Secondary prevention of ischemic heart disease after coronary revascularization

This study was aimed to assess the compliance with policies for secondary prevention of coronary heart disease (CHD) one year after coronary artery revascularization with special attention to the management of hyperlipidemia. One year after coronary revascularization during the year 1994, patients were contacted by letter to determine the modification of their risk factors, the treatment patterns for hypercholesterolemia and to have their plasma lipid level and blood pressure measured. Of the 245 consecutive patients contacted (110 after coronary artery bypass grafting, and 135 after percutaneous transluminal coronary angioplasty), 186 (76%) provided the information required for further analysis. Excluding the patients older than 65 years, only 29 out of 97 patients (30%) with a total cholesterol of more than 5.2 mmol/l, and only 20 out of 52 patients (38%) with a total cholesterol of more than 6.2 mmol/l were receiving lipid lowering therapy 1 year after coronary artery revascularization. In contrast, 97% (n = 180) of the entire population studied were taking antiplatelet drugs and/or coumadine. Participation in an in-house rehabilitation program yielded a positive influence on smoking, but not on treatment of hypercholesterolemia. In conclusion, only a small proportion of patients with documented CHD and hypercholesterolemia were being treated for their lipid disorder 1 year after coronary artery revascularization. In contrast, the great majority of patients received antiplatelet and/or coumadine therapy: These results indicate that the compliance with published treatment guidelines for hyperlipidemia in patients with CHD is still highly inadequate, irrespective of the participation in a rehabilitation program.     

Predictors of aggressive behaviors: a longitudinal study in senior day care centers

Aggressive behaviors place elderly persons and their caregivers at risk. This study examines longitudinally the predictors of aggressive behaviors based on staff and family members' ratings of 200 community-dwelling participants from senior day care centers. The main difference between physically and verbally aggressive behaviors was found to be the role of physical and mental health. Cognitive impairment and poor quality of relationship were the main predictors of physically aggressive behaviors. Verbally aggressive behaviors were predicted mainly by depressed affect, low quality of relationships, and poor physical health. These results validate and expand prior cross-sectional research on the correlates of aggression in other populations, and guide in the development of interventions.     

Current in-service inspections of austenitic stainless steel and dissimilar metal welds in light water nuclear power plants

A tendency towards growing requirements for the inspection of austenitic piping can be observed in several countries. In Germany the revised KTA rule demands the UT inspection of austenitic and dissimilar metal welds in piping with diameters of 200 mm or more.On the basis of experience gained from austenitic piping with integranular stress corrosion cracking (IGSCC), longitudinal waves and mode conversion techniques are used. Depending on the geometry, material and grain orientation, spurious signals can be observed which require additional evaluation or analysis measurements.A promising new technique is based on horizontally polarized shear (SH) waves generated by electromagnetic acoustic transducers (EMATs). Investigations in the laboratory and field inspections showed that SH waves are well suited for the detection of longitudinal flaws, especially where the weld can be examined from one side only.For the complete solution of a given inspection problem SH waves can be combined with well-known standard techniques in order to provide redundant information for the characterization and sizing of indications.The investigation of possibilities of SH waves showed that the problem of cast austenitic steel inspection might not be solved using this technique. However, measurements using low frequency UT transducers showed promising results.     

In vivo labelling of the mouse brain 5-hydroxytryptamine1A receptor with the novel selective antagonist 3H-NAD-299

The in vivo labelling of 5-hydroxytryptamine (5-HT)1A receptors in the mouse brain was studied with the novel selective 5-HT1A receptor antagonist, NAD-299 ((R)-3-N,N-dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1-benzopyran- 5-carboxamide hydrogen (2R,3R)-tartrate monohydrate). 3H-NAD-299 was injected in a tail vein and the radioactivity in various brain regions was determined. More than 90% of the radioactivity in hippocampus, 15 min after the injection, was intact NAD-299. At this time the amount of 3H-NAD-299 was highest in hippocampus followed by frontal cortex, mesencephalon, hypothalamus, striatum and cerebellum. The specific accumulation of radioactivity (after subtracting cerebellum values) in frontal cortex and hippocampus was maximal 10 to 30 min after the injection and had almost disappeared after 2 h. Saturation kinetics derived Bmax (pmol/g wet weight tissue) values of 19.6+/-2.0 in frontal cortex and 38.0+/-3.5 in hippocampus. The apparent Kd values expressed in nmol/kg 3H-NAD-299 injected, were 12.3+/-2.2 in frontal cortex and 20.3+/-3.1 in hippocampus. The 5-HT1A receptor antagonist, WAY-100,635 competitively inhibited the specific accumulation of 3H-NAD-299 and was about equipotent with unlabelled NAD-299 with ED50 values of 20-30 nmol/kg s.c. These compounds were about 10 times more potent than the 5-HT1A receptor antagonists, p-MPPI and NDL-249 and 100 times more potent than (S)-UH-301. 5-HT1A receptor agonists, e.g. 8-OH-DPAT and flesinoxan and partial agonists, e.g. pindolol, buspirone and ipsapirone had low potency in this in vivo assay. Spiperone and methiothepin inhibited the 3H-NAD-299 accumulation at 10 micromol/kg s.c. The alpha1-adrenoceptor antagonist, prazosin at 2 micromol/kg s.c. increased significantly the specific accumulation of 3H-NAD-299. Pretreatment of the mice with the non-selective, irreversible receptor antagonist, EEDQ produced a dose related long-lasting decrease in the accumulation of 3H-NAD-299. It is concluded that NAD-299 is a very suitable ligand for studies of 5-HT1A receptors in the brain in vivo.     

On the protective mechanisms of nitric oxide in acute pancreatitis

Nucleosome dimers from chicken erythrocytes show an ionic strength dependence of sedimentation coefficient similar to that of trimers, and indicative of a degree of compaction over a range of low ionic strengths. This is not easily reconciled with straight linkers but is consistent with bending or kinking of the linker DNA.     

Process model and resource management in a distributed database

A deadlock-free resource management for a homogeneous distributed database system is proposed. Consistent database access is guaranteed in sections called transactions. Transactions consist of several processes of hierarchical structure. Transactions with read-and write-operations use a two-phase locking. The read-resources are locked as they are needed. The write-operations are buffered and executed at the end of a transaction. At this point the write-resources can be locked in a given order. Transactions which only read the database, do not lock the resources. It is only checked if these transactions can be serialized. Conflicts are resolved by resetting of transactions. No expensive recovery is needed. No physical controlling centre is used.     

Evaluation of Antacids in Man Using the Heidelberg Capsule

Thirteen commercially available antacids in tablet form were tested in healthy young volunteers using a transistorized miniature telemetric device (Heidelberg Capsule). After the radio transmitter capsule was swallowed, an alkali response test was performed, and two tablets of the antacid to be tested then administered. The recorded pH versus time curves were evaluated for onset of action defined as increase of pH to a value above 3, the maximum pH obtained, and the area under the pH versus time curve after the alkali response test and after administration of the antacid. For the latter one two areas were determined, the one above the base line and that above pH 5.5. It has been determined that to be effective in ulcer patients an antacid should bring the gastric pH to a value of 5.5 or above at which point the proteolytic enzymes are inactive. Only 9 of the 13 preparations resulted in pH above 5.5. Dividing the areas under the curve above the base line after administration of the antacid by the area under the curve obtained after the alkali test the extent of antacid capacity (E.A.C.) or “potency” of the preparation is obtained. Only four of 13 antacids resulted in an E.A.C. of more than twice that found during the alkali test.     

Features that distinguish the smooth-pursuit eye-tracking performance of schizophrenic, affective-disorder, and normal individuals.

Examined the eye-tracking records of 25 schizophrenic (mean age 37.6 yrs), 25 unipolar (mean age 37.9 yrs), 24 bipolar (mean age 36 yrs), and 46 medical control (mean age 35 yrs) patients. All the psychiatric patients were in symptom remission. All three psychiatric groups produced more oscillations than controls, and spiky tracking was correlated with poor performance as indexed by the production of large saccades. Schizophrenics did, however, produce smaller saccades and tracked with more phase lag than did each of the other groups. Results suggest that the smooth-pursuit system of schizophrenics is functionally different from that of normal people. Use of the phase lag as a potential marker of schizophrenia is discussed. (33 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The effect of clotrimazole on the pathogen of toxoplasmosis, Toxoplasma gondii

A previous study showed activity of megestrol acetate in advanced breast cancer; as a result the study was expanded. Of 101 patients treated with this compound, 26 (26%) met our criteria of improvement. The drug was well tolerated and produced no toxicity and, as opposed to androgens and estrogens, no endocrine effects were observed. Prior hormonal or cytotoxic compounds, including alkylating agents, did not appear to reduce the subsequent responsiveness to this potent progestational compound. We now include it, often as the initial hormonal trial in postmenopausal patients, in our sequential treatment of disseminated breast cancer because of its favorable therapeutic ratio.