for a high-current magnet load. This new system introduces a series switch-mode ripple regulator (SMRR) into a phase-controlled rectifier to improve system dynamic response and to reduce the harmonic content in the magnet current. In this paper, the new system control configuration is explained. The small signal dynamic model is established. The function of the SMRR as a speed-up feed-forward path during dynamic transients is assessed. The criteria of the closed-loop regulator design are identified. The theoretical analyses are accompanied by computer simulation and experimental results. The systematical design procedure is outlined by an example which offers better performance than ever reported on high-current magnet power supplies in terms of fast dynamic response (closed-loop bandwidth several kHz) and low harmonic content (less than 10 ppm) in the magnet current 相似文献
39.
本文对峒室爆破断面布药计算机辅助设计参数驱动方法进行了探讨围绕断面布药主要参数的变化,提出一种基于参数驱动的计算机辅助设计方法,利用windows操作系统下的动态数据交换特性,对断面布药进行布药参数优化,实现了交互调整布药,形成一套断面布的计算机软件,为工程爆破设计实现计算机提供了一种可行的方法。 相似文献
40.
热释电红外摄像机斩波调制电路的设计 总被引:1,自引:0,他引:1
本文提出了热释电红外摄像机斩波调制的电路模型,并对此电路模型进行了具体的电路设计和分析。 相似文献