Managing your process hazards as a means of conforming to ohsa requirements

There is considerable evidence that improper changes have directly caused or through the “domino sequence” led to many of the major accidents that have occurred in the chemical process industry and related industries that use hazardous chemicals and technology. Central Government has recognised the importance of careful management of change(MOC) for ensuring the safety of chemical operations and the quality of manufactured goods by the proposed adding of the Major Hazardous Installation Regulation to the OHSA (Act 85 of 1993).

The concept and the need to properly manage change are not new; many companies have adopted MOC procedures. It is common practice nowadays to perform detailed risk assessments on any new or intended project to ensure safety and reliability of the project. Yet, incidents and near misses attributable to inadequate management of changes on existing systems and processes continue to occur. To improve the performance of MOC systems throughout industry, managers need advice on how to better institutionalise MOC systems within their companies and plants.

The purpose of this paper is to define the important features of MOC systems and to assist in the implementation and management of process hazards. MOC systems help ensure that changes to design and operation of company facilities will not adversely affect employees, the public, or the environment. This document outlines a process that can be used for designing, developing, installing, operating, and maintaining MOC systems at individual company sites.

This paper is intended for an audience ranging from plant and corporate managers of process safety to workers who have differing levels of knowledge about the principles of safely managing change. It is primarily designed to equip people responsible for MOC systems with new ideas for implementing and improving MOC systems. It was indeed a privilege to have met the personnel of JBF Associates, Inc. and Process Safety Institute in Knoxville, Tennessee, USA, without whose lectures and study material (including the book “Managing process changes”) this paper would never have seen the light. They have succeeded in putting me firmly on the “process safety road”.     

Evaluation of Serum Volume Losses During Long-Term Storage

Aliquots of serum collected in a large case-control study of cervical cancer were stored at −70°C for up to 4 years during implementation of the study. When 500 μL serum aliquots were thawed in preparation for carotenoid and vitamin A assays, volumes were noticeably variable and fell below 500 μL in the majority of the samples. We were concerned about evaporation/sublimation during storage of the samples because loss of water would concentrate the analytes of interest. We evaluated the use of density and sodium ion concentration measurements to confirm its occurrence. We found that serum density was an unreliable indicator of extent of volume loss since the anticipated increases in density due to evaporation were of the same magnitude as inter-individual variation in serum density. In contrast, Na⁺ concentration is tightly regulated and would rise if water had been lost from the samples. In a representative sample of serum aliquots from the case-control study, 24 of 25 vials contained less than 500 μL of serum. The mean sodium ion concentration (138.1 ± 3.6 mmol/L) was within the normal range for human serum of 136–145 mmol/L, and no correlation was observed between serum volume and Na⁺ concentration. These results strongly suggest that the observed low volumes were not due to evaporative losses. Instead, the variably low volumes of serum aliquots were probably due to pipetting errors in the initial aliquotting resulting from the use of air-displacement pipettes.     

Two CEGAR-based approaches for the safety verification of PLC-controlled plants

In this paper we address the safety analysis of chemical plants controlled by programmable logic controllers (PLCs). We consider a specification of the control program of the PLCs, extended with the specification of the dynamic plant behavior. The resulting hybrid models can be transformed to hybrid automata, for which advanced techniques for reachability analysis exist. However, the hybrid automata models are often too large to be analyzed. We propose two counterexample-guided abstraction refinement (CEGAR) approaches to keep the size of the hybrid models moderate.     

Transforming Perceived Vocal Effort and Breathiness Using Adaptive Pre-Emphasis Linear Prediction

This paper presents a technique to transform high-effort voices into breathy voices using adaptive pre-emphasis linear prediction (APLP). The primary benefit of this technique is that it estimates a spectral emphasis filter that can be used to manipulate the perceived vocal effort. The other benefit of APLP is that it estimates a formant filter that is more consistent across varying voice qualities. This paper describes how constant pre-emphasis linear prediction (LP) estimates a voice source with a constant spectral envelope even though the spectral envelope of the true voice source varies over time. A listening experiment demonstrates how differences in vocal effort and breathiness are audible in the formant filter estimated by constant pre-emphasis LP. APLP is presented as a technique to estimate a spectral emphasis filter that captures the combined influence of the glottal source and the vocal tract upon the spectral envelope of the voice. A final listening experiment demonstrates how APLP can be used to effectively transform high-effort voices into breathy voices. The techniques presented here are relevant to researchers in voice conversion, voice quality, singing, and emotion.     

Effect of a coalescing aid on the earliest stages of polymer diffusion in poly(butyl acrylate-co-methyl methacrylate) latex films

In this article we use fluorescence resonance energy transfer (FRET) to investigate how a classic coalescing aid, such as 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate (Texanol?) (TX), acts on the earliest stages of polymer diffusion as the latex film is still drying. In our approach, we temporarily arrest the drying process of a partially wet latex film by sealing it in an airtight chamber previously cooled to near the latex T_g. At these conditions, we are able to effectively stop the drying process and the polymer diffusion. FRET measurements at various locations on such a sample provide us information about the mechanism operating at the initial stages of polymer diffusion as the latex film is still drying. We complete our study with FRET measurements carried out at longer aging times on predried latex films. We analyze our diffusion data in terms of free volume theory and propose a mechanism that can account for the results obtained.     

Insights on Ceramics as Dental Materials. Part II: Chemical Surface Treatments

The purpose of surface treatment (conditioning) methods on dental ceramics is to improve the retention and bonding between the enamel or the dentin and ceramic veneer, with the help of resin composite luting cements. These types of surface treatments include chemically altering the surface of ceramics with some specific acidic etchants followed by applying a silane coupling agent (silane). The silane currently used in dentistry is 3-methacryloxypropyltrimethoxysilane, a hybrid organic–inorganic trialkoxy ester monomer, which is diluted in an acidified water-ethanol solvent system. Such silane primers are said to be pre-hydrolyzed. Some oxide ceramics with high crystalline content, such as alumina and zirconia, cannot be easily etched with acid etchants. They should be silica-coated and silanized prior to bonding. A silane coupling agent should be applied after silica-coating to the ceramic surface to achieve chemical bonding and the optimal durable bond strength.     

Cocoa-butter long spacings and the memory effect

Depending on the maximum temperature before cooling, cocoa butter recrystallizes in the β(V) and/or β(VI) phase. In order to obtain structural information on the seed material initiating this recrystallization process, experiments with cocoa butter were performed at a small-angle X-ray scattering station. Crystallization of cocoa butter at various crystallization temperatures provided long d-spacing values (d>45 Å) that can be attributed to the polymorphic phases. From the recrystallization experiments it is concluded that the seeds initiating rapidstarting recrystallization have an 1,3-distearoyl-2-oleoylglycerol-dominated triple chain-length packing. Furthermore, the β(VI) phase of cocoa butter seems to adopt a similar packing. The seed crystals that initiate the slow-starting recrystallization and result in the β(V) phase are likely to be different from those giving the β(VI) phase.     

Polymerization of methyl methacrylate with a thermal iniferter: Diethyl 2,3‐dicyano‐2,3‐di(p‐tolyl)succinate

A hexa‐substituted ethane type compound, diethyl‐2,3‐dicyano‐2,3‐di(p‐tolyl)succinate (DCDTS), was successfully synthesized and used for initiation of methyl methacrylate (MMA) polymerization. The reaction demonstrated the characteristics of a “living” polymerization; i.e., both the yield and the molecular weight of the resulting polymers increased linearly with increasing reaction time, the molecular‐weight distribution of PMMA obtained was ～1.60 and almost unaffected by the conversion, and the resultant polymer can be chain extended by adding fresh MMA. End group analysis of the resultant PMMA confirmed that DCDTS behaves as a thermal iniferter for MMA polymerization. A block copolymer was prepared from the resultant PMMA, which contains a hexa‐substituted C? C bond functional end group. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 80: 2566–2572, 2001     

放电等离子烧结对纳米TiN增强Ti-6Al-4V显微组织和磨损行为的影响（英文）

采用放电等离子烧结(SPS)成功制备Ti-6Al-4V/TiN复合材料。加入Ti-6Al-4V中的TiN含量变化范围为1%~5%(体积分数)。研究添加TiN对Ti-6Al-4V材料致密度、显微组织、硬度和磨损行为的影响。实验结果表明,随着TiN含量的增加,材料的烧结密度从99%降低至97%;而显微硬度值却从HV_(0.1) 389增加至HV_(0.1) 488。X射线衍射(XRD)分析表明,伴随着少量二次Ti_2N相的形成,复合材料中TiN相的衍射峰强度增加。SEM分析表明,SPS烧结Ti-6Al-4V纳米复合材料具有细化的α/β相组织及均匀分散的TiN颗粒。与无添加烧结Ti-6Al-4V相比,Ti-6Al-4V/TiN复合材料的磨损表面呈现非连续的凹槽,抗磨粒磨损性能得到提高。     

Enhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study

Distraction osteogenesis (DO) is a mechanobiological process of producing new bone and overlying soft tissues through the gradual and controlled distraction of surgically separated bone segments. The process of bone regeneration during DO is largely affected by distraction parameters. In the present study, a distraction strategy with varying distraction rates (i.e., “rate-varying distraction”) is proposed, with the aim of shortening the distraction time and improving the efficiency of DO. We hypothesized that faster and better healing can be achieved with rate-varying distractions, as compared with constant-rate distractions. A computational model incorporating the viscoelastic behaviors of the callus tissues and the mechano-regulatory tissue differentiation laws was developed and validated to predict the bone regeneration process during DO. The effect of rate-varying distraction on the healing outcomes (bony bridging time and bone formation) was examined. Compared to the constant low-rate distraction, a low-to-high rate-varying distraction provided a favorable mechanical environment for angiogenesis and bone tissue differentiation, throughout the distraction and consolidation phase, leading to an improved healing outcome with a shortened healing time. These results suggest that a rate-varying clinical strategy could reduce the overall treatment time of DO and decrease the risk of complications related to the external fixator.