The influence of drug solubility and particle size on the pellet formulation in a rotoprocessor

Pellets containing drugs of different properties were prepared in a Rotoprocessor in order to study changes in the formulation process and resulting pellet characteristics. Diltiazem hydrochloride, diclofenac sodium, and theophylline were chosen as model drugs. Pellet size distribution, sphericity, density, hardness, friability, and repose angle were determined using standard methods. The amount of water as a wetting agent necessary for successful pellet formulation was observed for each sample and changed depending on drug solubility, concentration, and particle size. The pelletization of freely soluble diltiazem hydrochloride required 24.8-23.1% of the wetting agent and its amount decreased as the drug concentration increased. The demand for water in the formulation of theophylline pellets was 31.0-34.4% and it increased with increasing drug concentration. The pellet samples containing both drugs were easy to prepare. However, the cohesion of micronized diclofenac sodium particles negatively influenced both the pellet size distribution and the formulation process itself. When the drug concentration exceeded 40%, it was not possible to produce pellets of an appropriate size and the process was not reproducible.     

Inverse characterization of NAPL source zones

This work presents a possible tool for inverse characterization of NAPL (nonaqueous phase liquid) source zones in terms of contaminant mass flux. A hybrid solution technique was applied that considers contaminant transport through a vertical flux plane. The hybrid solution technique takes advantage of the robust solution capabilities of simulated annealing (SA) and the uncertainty estimation capabilities of minimum relative entropy (MRE). The coupled technique (SA-MRE) provides probability density functions and confidence intervals that would not be available from an independent SA algorithm, and they are obtained more efficiently than if provided by an independent MRE algorithm. The SA-MRE method was used to characterize a NAPL source zone that was emplaced in a three-dimensional aquifer model. When dissolution experiments were complete, the aquifer model was excavated, and the distribution of NAPL zones was recorded using digital images of excavation grids. The excavation images were compiled into a three-dimensional representation of the source zone for comparison with and validation of modeling results.     

Resolving the Micropayment Problem

Cryptography-based alternatives are the most appropriate long-term solution to the micropayment problem, especially compared to the business solution of restructuring transaction fees. We acknowledge that the business solution is easier to deploy in the short term. Cryptography-based solutions face tremendous deployment challenges: they need more market testing, they significantly change payment-ecosystem processes, their legal implications are unclear, and they require new kinds of devices and processes for merchants. Nonetheless, the long-term payoff of investing in such sound solutions are be tremendous     

问答

Q:在刚刚过去的2006财年,NetApp实现了28亿美元的销售额,同比增长36%,对存储领域的领头羊EMC保持了巨大压力。请问公司快速成长的秘诀是什么? A:关于我们为什么能取得近30亿美元的销售收入并成为这一个市场的领先者,大体上可以归结为三点,第一是因为我们正处于这个市场最黄金的     

Scale-up and endpoint issues of pharmaceutical wet granulation in a V-type low shear granulator

A 3² factorial experiment is conducted in a 57 liter low shear granulator to evaluate the influence of changes in binder strength and agitator speed on the response variables of granule size, granule morphology, granule density and torque input. Results are compared to previous work in a 2 liter granulator and scale-up issues between the two granulators are addressed.     

Extension of belief functions to infinite-valued events

We generalise belief functions to many-valued events which are represented by elements of Lindenbaum algebra of infinite-valued ?ukasiewicz propositional logic. Our approach is based on mass assignments used in the Dempster–Shafer theory of evidence. A generalised belief function is totally monotone and it has Choquet integral representation with respect to a unique belief measure on Boolean events.     

Explainable image classification with evidence counterfactual

Pattern Analysis and Applications - The complexity of state-of-the-art modeling techniques for image classification impedes the ability to explain model predictions in an interpretable way. A...     

Advancing building engineering through structural and topology optimization

Structural and Multidisciplinary Optimization - Traditional building design is often done in a (pseudo-) sequential manner: the architect defines the form, the structural engineer defines the...     

A study of through-thickness texture gradients in rolled sheets

A method to simulate shear effects and through-thickness texture gradients in rolled sheet materials is introduced. The strain history during a rolling pass is idealized by superimposing a sine-shaped evolution of the ₁₃ shear component to a plane-strain state. These generic strain histories are enforced in a visco-plastic self-consistent (VPSC) polycrystal deformation model to simulate texture evolution as a function of through-thickness position. The VPSC scheme is deemed superior to a full constraints (FC) or relaxed constraints (RC) approach, because it allows one to fully prescribe diagonal and shear-strain-rate components while still accounting for grain-shape effects. The idealized strain states are validated by comparison with deformation histories obtained through finite-element method (FEM) calculations. The through-thickness texture gradients are accounted for by introducing a relative variation of the sine-shaped ₁₃ shear with respect to the plane-strain component. The simulation results are validated, in turn, by comparison with typical examples of through-thickness texture gradients observed experimentally in rolled plates and in sheets of fcc and bcc materials.