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Shinya Takigawa Andy Chen Akinobu Nishimura Shengzhi Liu Bai-Yan Li Akihiro Sudo Hiroki Yokota Kazunori Hamamura 《International journal of molecular sciences》2016,17(5)
Integrated stress responses (ISR) may lead to cell death and tissue degeneration via eukaryotic translation initiation factor 2 α (eIF2α)-mediated signaling. Alleviating ISR by modulating eIF2α phosphorylation can reduce the symptoms associated with various diseases. Guanabenz is known to elevate the phosphorylation level of eIF2α and reduce pro-inflammatory responses. However, the mechanism of its action is not well understood. In this study, we investigated the signaling pathway through which guanabenz induces anti-inflammatory effects in immune cells, in particular macrophages. Genome-wide mRNA profiling followed by principal component analysis predicted that colony stimulating factor 2 (Csf2, or GM-CSF as granulocyte macrophage colony stimulating factor) is involved in the responses to guanabenz. A partial silencing of Csf2 or eIF2α by RNA interference revealed that Interleukin-6 (IL6), Csf2, and Cyclooxygenase-2 (Cox2) are downregulated by guanabenz-driven phosphorylation of eIF2α. Although expression of IL1β and Tumor Necrosis Factor-α (TNFα) was suppressed by guanabenz, their downregulation was not directly mediated by eIF2α signaling. Collectively, the result herein indicates that anti-inflammatory effects by guanabenz are mediated by not only eIF2α-dependent but also eIF2α-independent signaling. 相似文献
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A Macro‐Damaged Viscoelastoplastic Model for Thermomechanical and Rate‐Dependent Behavior of Glassy Polymers 下载免费PDF全文
The primary objective of this paper is to develop a macro‐damaged viscoelastoplastic constitutive model to describe large deformation mechanical behavior for glassy polymers at various kinds of experimental conditions. First of all, quasi‐static and dynamic tension and compression tests were carried out to obtain stress–strain responses over wide range of rates and temperatures for two glassy polymeric materials, polymethylmethacrylate and polycarbonate. Then a phenomenological macroscopic damage model, covering effects of strain rates, temperatures, and effective strain, is incorporated into the constitutive model in the previous work. Furthermore, two distinct criteria are applied to predict the damage evolution affected by strain rate and temperature at elastic phase and plastic phase, respectively. The validations of the novel developed damaged model are made by the better matches with the testing data compared with the original undamaged model, and excellent agreements with the experimental result in all cases.
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吸附式制冷是一种能利用低品位热能的节能环保的制冷方式。在空调工况下,硅胶-水回质回热系统应用最多。为了解在特定工况下选择何种循环能提升系统性能,应用热力学第一与第二定律评价指标分析了基本循环、回质循环、回质回热循环的COP、(火用)效率、循环熵产。分析表明,回质循环存在推荐最高热源温度和最优热源温度,回质回热循环存在推荐最低热源温度和最优热源温度。例如对于典型夏季空调工况热源温度90℃、蒸发温度10℃、冷凝温度40℃,回质循环的推荐最高热源温度为93℃,高于实际热源温度90℃,选用回质循环更合适而非回质回热循环。最后,对制冷机组的分析表明给出的方法和推荐工作温度区间能针对实际系统给出方案优选和系统控制的指导性建议。 相似文献
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Xiaoyan Song Shengzhi Zhou Yuanfeng Wang Weimin Kang Bowen Cheng 《Journal of Polymer Research》2012,19(1):9812-8
A novel polypropylene/Polyhedral oligomeric silsesquioxanes (PP/POSS) composite unwoven fabric with permanent electret was
prepared through melt-blown process with corona charging. Field-emission scanning electron microscope (FESEM) and wide-angle
X-ray diffraction (WAXRD) were employed to investigate the morphology of the composite fibers and the distribution of POSS
nanoparticles on the surface of the fibers, respectively. POSS acted as nucleating agent and accelerated the crystallization
process during nonisothermal cooling. The utmost stable charge density of PP/POSS melt-blown unwoven fabric was improved by
78.4% compared with the neat PP unwoven fabric. The maximum value of collection efficiency measured by monodisperse polystyrene
aerosol (PSL) (particle size: 0.3 μm) collection could reach 97.36% for PP/POSS composite melt-blown unwoven fabric, which
improved by 9% compared with neat PP melt-blown unwoven fabric. Moreover, both stress and elongation at break of the PP/POSS
melt-blown unwoven fabrics were improved compared with PP unwoven fabric. 相似文献
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基于狄舍尔穿孔机轧辊开度的分析,讨论了调整参数的计算方法,提出将送进角作为改善毛管横向壁厚均匀性的手段。 相似文献
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在中央提出加快培育煤炭大集团决策的推动下,各主要产煤省区纷纷重组、整合大型煤炭企业。大型煤企组建后,将面临多种复杂的问题,最突出的当数主业与辅业、一元主导与多元发展的问题,而影响大型煤企长远发展大计的当聚焦在其产业链的设计、延展和闭合上。初步分析和探讨了重组后的煤炭企业应当构建什么样的产业链以及产业链整合的相应对策。 相似文献
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