The day of the week when you were born in 700 ms: Calendar computation in an autistic savant.

Some individuals are able to determine the weekday of a given date in a few seconds (finding for instance that June 12, 1900, was a Tuesday). This ability has fascinated scientists for many years because it is predominantly observed in people with limited intelligence and may appear very early in life. Exceptional visual memory, exceptional concentration abilities, or privileged access to lower levels of information not normally available through introspection have been advanced to explain such phenomena. In the present article, the authors show that a simple cognitive model can explain all aspects of the performance of Donny, a young autistic savant who is possibly the fastest and most accurate calendar prodigy ever described. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Impact of Reaction Conditions on MnO2 Genesis during Permanganate Oxidation

To enhance the understanding of the behavior and effects of the precipitation of MnO2 particles in the subsurface generated during in situ chemical oxidation (ISCO) using permanganate, laboratory batch experiments were completed to examine the influence that varied reaction matrix conditions have on the generation and properties of manganese oxides. The conditions examined include organic material type and concentration, permanganate concentration, pH, and the presence of calcium (as a representative divalent cation) in solution. Experimental studies included: (1) spectrophotometric examination of permanganate depletion and manganese oxides generation over time during reactions with trichloroethene; (2) scanning electron microscopy analyses of manganese particle morphology; (3) particle size distribution (filtration) characterization studies; and (4) optical particle sizing and numeration studies. Bench-scale, batch experiments were conducted to focus on fundamental chemical properties affecting particle development under varied potential environmental conditions. The amount of manganese oxides particles that develop, grow, and potentially settle as a result of permanganate ISCO of organic contaminants is a function of the particle size and concentration, the time allowed for particle development, and the impact of matrix conditions on the ability of particles to agglomerate.     

The Precedence Effect in Three Species of Birds (Melopsittacus undulatus, Serinus canaria, and Taeniopygia guttata).

The perceived locations of paired auditory images, simulating direct sounds and their echoes, have been recently studied in budgerigars (Melopsittacus undulatus; M. L. Dent & R. J. Dooling, 2003a, 2003b). In this article, the authors extend those experiments to include measurements of the precedence effect using a discrimination paradigm in two additional bird species: canaries (Serinus canaria) and zebra finches (Taeniopygia guttata). Although time courses of summing localization, localization dominance, and echo thresholds were similar across all species, budgerigars had slightly higher overall levels of discrimination. The results from these experiments add further support that the precedence effect in birds is similar to that found in other animals and that the ability to suppress echoes that might degrade localization and auditory object perception may be a general property of the vertebrate auditory system. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Dual command travel times and miniload system throughput with turnover-based storage

We analyze travel times for automated storage/retrieval systems. In particular, we apply our travel time model to turnover-based storage systems and determine the mean and variance of dual command travel times. We present detailed numerical results for selected rack shape factors and ABC inventory profiles. We then investigate the effect of alternative rack configurations on travel time performance measures. We also show how to determine the throughput of miniload systems with turnover-based storage and exponentially distributed pick times.     

Capacity Efficiency and Restorability of Path Protection and Rerouting in WDM Networks Subject to Dual Failures

Resilient optical networks are predominately designed to protect against single failures of fiber links. But in larger networks, operators also see dual failures. As the capacity was planned for single failures, disconnections can occur by dual failures even if enough topological connectivity is provided. In our approach the design of the network minimizes the average loss caused by dual failures, while single failures are still fully survived. High dual failure restorability is the primary aim, capacity is optimized in a second step. For WDM networks with full wavelength conversion, we formulate mixed integer linear programming models for dedicated path protection, shared (backup) path protection, and path rerouting with and without stub-release. For larger problem instances in path rerouting, we propose two heuristics. Computational results indicate that the connectivity is of much more importance for high restorability values than the overall protection capacity. Shared protection has similar restorability levels as dedicated protection while the capacity is comparable to rerouting. Rerouting surpasses the protection mechanisms in restorability and comes close to 100% dual failure survivability. Compared to single failure planning, both shared path protection and rerouting need significantly more capacity in dual failure planning.     

Child Death From Pediatric Illness: Conceptualizing Intervention From a Family/Systems and Public Health Perspective.

Despite the universal and understandable distress associated with the death of a child from pediatric illness, do psychologists help surviving families in ways that match their need for assistance? Many families do not seek psychological help and cope adaptively with their loss. Indications for psychotherapy with bereaved families are based largely on experience with families who engage in treatment and who have greater distress. Other families may not receive sufficient services but are at risk for ongoing difficulties and unlikely to engage in treatment. Suggestions for intervention are made, with attention to the fit of therapeutic approaches with family needs. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

An aldose reductase inhibitor and aminoguanidine prevent vascular endothelial growth factor expression in rats with long-term galactosemia

OBJECTIVE: To study the effects of an aldose reductase inhibitor (ARI-509, Wyeth-Ayerst, Princeton, NJ) and aminoguanidine (AMG), agents that have been reported to prevent or delay diabetic retinopathy, on retinal vascular abnormalities and the immunocytochemical expression in the retina of vascular endothelial growth factor (VEGF) in rats maintained for up to 2 years on a 50% galactose diet. METHODS: Albino rats were placed on a control diet, a diet containing 50% galactose, or the 50% galactose diet containing either ARI-509 or AMG. Treatment with ARI-509 or AMG was initiated at the beginning of the experiment or after 12 months of galactose feeding. After 22 to 24 months, the rats were killed and the retinal vasculature from half of one eye was isolated by trypsin-elastase digestion for semiquantitative evaluation of retinal vascular lesions. The other half of the retina was prepared for immunocytochemistry and stained for the presence of VEGF, factor VIII, vimentin, and glial fibrillary acidic protein. Red blood cells, sciatic nerves, and a portion of the retina from the second eye were assayed for glucose, galactose, fructose, sorbitol, galactitol, and myo-inositol. Red blood cells were also assayed for galactosylated hemoglobin. RESULTS: Galactose-fed animals developed a vascular retinopathy characterized by severe cellular loss in the retinal capillaries and intensification of periodic acid-Schiff staining of the vascular basement membranes. Some animals also displayed dilation and hypercellularity of vessels in the posterior retina. These changes were substantially reduced in animals receiving ARI-509 from the beginning of the galactose diet, but were unaffected in all of the other treatment groups. None of the rats receiving ARI-509 or AMG treatment, whether initiated from the onset or after 12 months of galactosemia, demonstrated VEGF immunoreactivity. With the exception of the animals receiving ARI-509 from the beginning of the experiment, all of the galactose-fed animals developed dense cataracts within 6 weeks of the beginning of the galactose diet. Galactitol levels in animals receiving ARI-509 were 86% to 93% lower in red blood cells, retina, and sciatic nerve than those in the other galactose-fed groups. CONCLUSIONS: Although ARI-509 and AMG have different abilities to delay or prevent the diabetic-like retinopathy in galactosemic rats, even when substantial retinal microvascular acellularity occurs, both drugs prevent the immunocytochemical expression of VEGF. These results suggest that factors other than hypoxia may be responsible for VEGF expression in the retina, and that aldose reductase inhibitors and AMG have potential roles in preventing such expression and, thus, perhaps preventing retinal neovascularization.