Glutamine dipeptide attenuate mucosal atrophic changes and preservation of gut barrier function following 5-FU intervention

Traditional parenteral nutrition (PN) and chemotherapy may lead to changes mucosal morphology and gut barrier function. To investigate the effects of alanyl-glutamine on intestinal mucosal morphology and gut barrier function in PN-fed rats challenged with 5-FU male Wistar rats were central catheterized and randomily divided into two groups: PN group (n = 10) that received traditional parenteral nutrition solution only, and Ala-Gln group (n = 10) that received glutamine dipeptide enriched nutritional solution (3% Ala-Gln). The rats were maintained on their respective diets for 7 days. 5-FU (75 mg/kg) was injected intraperitoneally at 8 am on day 4. All rats were gavaged with lactulose (100 mg) and mannitol (50 mg) in 2ml before and three days after administration of 5-FU. Ala-Gln group maintained serum glutamine concentration, intestinal mucosal morphology. While bacterial translocation rates in ala-Gln group was 30%, in PN group was 90% (P < 0.05). Similar intestinal permeability was observed on day 3 in both groups. The control group had a significantly increased intestinal permeability on day 7 (P < 0.05), while Ala-Gln group maintained the intestinal permeability. It was suggested that alanyl-glutamine maintained intestinal morphology and gut barrier function in PN-fed rats challenged with 5-FU.     

添加微量锡对铜基摩擦材料性能的影响

研究了添加微量锡对铜基摩擦的摩擦性能的影响。结果表明，微量锡对摩擦系数无显著影响，但对磨损有显著影响，当锡含量为０．５０％时，摩擦材料及对偶材料的磨损都较小。     

双马来酰亚胺基体树脂的改性研究

本文报道用改性物B改善双马来酰亚胺/二胺预聚物溶解性的实验研究.结果表明,改性后的双马来酰亚胺/二胺基体树脂在低沸点、低毒性溶剂如丙酮中具有良好的溶解性,并且有足够的均相期,为湿法制作预浸料创造了有利条件.同时对树脂的固化反应、耐热稳定性及其复合材料在高温条件下(150℃、200℃)的层间剪切性能进行了研究.     

清水砼技术在民用建筑中的应用——浅谈建设项目如何应用新技术

本文通过介绍清水砼技术在民用建筑中的应用,对建设项目如何应用新技术进行探讨。     

在役生产装置安全评价存在的职业卫生问题

分析了在役生产装置安全评价存在的职业卫生问题,提出了如何做好重点生产装置职业病预防工作的建议。     

基于MSP430F413 MCU的IC卡煤气表的设计与实现

提出了以TI公司MSP430系列MCU为基础的IC卡煤气表的设计思想，给出了总体设计，硬件电路设计，软件流程设计及主要模块的编程框架，讨论了低功耗问题。同时，对IC卡煤气表设计中一些应注意的问题也进行了简要的阐述。     

构建本科院校质量保障体系

近年来，新建本科院校取得了快速发展。本文结合工作实际，就新建本科院校如何尽快完成角色转变，建立健全自身的人才培养质量保障体系进行了分析和研究。     

Mechanisms responsible for resistance of sublines derived from leukemia cell lines to an antitumor agent 9-beta-D-arabinofuranosyl-2-fluoroadenine

An agent 9-beta-D-arabinofuranosyl-2-fluoroadenine (2-F-Ara-A) is a main metabolite of fludarabine, a fluorinated purine analogue with antitumor activity in lymphoproliferative malignancies. In this study, the mechanism responsible for the resistance of cancer cells to fludarabine was examined using the 2-F-Ara-A-resistant sublines JOK-1/F-Ara-A and L1210/F-Ara-A from a human hairy leukemic cell line (JOK-1) and a mouse leukemic cell line (L1210) respectively, which were established by continuous treatment of the parental cell lines with 2-F-AraA. JOK-1/F-Ara-A and L1210/F-Ara-A cells were more than 55 and 29 times more resistant to 2-F-Ara-A than were their parent cell lines, and showed a high cross-resistance to 1-beta-D-arabinofuranosylcytosine but not to doxorubicin or vincristine. These resistant sublines intracellularly accumulated almost the same amount of 2-F-Ara-A as did their parent cell lines. However, the amount of 2-F-Ara-ATP, a cytotoxic metabolite of 2-F-Ara-A, decreased by 2.6% (JOK-1/F-Ara-A C3), 6% (L1210/F-Ara-A C1) and 3.7% (L1210/F-Ara-A C7) relative to the levels in the parent cell lines. Enzymatically, these resistant cells hardly activated deoxycytidine (dCyd) and 2-F-Ara-A. In addition, the abilities to phosphorylate deoxyadenosine and deoxyguanosine were also decreased in the resistant cells in comparison with the parent cells. These findings suggest that the deficiency in activity of dCyd kinase may contribute to the resistance of 2-F-Ara-A.     

模糊自适应的高超飞行器控制与干扰

针对具有超大飞行马赫数、超宽飞行包络、飞行环境复杂等特点的高超声速飞行器,提出了基于模糊自适应的高超飞行器高度控制方法,分别设计了高度和速度控制器.针对所设计的控制器,分析了气动干扰力矩、测量噪声、舵机干扰、气动参数不确定性和飞行器模型参数不确定性对飞行器高度控制和速度控制效果的影响,然后又分析了综合考虑以上干扰和不确定性对飞行器高度控制和速度控制效果的影响.仿真结果表明,对各种干扰和不确定性,所设计的控制器速度和高度控制有较好的跟踪性和鲁棒性,达到了满意的效果.