A change management framework for macroergonomic field research

With the proliferation of macroergonomic field research, it is time to carefully examine how such research should be managed and implemented. We argue that the importance of attending to high-quality implementation of field research is equal to that of methodological rigor. One way to systematically manage the implementation process is to adopt a change management framework, wherein the research project is conceptualized as an instance of organization-level change. Consequently, principles for successful organization-level change from the literature on change management can be used to guide successful field research implementation. This paper briefly reviews that literature, deriving 30 principles of successful change management, covering topics such as political awareness, assembling the change team, generating buy-in, and management support. For each principle, corresponding suggestions for macroergonomic field research practice are presented. We urge other researchers to further develop and adopt frameworks that guide the implementation of field research.     

Correlation of slurry reactor Fischer-Tropsch yield data

First stage slurry reactor Fischer-Tropsch (FT) yield data from Mobil's two-step pilot plant operations for the DOE have been correlated using a modified Schulz-Flory approach but allowing for changes in the probability of chain growth, , at key product molecular weights. Triple values of are invoked to explain (1) the high methane yield and (2) the very broad molecular weight distribution of the wax fraction, as compared to (3) moderate values of ₂ of between 0.79 and 0.85 for the C₂–C₂₀ hydrocarbons. Over this range, wax yields from 10 to 76 wt% are accommodated, at values of ₃ from 0.90 to 0.98. The second break in the yield-molecular weight curve occurs at the carbon number where most of the component remains in the reactor as liquid rather than leaving as vapor product. It is assumed that this is a function of vapor-liquid equilibrium. The correlation has proven useful in developing a computer model of the FT synthesis loop which is part of a baseline design and economic study for DOE/PETC.     

A Hybrid Strategy-Based Ultra-Narrow Stretchable Microelectrodes with Cell-Level Resolution

Stretchable ultra-narrow (e.g., 10 µm in width) microelectrodes are crucial for the electrophysiological monitoring of single cells providing the fundamental understanding to the working mechanism of neuro network or other electrically functional cells. Current fabrication strategies either focus on the preparation of normal stretchable electrodes with hundreds of micrometers or millimeters in width by using inorganic conductive materials or develop conductive organic polymer gel for ultra-narrow electrodes which suffer from low stretchability and instability for long-term implantation, therefore, it is still highly desirable to explore bio-interfacial ultra-narrow stretchable inorganic electrodes. Herein, a hybrid strategy is reported to prepare ultra-narrow multi-channel stretchable microelectrodes without using photolithography or laser-assisting etching. A 10 µm × 10 µm monitoring window is fabricated with enhanced interfacial impedance by the special rough surface. The stretchability achieves to 120% for this 10 µm-width stretchable electrode. Supported by these superior properties, it is demonstrated that the stretchable microelectrodes can detect electrophysiological signals of single cells in vitro and collect electrophysiological signals more precisely in vivo. The reported strategy will open up the accessible preparation of the fine-size stretchable microelectrode. It will significantly improve the resolution of monitoring and stimulation of inorganic stretchable electrodes.     

Diagnostic performance of edited 2HG MR spectroscopy of central glioma in the clinical environment

Magnetic Resonance Materials in Physics, Biology and Medicine - Oncometabolite D-2-hydroxyglutarate (2HG) is pooled in isocitrate dehydrogenase (IDH)-mutant glioma cells. Detecting 2HG by MR...     

Targeted Nanoparticle Thermometry: A Method to Measure Local Temperature at the Nanoscale Point Where Water Vapor Nucleation Occurs

An optical nanothermometer technique based on laser trapping, moving and targeted attaching an erbium oxide nanoparticle cluster is developed to measure the local temperature. The authors apply this new nanoscale temperature measuring technique (limited by the size of the nanoparticles) to measure the temperature of vapor nucleation in water. Vapor nucleation is observed after superheating water above the boiling point for degassed and nondegassed water. The average nucleation temperature for water without gas is 560 K but this temperature is lowered by 100 K when gas is introduced into the water. The authors are able to measure the temperature inside the bubble during bubble formation and find that the temperature inside the bubble spikes to over 1000 K because the heat source (optically‐heated nanorods) is no longer connected to liquid water and heat dissipation is greatly reduced.     

Neural Machine Translation by Fusing Key Information of Text

When the Transformer proposed by Google in 2017, it was first used for machine translation tasks and achieved the state of the art at that time. Although the current neural machine translation model can generate high quality translation results, there are still mistranslations and omissions in the translation of key information of long sentences. On the other hand, the most important part in traditional translation tasks is the translation of key information. In the translation results, as long as the key information is translated accurately and completely, even if other parts of the results are translated incorrect, the final translation results’ quality can still be guaranteed. In order to solve the problem of mistranslation and missed translation effectively, and improve the accuracy and completeness of long sentence translation in machine translation, this paper proposes a key information fused neural machine translation model based on Transformer. The model proposed in this paper extracts the keywords of the source language text separately as the input of the encoder. After the same encoding as the source language text, it is fused with the output of the source language text encoded by the encoder, then the key information is processed and input into the decoder. With incorporating keyword information from the source language sentence, the model’s performance in the task of translating long sentences is very reliable. In order to verify the effectiveness of the method of fusion of key information proposed in this paper, a series of experiments were carried out on the verification set. The experimental results show that the Bilingual Evaluation Understudy (BLEU) score of the model proposed in this paper on the Workshop on Machine Translation (WMT) 2017 test dataset is higher than the BLEU score of Transformer proposed by Google on the WMT2017 test dataset. The experimental results show the advantages of the model proposed in this paper.     

Graph-based quadratic optimization: A fast evolutionary approach

Quadratic optimization lies at the very heart of many structural pattern recognition and computer vision problems, such as graph matching, object recognition, image segmentation, etc., and it is therefore of crucial importance to devise algorithmic solutions that are both efficient and effective. As it turns out, a large class of quadratic optimization problems can be formulated in terms of so-called “standard quadratic programs” (StQPs), which ask for finding the extrema of a quadratic polynomial over the standard simplex. Computationally, the standard approach for attacking this class of problems is to use replicator dynamics, a well-known family of algorithms from evolutionary game theory inspired by Darwinian selection processes. Despite their effectiveness in finding good solutions in a variety of applications, however, replicator dynamics suffer from being computationally expensive, as they require a number of operations per step which grows quadratically with the dimensionality of the problem being solved. In order to avoid this drawback, in this paper we propose a new population game dynamics (InImDyn) which is motivated by the analogy with infection and immunization processes within a population of “players.” We prove that the evolution of our dynamics is governed by a quadratic Lyapunov function, representing the average population payoff, which strictly increases along non-constant trajectories and that local solutions of StQPs are asymptotically stable (i.e., attractive) points. Each step of InImDyn is shown to have a linear time/space complexity, thereby allowing us to use it as a more efficient alternative to standard approaches for solving StQPs and related optimization problems. Indeed, we demonstrate experimentally that InImDyn is orders of magnitude faster than, and as accurate as, replicator dynamics on various applications ranging from tree matching to image registration, matching and segmentation.     

RANGE–Robust autonomous navigation in GPS‐denied environments

This paper addresses the problem of autonomous navigation of a micro air vehicle (MAV) in GPS‐denied environments. We present experimental validation and analysis for our system that enables a quadrotor helicopter, equipped with a laser range finder sensor, to autonomously explore and map unstructured and unknown environments. The key challenge for enabling GPS‐denied flight of a MAV is that the system must be able to estimate its position and velocity by sensing unknown environmental structure with sufficient accuracy and low enough latency to stably control the vehicle. Our solution overcomes this challenge in the face of MAV payload limitations imposed on sensing, computational, and communication resources. We first analyze the requirements to achieve fully autonomous quadrotor helicopter flight in GPS‐denied areas, highlighting the differences between ground and air robots that make it difficult to use algorithms developed for ground robots. We report on experiments that validate our solutions to key challenges, namely a multilevel sensing and control hierarchy that incorporates a high‐speed laser scan‐matching algorithm, data fusion filter, high‐level simultaneous localization and mapping, and a goal‐directed exploration module. These experiments illustrate the quadrotor helicopter's ability to accurately and autonomously navigate in a number of large‐scale unknown environments, both indoors and in the urban canyon. The system was further validated in the field by our winning entry in the 2009 International Aerial Robotics Competition, which required the quadrotor to autonomously enter a hazardous unknown environment through a window, explore the indoor structure without GPS, and search for a visual target. © 2011 Wiley Periodicals, Inc.     

Infinite factorization of multiple non-parametric views

Combined analysis of multiple data sources has increasing application interest, in particular for distinguishing shared and source-specific aspects. We extend this rationale to the generative and non-parametric clustering setting by introducing a novel non-parametric hierarchical mixture model. The lower level of the model describes each source with a flexible non-parametric mixture, and the top level combines these to describe commonalities of the sources. The lower-level clusters arise from hierarchical Dirichlet Processes, inducing an infinite-dimensional contingency table between the sources. The commonalities between the sources are modeled by an infinite component model of the contingency table, interpretable as non-negative factorization of infinite matrices, or as a prior for infinite contingency tables. With Gaussian mixture components plugged in for continuous measurements, the model is applied to two views of genes, mRNA expression and abundance of the produced proteins, to expose groups of genes that are co-regulated in either or both of the views. We discover complex relationships between the marginals (that are multimodal in both marginals) that would remain undetected by simpler models. Cluster analysis of co-expression is a standard method of screening for co-regulation, and the two-view analysis extends the approach to distinguishing between pre- and post-translational regulation.