Effect of pregnenolone sulfate on delayed rectifier K+ channel in pyramidial neuron of cerebral cortex

The possible preventive effect of Kampo medicine Hange-shashin-to (TJ-14) on chronic diarrheal symptoms induced by the administration of the anticancer agent irinotecan hydrochloride (CPT-11) was investigated in the rat. Repeated oral administrations of TJ-14 at 125 and 500 mg/kg significantly prevented the reduction in body weight and the onset of chronic diarrheal symptoms due to CPT-11 in a dose-dependent manner, even though it failed to show a definite effect on acute diarrheal symptoms. In addition, treatment with TJ-14 accelerated the healing of the intestinal tract injured by repeated dosing of CPT-11 and inhibited significantly the increase of colonic prostaglandin E2 (PGE2) which is closely related to the onset of diarrhea. TJ-14 also improved colonic water absorption impaired by repeated dosing of CPT-11 in rats. These results demonstrate that TJ-14 is an effective medicine for the prevention and/or treatment of CPT-11-induced chronic diarrheal symptoms.     

建筑业企业技术创新效率评价研究——基于 DEA 方法的实证分析

对于建筑业企业普遍存在技术创新效率低的问题,从创新效率评价的研究现状出发,运用数据包络分析法（DEA）对建筑业企业技术创新效率做出评价与分析。结果表明,建筑业企业创新综合效率偏低,不同类型企业创新效率差异较大,规模效率是导致创新综合效率偏低的主要因素;多数企业呈规模报酬递增态势,科研人员、企业内部技术创新经费投入过少是建筑业企业规模效率偏低的主要原因。并针对提高建筑业企业创新效率提出相应建议。     

四溴双酚A热解过程中溴化氢逸出特性研究

利用溴化氢逸出装置研究含溴材料四溴双酚A热解过程中溴化氢的逸出规律。结果表明:四溴双酚A热解过程中,气氛、热解温度、停留时间、空气流量和升温速率对溴化氢逸出影响显著。空气气氛下溴化氢释放率显著高于氮气气氛下。随着升温速率的增加,溴化氢的释放量呈线性减少的趋势。热解温度的升高、停留时间的延长和空气流量的增加在一定范围内会使溴化氢的释放量增加,超过一定值后又会抑制溴化氢的逸出。     

涡旋压缩机工作过程模拟及传热分析

根据涡旋压缩机的运转规律,得到了绝热状态涡旋压缩机非定常流动的数值模拟计算方法;对涡旋压缩机理论计算模型进行网格无关性验证、动网格重构验证,保证其数值模拟计算结果的准确性.得到了涡旋压缩机工作过程的压力场、温度场、速度场分布规律,得到其工作过程曲线与各工作腔的泄漏规律,并与理论绝热过程进行对比,验证了所采用的数值模拟计算方法的正确可行性.进而探究考虑流热耦合传热的涡旋压缩机工作过程的数值模拟计算方法,提出通过合理地设置壁面热力条件参数实现涡旋压缩机达到热力平衡状态的数值模拟计算方法.     

基于文献计量学的地下水污染研究现状

为了解国内外地下水污染领域研究现状和重点,梳理2009-2019年国内外学术期刊收录的地下水污染领域高质量文献8 117篇,利用可视化软件CiteSpace V.5.6.R3绘制科学知识图谱。通过对地下水研究领域论文发文量、研究内容、研究机构和发文作者统计、聚类和可视化,多维度发掘地下水污染研究的整体形势。结果显示:地下水污染研究领域科研论文发文量总体呈增长趋势,研究重点主要围绕污染物特征、污染评价和污染修复等3个方面开展,硝酸盐、砷污染已成为地下水污染的研究重点;中国地质科学院水文地质环境地质研究所和吉林大学对国内地下水污染领域的发展具有重要贡献,且研究团队随时间呈分散式、多元化发展;中国地质大学、中国科学院和美国地质调查局是最具国际影响力的机构,中国地质大学(武汉)王焰新院士团队在地下水污染研究领域极具国际影响力。在我国生态文明建设需求下,地下水污染修复由理论研究向污染场地应用转化仍是当前研究的趋势。     

非定常Stokes问题解的存在唯一性的正则性

引入Ｆａｄｅｏ－Ｇａｌｅｒｋｉｎ方法解决了三维非定常半周期Ｓｔｏｋｅｓ问题解的存在唯一性问题，在加强了初始条件后，得到了解的正则性结果。     

一种新型无芯PCB 平面电感器研究

本文主要介绍了在印制板上制作无芯电感的方法，分析了其结构和性能，并采用数值计算方法建立了平面电感计算模型，为设计电感提供了一条切实可行的途径。采用现代化的印制板技术，可以精确地控制电感器的绕线宽度、线间距，克服了机器绕线一致性差的缺点，并使电感从三维向两维发展，为器件的表面贴装打下了基础。     

Mineralized bone loss at different sites in dialysis patients: implications for prevention

To characterize the magnitude and location of mineralized bone loss, 40 patients (20 men, 20 women, 29 white, 11 black) with clinically significant renal osteodystrophy who could be unambiguously classified based on histologic criteria as having osteitis fibrosa (OF; 20 cases) or osteomalacia (OM; 20 cases) were studied; they had been on maintenance hemodialysis for 4.6 +/- 3.0 yr. One hundred forty-two healthy women of similar age and ethnic composition served as control subjects. In all subjects, the proportions of mineralized bone, osteoid, and porosity (nonbone soft tissue) were measured separately in cortical and cancellous bone tissue, from intact full-thickness biopsies of the ilium, representative of the axial skeleton. The results were related to the volumes of cortical and cancellous bone tissue separately and to the volume of the entire biopsy core. Approximately three-quarters of the patients had measurements in the appendicular skeleton by single photon absorptiometry of the radius and morphometry of the metacarpal. Disease effects did not differ significantly between ethnic groups. Mineralized cortical bone volume (per unit of core volume) was reduced by approximately 45% in both patient groups. Mineralized cancellous bone volume was significantly increased by 36% in the patients with OF and nonsignificantly reduced by 9% in the patients with OM; however, the reduction in the latter patients was significant in relation to tissue volume. The combined total deficit for both types of iliac bone was approximately 20% in the patients with OF and approximately 40% in the patients with OM. Significant reductions in appendicular cortical bone were demonstrated in both patient groups at both measurement sites. Regardless of the current histologic classification, the major structural abnormality in the skeleton is generalized thinning of cortical bone due to increased net endocortical resorption, the most characteristic effect on bone of hyperparathyroidism. Protection of the skeleton from the adverse consequences of renal failure will require therapeutic intervention in patients with no symptoms of either renal or bone disease.