全文获取类型
收费全文 | 206747篇 |
免费 | 2994篇 |
国内免费 | 659篇 |
专业分类
电工技术 | 3671篇 |
综合类 | 170篇 |
化学工业 | 30565篇 |
金属工艺 | 8203篇 |
机械仪表 | 6241篇 |
建筑科学 | 5043篇 |
矿业工程 | 1312篇 |
能源动力 | 5622篇 |
轻工业 | 17849篇 |
水利工程 | 2382篇 |
石油天然气 | 4185篇 |
武器工业 | 12篇 |
无线电 | 23972篇 |
一般工业技术 | 41330篇 |
冶金工业 | 37661篇 |
原子能技术 | 5160篇 |
自动化技术 | 17022篇 |
出版年
2021年 | 2115篇 |
2020年 | 1525篇 |
2019年 | 1933篇 |
2018年 | 3039篇 |
2017年 | 2973篇 |
2016年 | 3148篇 |
2015年 | 2025篇 |
2014年 | 3425篇 |
2013年 | 9514篇 |
2012年 | 5425篇 |
2011年 | 7452篇 |
2010年 | 5866篇 |
2009年 | 6586篇 |
2008年 | 6665篇 |
2007年 | 6708篇 |
2006年 | 5741篇 |
2005年 | 5373篇 |
2004年 | 5129篇 |
2003年 | 4985篇 |
2002年 | 4640篇 |
2001年 | 4714篇 |
2000年 | 4640篇 |
1999年 | 4800篇 |
1998年 | 11496篇 |
1997年 | 8226篇 |
1996年 | 6474篇 |
1995年 | 4744篇 |
1994年 | 4323篇 |
1993年 | 4122篇 |
1992年 | 3260篇 |
1991年 | 3098篇 |
1990年 | 2897篇 |
1989年 | 2990篇 |
1988年 | 2869篇 |
1987年 | 2422篇 |
1986年 | 2338篇 |
1985年 | 2756篇 |
1984年 | 2553篇 |
1983年 | 2386篇 |
1982年 | 2116篇 |
1981年 | 2222篇 |
1980年 | 2057篇 |
1979年 | 2147篇 |
1978年 | 2138篇 |
1977年 | 2383篇 |
1976年 | 3215篇 |
1975年 | 1848篇 |
1974年 | 1776篇 |
1973年 | 1784篇 |
1972年 | 1456篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
P. Carrasqueira H. Rocha J. M. Dias T. Ventura B. C. Ferreira M. C. Lopes 《International Transactions in Operational Research》2023,30(1):206-223
Radiation therapy is a technology-driven cancer treatment modality that has experienced significant advances over the last decades, due to multidisciplinary contributions that include engineering and computing. Recent technological developments allow the use of noncoplanar volumetric modulated arc therapy (VMAT), one of the most recent photon treatment techniques, in clinical practice. In this work, an automated noncoplanar arc trajectory optimization framework designed in two modular phases is presented. First, a noncoplanar beam angle optimization algorithm is used to obtain a set of noncoplanar irradiation directions. Then, anchored in these directions, an optimization strategy is proposed to compute an optimal arc trajectory. The computational experiments considered a pool of twelve difficult head-and-neck tumor cases. It was possible to observe that, for some of these cases, the optimized noncoplanar arc trajectories led to significant treatment planning quality improvements, when compared with coplanar VMAT treatment plans. Although these experiments were done in a research environment treatment planning software (matRad), the conclusions can be of interest for a clinical setting: automated procedures can simplify the current treatment workflow, produce high-quality treatment plans, making better use of human resources and allowing for unbiased comparisons between different treatment techniques. 相似文献
52.
El-Denglawey A. Issa Shams A. M. Saddeek Yasser B. Tekin H. O. Zakaly Hesham M. H. 《Journal of Inorganic and Organometallic Polymers and Materials》2021,31(10):3934-3942
Journal of Inorganic and Organometallic Polymers and Materials - This work aimed to investigate the impact of Lead-fluoride based glasses via theoretical and simulation techniques on mechanical and... 相似文献
53.
Kozhitov L. V. Kiselev B. G. Raykova T. B. Popkova A. V. Kostishin V. G. Muratov D. G. Yakushko E. V. Kosushkin V. G. Bebenin V. G. 《Russian Microelectronics》2019,48(8):599-612
Russian Microelectronics - The recently developed nanomaterials and their production technologies as intellectual property objects (IPOs) are considered. The role of the informational-analytical... 相似文献
54.
55.
Mining high utility itemsets (HUIs) from transaction databases considers such factors as the unit profit and quantity of purchased items. Two-phase tree-based algorithms transform a database into compressed tree structures and generate candidate patterns through a recursive pattern-growth procedure. This procedure requires a lot of memory and time to construct conditional pattern trees. To address this issue, this study employs two compressed tree structures, namely, Utility Count Tree and String Utility Tree, to enumerate valid patterns and thus promote fast utility computation. Furthermore, the study presents an algorithm called single-phase utility computation (SPUC) that leverages these two tree structures to mine HUIs in a single phase by incorporating novel pruning strategies. Experiments conducted on both real and synthetic datasets demonstrate the superior performance of SPUC compared with IHUP, UP-Growth, and UP-Growth+ algorithms. 相似文献
56.
Chertkov Yu. B. Anikin M. N. Lebedev I. I. Naimushin A. G. Smol’nikov N. V. 《Atomic Energy》2021,131(1):42-45
Atomic Energy - The results of calculations and experimental determination of the neutronics characteristics of the IRT-T research reactor are presented. The IRT-T reactor is a pool reactor with... 相似文献
57.
This paper considers the state‐dependent interference relay channel (SIRC) in which one of the two users may operate as a secondary user and the relay has a noncausal access to the signals from both users. For discrete memoryless SIRC, we first establish the achievable rate region by carefully merging Han‐Kobayashi rate splitting encoding technique, superposition encoding, and Gelfand‐Pinsker encoding technique. Then, based on the achievable rate region that we derive, the capacity of the SIRC is established in many different scenarios including (a) the weak interference regime, (b) the strong interference regime, and (c) the very strong interference regime. This means that our capacity results contain all available known results in the literature. Next, the achievable rate region and the associated capacity results are also evaluated in the case of additive Gaussian noise. Additionally, many numerical examples are investigated to show the value of our theoretical derivations. 相似文献
58.
Myriam Gonzlez María Ovejero-Snchez Alba Vicente-Blzquez Raquel lvarez Ana B. Herrero Manuel Medarde Rogelio Gonzlez-Sarmiento Rafael Pelez 《International journal of molecular sciences》2021,22(4)
Pan-Gyn cancers entail 1 in 5 cancer cases worldwide, breast cancer being the most commonly diagnosed and responsible for most cancer deaths in women. The high incidence and mortality of these malignancies, together with the handicaps of taxanes—first-line treatments—turn the development of alternative therapeutics into an urgency. Taxanes exhibit low water solubility that require formulations that involve side effects. These drugs are often associated with dose-limiting toxicities and with the appearance of multi-drug resistance (MDR). Here, we propose targeting tubulin with compounds directed to the colchicine site, as their smaller size offer pharmacokinetic advantages and make them less prone to MDR efflux. We have prepared 52 new Microtubule Destabilizing Sulfonamides (MDS) that mostly avoid MDR-mediated resistance and with improved aqueous solubility. The most potent compounds, N-methyl-N-(3,4,5-trimethoxyphenyl-4-methylaminobenzenesulfonamide 38, N-methyl-N-(3,4,5-trimethoxyphenyl-4-methoxy-3-aminobenzenesulfonamide 42, and N-benzyl-N-(3,4,5-trimethoxyphenyl-4-methoxy-3-aminobenzenesulfonamide 45 show nanomolar antiproliferative potencies against ovarian, breast, and cervix carcinoma cells, similar or even better than paclitaxel. Compounds behave as tubulin-binding agents, causing an evident disruption of the microtubule network, in vitro Tubulin Polymerization Inhibition (TPI), and mitotic catastrophe followed by apoptosis. Our results suggest that these novel MDS may be promising alternatives to taxane-based chemotherapy in chemoresistant Pan-Gyn cancers. 相似文献
59.
60.
Daniela Frasca Maria Romero Alain Diaz Denisse Garcia Seth Thaller Bonnie B. Blomberg 《International journal of molecular sciences》2021,22(4)
Senescent cells accumulate in the adipose tissue (AT) of individuals with obesity and secrete multiple factors that constitute the senescence-associated secretory phenotype (SASP). This paper aimed at the identification of B cells with a SASP phenotype in the AT, as compared to the peripheral blood, of individuals with obesity. Our results show increased expression of SASP markers in AT versus blood B cells, a phenotype associated with a hyper-metabolic profile necessary to support the increased immune activation of AT-derived B cells as compared to blood-derived B cells. This hyper-metabolic profile is needed for the secretion of the pro-inflammatory mediators (cytokines, chemokines, micro-RNAs) that fuel local and systemic inflammation. 相似文献