On efficient deterministic simulation of turing machine computations below logaspace

It is shown that a bounded language accepted by a nondeterministic Turing machine in spaceS(n o(logn) can be accepted by a deterministic Turing machine in space MAX {(s(nn))², logn}. This can be interpreted as extending Savitch's algorithm below logspace. Results of Alt can be used to show that in the general case the indicated space bound cannot be improved. The result can also be interpreted as a sharpening in the special case of bounded languages of the results of Monien and Sudborough.     

Just how insoluble are monoterpenes?

Prior generalizations about the ecological roles of monoterpenes may be misleading if based on the presumed insolubility of monoterpenes in water. We determined the aqueous solubility of 31 biologically active monoterpenes by gas chromatography. While hydrocarbons were of low solubility (< 35 ppm), oxygenated monoterpenes exhibited solubilities one or two orders of magnitude higher, with ranges of 155–6990 ppm for ketones and of 183–1360 ppm for alcohols. Many monoterpenes are phytotoxic in concentrations under 100 ppm, well below the saturated aqueous concentrations of oxygenated monoterpenes. Therefore, even dilute, unsaturated solutions of monoterpenes, occurring naturally in plant tissues and soil solutions, may act as potent biological inhibitors.     

Role of sample size in the nucleation kinetics of phase transformations in steel alloys

Certain commercial steel alloys exhibit a two-step phase transformation process during solidification when substantial undercooling of the liquid allows access to the metastable phase. This two-step transformation leads to a desirable microstructure under certain conditions. Electrostatic Levitation (ESL) and Electromagnetic Levitation (EML) are two methods of containerless processing used to study how nucleation and growth kinetics influence the transformation delay between phases. Because the two facilities show substantially different delay results, the test environment differences have been analyzed to determine the root cause of this deviation. In particular, the difference in sample size between ESL and EML is examined and modeling shows that this difference is not the controlling factor in determining transformation delay behavior.     

Development of a measure for the information technology infrastructure construct

The goal of this research was to operationalize the information technology infrastructure (ITI) concept by identifying its underlying dimensions and establishing a valid and reliable measure for the construct. In order to accomplish this task with the highest degree of certainty, two approaches were sequentially applied: exploratory factor analysis and confirmatory factor analysis. In evaluating the confirmatory factor model, a step-by-step process was employed, assessing unidimensionality, reliability, discriminant validity, and nomological validity. The dimensions of ITI were determined to be: Chief Information Officer, IT Planning, IT Security, Technology Integration, Advisory Committee, Enterprise Model, and Data Administration. Researchers may now make use of this validated ITI measure to conduct investigations of ITI and other organizational measures. Implications of the ITI measure with other organizational initiatives such as electronic commerce and knowledge management are explored.     

Attending to the Omissions: A Historical Examination of Evidence-Based Practice Movements.

Evidence-based practice and empirically supported treatment movements are potent forces that affect the practice of psychology today and have the potential to mandate the types of treatments psychologists conduct. The histories of these movements reveal that certain aspects of therapy valued by psychologists have been ignored. It is shown that the evidence-based movements (a) overemphasize treatments and treatment differences and (b) ignore aspects of psychotherapy that have been shown to be related to outcome, such as variation among psychologists, the relationship, and other common factors. It is important that psychologists understand the development of these movements so that they can be critical consumers of research and can effectively influence the future course of events. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

ILB®, a Low Molecular Weight Dextran Sulphate,Restores Glutamate Homeostasis,Amino Acid Metabolism and Neurocognitive Functions in a Rat Model of Severe Traumatic Brain Injury

In a previous study, we found that administration of ILB^®, a new low molecular weight dextran sulphate, significantly improved mitochondrial functions and energy metabolism, as well as decreased oxidative/nitrosative stress, of brain tissue of rats exposed to severe traumatic brain injury (sTBI), induced by the closed-head weight-drop model of diffused TBI. Using aliquots of deproteinized brain tissue of the same animals of this former study, we here determined the concentrations of 24 amino acids of control rats, untreated sTBI rats (sacrificed at 2 and 7 days post-injury) and sTBI rats receiving a subcutaneous ILB^® administration (at the dose levels of 1, 5 and 15 mg/kg b.w.) 30 min post-impact (sacrificed at 2 and 7 days post-injury). Additionally, in a different set of experiments, new groups of control rats, untreated sTBI rats and ILB^®-treated rats (administered 30 min after sTBI at the dose levels of 1 or 5 mg/kg b.w.) were studied for their neurocognitive functions (anxiety, locomotor capacities, short- and long-term memory) at 7 days after the induction of sTBI. Compared to untreated sTBI animals, ILB^® significantly decreased whole brain glutamate (normalizing the glutamate/glutamine ratio), glycine, serine and γ-aminobutyric acid. Furthermore, ILB^® administration restored arginine metabolism (preventing nitrosative stress), levels of amino acids involved in methylation reactions (methionine, L-cystathionine, S-adenosylhomocysteine), and N-acetylaspartate homeostasis. The macroscopic evidences of the beneficial effects on brain metabolism induced by ILB^® were the relevant improvement in neurocognitive functions of the group of animals treated with ILB^® 5 mg/kg b.w., compared to the marked cognitive decline measured in untreated sTBI animals. These results demonstrate that ILB^® administration 30 min after sTBI prevents glutamate excitotoxicity and normalizes levels of amino acids involved in crucial brain metabolic functions. The ameliorations of amino acid metabolism, mitochondrial functions and energy metabolism in ILB^®-treated rats exposed to sTBI produced significant improvement in neurocognitive functions, reinforcing the concept that ILB^® is a new effective therapeutic tool for the treatment of sTBI, worth being tested in the clinical setting.     

Characterization of the Basal and mTOR-Dependent Acute Pulmonary and Systemic Immune Response in a Murine Model of Combined Burn and Inhalation Injury

Severe burn injury leads to a cascade of local and systemic immune responses that trigger an extreme state of immune dysfunction, leaving the patient highly susceptible to acute and chronic infection. When combined with inhalation injury, burn patients have higher mortality and a greater chance of developing secondary respiratory complications including infection. No animal model of combined burn and inhalation injury (B+I) exists that accurately mirrors the human clinical picture, nor are there any effective immunotherapies or predictive models of the risk of immune dysfunction. Our earlier work showed that the mechanistic/mammalian target of rapamycin (mTOR) pathway is activated early after burn injury, and its chemical blockade at injury reduced subsequent chronic bacterial susceptibility. It is unclear if mTOR plays a role in the exacerbated immune dysfunction seen after B+I injury. We aimed to: (1) characterize a novel murine model of B+I injury, and (2) investigate the role of mTOR in the immune response after B+I injury. Pulmonary and systemic immune responses to B+I were characterized in the absence or presence of mTOR inhibition at the time of injury. Data describe a murine model of B+I with inhalation-specific immune phenotypes and implicate mTOR in the acute immune dysfunction observed.     

QUANTITATIVE ANALYSES OF BEER BITTERING SUBSTANCES AND HOP RESINS BY THIN-LAYER CHROMATOGRAPHY

A simple thin-layer chromatographic procedure for the quantitative analysis of beer bittering substances is described. In the beers examined, 88–100% of the Brenner determination can be attributed to isohumulones A and B and the ratios of these two isomers show a real variation. Alpha-acids have been shown to be present in our beers. Thin-layer chromatography has also been adapted for analysis of hop resins and with fresh hops excellent agreement has been obtained with the conductometric method of analysis.     

低DCR检测电流模式控制器比电压模式控制器有更多优势

新一代微处理器和DSP需要以更低的工作电压提供更大的电流,因此电流检测元件的电阻需要尽可能小,以最大限度地降低电源传导损耗。然而,低电阻电流检测元件产生的斜坡电压较低,这在使用电流模式控制器时,不利于稳定运行。低斜坡电压导致采用电流模式控制方法的开关电源有显著抖动,在很多应用中,开关电源可能变得不稳定。因此,通常由电压模式控制器取而代之,尽管电压模式控制器也有不足之处,并可能出现可靠性问题。本文提出了一种新的电流模式双输出DC/DC降压型控制器,解决了此问题。