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排序方式: 共有2155条查询结果,搜索用时 15 毫秒
91.
92.
LP Ormerod A Charlett C Gilham JH Darbyshire JM Watson 《Canadian Metallurgical Quarterly》1998,53(3):176-181
Refractory hypotension with end-organ hypoperfusion is an ominous feature of inflammatory shock. In the past fifteen years, nitric oxide (a diffusible, short-lived product of arginine metabolism) has been found to be an important regulatory molecule in several areas of metabolism, including vascular tone control. Vascular endothelial cells constitutively produce low levels of nitric oxide that regulate blood pressure by mediating adjacent smooth-muscle relaxation. In an inflammatory shock state, cytokines, like interleukin-1 and tumor necrosis factor-alpha, induce a separate, high-output form of the enzyme that synthesizes nitric oxide in both endothelial and smooth-muscle cells. The ensuing high rates of nitric oxide formation result in extensive smooth-muscle relaxation, pressor refractory vasodilation, and--ultimately--shock. The concept of the pathogenesis of inflammatory shock explains many limitations of current therapies and may foster the development of new interventions to mitigate the effects of nitric oxide overproduction in this syndrome. 相似文献
93.
Reduction of mitochondrial membrane potential (Psim) and release of cytochrome c from mitochondria appear to be key events during apoptosis. Apoptosis was induced in IC.DP premast cells by the withdrawal of interleukin-3 (IL-3). Psim decreased by 12 hours and cytochrome c was detected in the cytosol at 18 hours. Despite these changes in the mitochondria after 18 hours of IL-3 deprivation, clonogenicity was unaffected when IL-3 was replenished at 18 hours. Activation of v-Abl tyrosine kinase (v-Abl TK) in IC.DP cells before IL-3 depletion led to increased levels of Bcl-XL, prevented reduction of Psim and the release of mitochondrial cytochrome c, and suppressed apoptosis. Activation of v-Abl TK 18 hours after withdrawal of IL-3 when =10% of the cells had died restored Psim in the remaining cells. More than 40% of cells thus rescued by v-Abl TK between 18 and 42 hours could subsequently form colonies in the presence of IL-3. These data suggest that reduction in Psim precedes loss of mitochondrial cytochrome c in IC.DP cells; that v-Abl TK activation, probably via upregulation of Bcl-XL, prevents loss of Psim and blocks the release of cytochrome c from mitochondria; and that neither of these mitochondrial events is sufficient for commitment to apoptosis. 相似文献
94.
NR Powe RI Griffiths AJ Watson GF Anderson G de Lissovoy JW Greer RJ Herbert RA Milam PK Whelton 《Canadian Metallurgical Quarterly》1994,4(7):1455-1465
To examine the effects of recombinant human erythropoietin (rHuEPO) on hospital utilization, hospital costs, and Medicare reimbursements for hospital care, a longitudinal, matched cohort study was conducted using Medicare claims data of 23,806 Medicare-eligible, dialysis patients who received rHuEPO, did not have a transplant, and were alive for 18 mo or longer and 22,720 controls matched on age, sex, race, cause of ESRD, and dialysis modality. The relative odds (rHuEPO versus control) of admission for all causes and for specific causes over 9 mo, adjusted for admission in the prior 9 mo and the per patient change in total admissions, inpatient days, hospital costs, and Medicare hospital payments between the prior 9-mo period and the subsequent 9-mo period was examined. The adjusted relative odds (95% confidence interval) of admission (rHuEPO versus control) was: higher and statistically significant for all causes, 1.08 (1.03 to 1.14); seizure, 1.52 (1.28 to 1.75); vascular access revision, 1.11 (1.06 to 1.17), and heart failure, 1.17 (1.09 to 1.26); higher but not statistically significant for angina, 1.09 (0.99 to 1.20) and stroke, 1.08 (0.86 to 1.31); and lower but not statistically significant for myocardial infarction, 0.91 (0.72 to 1.10); peripheral vascular disease, 0.81 (0.60 to 1.02); anemia, 0.86 (0.56 to 1.17); and depression, 0.89 (0.37 to 1.40). The mean change per 1,000 patients in admissions was less by 38 (P = 0.03) because of fewer readmissions, and in days was 1,309 less (P < 0.001), for patients treated with rHuEPO versus controls. The mean change per patient in hospital costs was $371 less and was statistically significant (P = 0.03) and in Medicare hospital payments was $132 less but was not statistically significant (P = 0.43) for patients treated with rHuEPO versus controls. rHuEPO was associated with an increase in the probability of hospital admission (particularly admissions potentially related to adverse effects) but a decrease in readmissions, overall admissions, hospital days, and cost to hospitals in this cohort of patients surviving for 18 mo. Although not realized short term, Medicare savings from potential rHuEPO-related reductions in hospital care may be long term through future adjustments in diagnosis-related group-based hospital payment. 相似文献
95.
Recently, the authors presented evidence that new items can be prioritized for selection by the top-down attentional inhibition of old stimuli already in the field (visual marking; D. G. Watson & G. W. Humphreys, 1997). In this article the authors assess whether this inhibition extends to moving old items and test an alternative account of visual marking. Six experiments showed that old moving items could be inhibited provided they did not undergo abrupt property changes. Further, and in contrast to effects with static stimuli, the marking of old moving stimuli was based on inhibition applied at the level of a whole feature map, rather than at their locations. The results also rule out an alternative account of visual marking based on the top-down weighting of dynamic or static processing pathways. 相似文献
96.
97.
A water cooled magnetron sputtering system has been successfully applied to the deposition of silver onto thin thermally fragile Mylar sheets. The sheets were stencil masked to provide a pattern of row and column conductors in a 64-cell membrane switch array which was intended for use in a microcomputer based aid for the handicapped. The specification for such a microcomputer scanned keyboard matrix is outlined and the design details given for a back-illuminated array of cross point switches. Test results indicate that the technique is potentially suitable for the production of low-profile, high reliability keyboards and other low resistivity flexible conductor applications. 相似文献
98.
Hugh J. Watson Margaret T. O'Hara Candice G. Harp Gigi G. Kelly 《Information Systems Management》1996,13(3):66-77
Although much of executive decision making is based on soft information—opinions, predictions, news, and even rumors—executive information systems (EISs) have only recently begun to augment factual data with such information. A study of current use of soft information in EISs yields 15 propositions designed to help EIS developers determine what kinds of soft information are most valuable and how best to capture and deliver this information. 相似文献
99.
100.
Identified a pathway from in-session process, and problem resolution, to post-session change and final outcome. Two brief treatments for depression, one using client-centered (CC) and the other process-experiential (PE) interventions, were compared on client process and outcome. The PE group showed significantly higher levels of experiencing, vocal quality and expressive stance, and greater problem resolution than the CC group in 2 of 3 PE interventions studied. Ss' degree of problem resolution correlated significantly with depth of experiencing, and sustained resolution over treatment resulted in better outcome. Ss' task-specific post-session change scores correlated significantly with change in depression post-therapy and 6 mo later, indicating that repeated post-session change is related to reduction in symptomatology. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献