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991.
Federico Biscetti Elisabetta Nardella Maria Margherita Rando Andrea Leonardo Cecchini Antonio Gasbarrini Massimo Massetti Andrea Flex 《International journal of molecular sciences》2021,22(4)
Peripheral artery disease (PAD) is a manifestation of atherosclerosis, which may affect arteries of the lower extremities. The most dangerous PAD complication is chronic limb-threatening ischemia (CLTI). Without revascularization, CLTI often causes limb loss. However, neither open surgical revascularization nor endovascular treatment (EVT) ensure long-term success and freedom from restenosis and revascularization failure. In recent years, EVT has gained growing acceptance among all vascular specialties, becoming the primary approach of revascularization in patients with CLTI. In clinical practice, different clinical outcomes after EVT in patients with similar comorbidities undergoing the same procedure (in terms of revascularization technique and localization of the disease) cause unsolved issues that need to be addressed. Nowadays, risk management of revascularization failure is one of the major challenges in the vascular field. The aim of this literature review is to identify potential predictors for lower extremity endovascular revascularization outcomes and possible prevention strategies. 相似文献
992.
Giuseppe Pepe Maria Cotugno Federico Marracino Susy Giova Luca Capocci Maurizio Forte Rosita Stanzione Franca Bianchi Simona Marchitti Alba Di Pardo Sebastiano Sciarretta Speranza Rubattu Vittorio Maglione 《International journal of molecular sciences》2021,22(7)
Alterations in the metabolism of sphingolipids, a class of biologically active molecules in cell membranes with direct effect on vascular homeostasis, are increasingly recognized as important determinant in different vascular disorders. However, it is not clear whether sphingolipids are implicated in the pathogenesis of hypertension-related cerebrovascular and renal damage. In this study, we evaluated the existence of possible abnormalities related to the sphingolipid metabolism in the brain and kidneys of two well validated spontaneously hypertensive rat strains, the stroke-prone (SHRSP) and the stroke-resistant (SHRSR) models, as compared to the normotensive Wistar Kyoto (WKY) rat strain. Our results showed a global alteration in the metabolism of sphingolipids in both cerebral and renal tissues of both hypertensive strains as compared to the normotensive rat. However, few defects, such as reduced expression of enzymes involved in the metabolism/catabolism of sphingosine-1-phosphate and in the de novo biosynthetic pathways, were exclusively detected in the SHRSP. Although further studies are necessary to fully understand the significance of these findings, they suggest that defects in specific lipid molecules and/or their related metabolic pathways may likely contribute to the pathogenesis of hypertensive target organ damage and may eventually serve as future therapeutic targets to reduce the vascular consequences of hypertension. 相似文献
993.
994.
Osvaldo Agustín Lambri Federico Guillermo Bonifacich José Ángel García Enrique David Victor Giordano Griselda Irene Zelada Fernando Ariel Sánchez Ricardo Raúl Mocellini Fernando Plazaola 《应用聚合物科学杂志》2019,136(23):47605
Aging treatments in water and in air and controlled neutron irradiation were performed on commercial crosslinked low-density polyethylene (XLPE) for promoting different mesostructural arrangements of crystallites and crosslinking degree. Infrared spectroscopy, differential scanning calorimetry, differential thermal analysis, thermogravimetry, and dynamic mechanical analysis were used as characterization techniques. The relaxation peak related to the mobility of the grain boundaries from crystalline zones in XLPE was identified at around 260 K (at 7 Hz), involving an activation energy of 90 ± 4 kJ mol−1. The usual equation for describing the grain boundary mobility in metals involving the movement of grain boundary dislocations was adapted for studying the mobility of the boundaries among the crystalline zones, successfully. In addition, a new mechanical relaxation peak that appears at around 300 K (at 7 Hz), which involves an activation energy of 94 ± 5 kJ mol−1, was found. The driving force controlling this peak was determined as the dragging of the polymer chains at the amorphous zones adjacent to the crystals controlled by the mobility of the crystallites boundaries. The chains movement was done with break away from the physical pinning points. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 47605. 相似文献
995.
Dr. Sara Redenti Irene Marcovich Dr. Teresa De Vita Dr. Concepción Pérez Dr. Rita De Zorzi Dr. Nicola Demitri Dr. Daniel I. Perez Dr. Giovanni Bottegoni Dr. Paola Bisignano Maicol Bissaro Prof. Stefano Moro Prof. Ana Martinez Dr. Paola Storici Prof. Giampiero Spalluto Prof. Andrea Cavalli Dr. Stephanie Federico 《ChemMedChem》2019,14(3):310-314
Glycogen synthase kinase 3β (GSK-3β) and casein kinase 1δ (CK-1δ) are emerging targets for the treatment of neuroinflammatory disorders, including Parkinson's disease. An inhibitor able to target these two kinases was developed by docking-based design. Compound 12 , 3-(7-amino-5-(cyclohexylamino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-2-yl)-2-cyanoacrylamide, showed combined inhibitory activity against GSK-3β and CK-1δ [IC50(GSK-3β)=0.17 μm ; IC50(CK-1δ)=0.68 μm ]. In particular, classical ATP competition was observed against CK-1δ, and a co-crystal of compound 12 inside GSK-3β confirmed a covalent interaction between the cyanoacrylamide warhead and Cys199, which could help in the development of more potent covalent inhibitors of GSK-3β. Preliminary studies on in vitro models of Parkinson's disease revealed that compound 12 is not cytotoxic and shows neuroprotective activity. These results encourage further investigations to validate GSK-3β/CK-1δ inhibition as a possible new strategy to treat neuroinflammatory/degenerative diseases. 相似文献
996.
997.
Monte Carlo economic analysis of Baker's yeast invertase purification using two‐ and three‐phase partitioning
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998.
Bonifacich Federico Guillermo Lambri Osvaldo Agustín Mocellini Ricardo Raúl Lambri Fernando Daniel Pérez-Landazábal José Ignacio Recarte Vicente Sánchez-Alarcos Vicente García José Ángel Plazaola Fernando 《Metallurgical and Materials Transactions A》2022,53(2):706-722
Metallurgical and Materials Transactions A - The properties of technological interest of ferromagnetic shape memory alloys (FSMAs) are linked to the occurrence of a thermoelastic martensitic... 相似文献
999.
Lorenzo Solari Matteo Del Soldato Roberto Montalti Silvia Bianchini Federico Raspini Patrick Thuegaz 《International journal of remote sensing》2019,40(20):7898-7921
The 6-days repeatability of Sentinel-1 constellation allows building up an interferometric stack with unprecedented velocity. Easily updatable hot-spot analyses, frequently repeated following the update of Sentinel-1 images, represent very useful tools for MTInSAR (Multi-Temporal Interferometric Synthetic Aperture Radar) data analysis. Mountain regions are a challenging environment for interferometric analyses because of their climatic, morphological and land cover characteristics. In this context, MTInSAR data can retrieve reliable information over wide areas, with high cost-benefits ratio and where the installation of ground-based devices is not feasible. Considering the well-known limitations of interferometric techniques (such as fast motions or temporal and spatial decorrelation), hot-spot analyses are a viable solution for semi-automatic ground movements extraction over mountain regions. In this work, we present an example of a hot-spot analysis applied to a large stack of MTInSAR products generated by means of SqueeSAR technique over an alpine region (Valle d’Aosta, north-western Italy). The obtained outputs allow detecting 277 moving areas connected to landslides and mass wasting processes in general. These products are intended to be implemented in the landslide risk management chain of the region, focusing on landslide state of activity definition and landslide mapping. 相似文献
1000.