Using neural networks to select wavelet features for breast cancerdiagnosis

This study focuses on improving microcalcification classification by establishing an efficient computer-aided diagnosis system that extracts Daubechies-4 and biorthogonal wavelet features. These wavelets were chosen because they have been used in military target recognition and fingerprint recognition research with images characterized by low contrast, similar to mammography. Feature selection techniques are employed to further increase classification performance. The artificial neural network feature selection techniques are complemented by a conventional decision boundary-based feature selection method. The results using the wavelet features are compared to more conventional measures of image texture, angular second moment, and Karhunen Loeve coefficients. The use of alternative signal processing to compare wavelet and neural techniques allows for a measure of the problem difficulty. It is concluded that advances and contributions have been made with the introduction of two novel feature extraction methods for breast cancer diagnosis, wavelets and eigenmasses. Additionally, feature selection techniques are demonstrated, compared, and validated, transforming adequate discrimination power into promising classification results     

Microstructure and fracture behaviour of short and long fibre-reinforced polypropylene composites

Microstructure and fracture mechanical behaviour of injection-moulded, longer glass fibrereinforced polypropylene (Verton* aspect ratio 320) were studied as a function of fibre volume fraction and compared to that of shorter fibre-filled polypropylene (aspect ratio 70). Toughness was measured using instrumented notched lzod and falling weight impact tests, as well as compact tension specimens. It was found that the addition of longer fibres generally increased the toughness of the material, although more significant increases were seen in the impact tests than were seen in the compact tension test. For the latter results, a correlation between toughness improvement and microstructural details was performed on the basis of the microstructural efficiency concept, a semi-empirical approach of the formK _c,C = (a* +nR)K _c,M, where,K _c,C andK _c,M are the fracture toughnesses of the composite and the matrix, respectively,_a* is a matrix stress correction factor,n is a scaling parameter andR is a fibre reinforcement effectiveness factor. The latter corrects for differences in the composite microstructures, and incorporates effective fibre orientation factors, layering of injection moulded parts, and fibre volumes in the different layers.Nomenclature a crack length - a ^* matrix toughness correction factor - A cross-sectional area - B thickness of the sample plaques - C thickness of the composite core regions - E _peak energy adsorbed up to the maximum force in the impact load-displacement curve - E _t tensile modulus - F _max maximum force in impact force-displacement curves - f _p fibre orientation factor - f _pe effective orientation factor - f _pe,C effective orientation parameter, core region - f _{pe, s} effective orientation parameter, surface region - F critical load in the tensile test load-displacement curves - K _c critical stress intensity factor/fracture toughness - K _L fracture toughness of the composite materials - K _d dynamic fracture toughness - K _L fracture toughness of the matrix - L test with crack parallel to the mould filling direction - M microstructural efficiency factor - n scaling parameter for reinforcement effectiveness factor (energy absorbtion ratio) - R reinforcement effectiveness factor - S thickness of the composite surface regions - T test with crack perpendicular to the mould filling direction - V _f fibre volume fraction - V _m matrix volume fraction (= 1 —V _f) - W specimen width - W _f fibre weight fraction - W _m matrix weight fraction (= 1 —W _f) - X _n number average fibre length - X _v volume average fibre length - Y(a/ W) polynomial correction for compact tension specimens - variable in effective orientation factor formula - variable in effective orientation factor formula - _B strain to break - _c density of the composite - _f fibre density - _m matrix density - _F fracture strength - fibre angle with respect to a reference direction     

Crypt-equivalent algebraic specifications

Summary Equivalence is a fundamental notion for the semantic analysis of algebraic specifications. In this paper the notion of crypt-equivalence is introduced and studied w.r.t. two loose approaches to the semantics of an algebraic specification T: the class of all first-order models of T and the class of all term-generated models of T. Two specifications are called crypt-equivalent if for one specification there exists a predicate logic formula which implicitly defines an expansion (by new functions) of every model of that specification in such a way that the expansion (after forgetting unnecessary functions) is homologous to a model of the other specification, and if vice versa there exists another predicate logic formula with the same properties for the other specification. We speak of first-order crypt-equivalence if this holds for all first-order models, and of inductive crypt-equivalence if this holds for all term-generated models. Characterizations and structural properties of these notions are studied. In particular, it is shown that first order crypt-equivalence is equivalent to the existence of explicit definitions and that in case of positive definability two first-order crypt-equivalent specifications admit the same categories of models and homomorphisms. Similarly, two specifications which are inductively crypt-equivalent via sufficiently complete implicit definitions determine the same associated categories. Moreover, crypt-equivalence is compared with other notions of equivalence for algebraic specifications: in particular, it is shown that first-order cryptequivalence is strictly coarser than abstract semantic equivalence and that inductive crypt-equivalence is strictly finer than inductive simulation equivalence and implementation equivalence.     

Finite canonical rewriting systems for congruences generated by concurrency relations

WhenC is a concurrency relation on alphabet , then ^*/= _C is a free partially commutative monoid. Here we show that it is decidable in polynomial time whether or not there exists a finite canonical rewriting systemR on such that the congruences _R ^* generated byR and = _C induced byC coincide. Further, in case such a systemR exists, one such system can be determined in polynomial time.     

Synthesis and Pharmacological In Vitro Investigations of Novel Shikonin Derivatives with a Special Focus on Cyclopropane Bearing Derivatives

Melanoma is the deadliest form of skin cancer and accounts for about three quarters of all skin cancer deaths. Especially at an advanced stage, its treatment is challenging, and survival rates are very low. In previous studies, we showed that the constituents of the roots of Onosma paniculata as well as a synthetic derivative of the most active constituent showed promising results in metastatic melanoma cell lines. In the current study, we address the question whether we can generate further derivatives with optimized activity by synthesis. Therefore, we prepared 31, mainly novel shikonin derivatives and screened them in different melanoma cell lines (WM9, WM164, and MUG-Mel2 cells) using the XTT viability assay. We identified (R)-1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enyl 2-cyclopropyl-2-oxoacetate as a novel derivative with even higher activity. Furthermore, pharmacological investigations including the ApoToxGlo^TM Triplex assay, LDH assay, and cell cycle measurements revealed that this compound induced apoptosis and reduced cells in the G1 phase accompanied by an increase of cells in the G2/M phase. Moreover, it showed hardly any effects on the cell membrane integrity. However, it also exhibited cytotoxicity against non-tumorigenic cells. Nevertheless, in summary, we could show that shikonin derivatives might be promising drug leads in the treatment of melanoma.     

Etude electrochimique de differentes ilmenites

The electrochemical behaviour of several natural ilmenites has been studied by cyclic voltammetry. From the analysis of the current-voltage curves it was concluded that the valences of the metal ions in FeTiO₃ are Fe^II and Ti^IV. It was also found that little amounts of Fe^III and excess of Ti^IV (probably TiO₂) can enter into the composition of the ilmenites.     

On Modulus and Fracture Toughness of Rigid Particulate Filled High Density Polyethylene

A Kaolin-filled, high-density polyethylene (HDPE) system was used to illustrate the influence of particulates on modulus and toughness of the bulk material. A variation of filler content, particulate size and coupling quality for two HDPE-matrix systems with different viscosity led to a strong dependency of elastic modulus and fracture toughness under various testing conditions, e.g. static loading, fatigue and impact.

A stiffness improvement with increasing filler content was achieved by all coupling qualities. The developed Kaolin reinforcement of HDPE with optimised coupling offers an improvement of the stiffness and toughness under all investigated loading conditions. The degree of improvement depends on the particulate size and matrix viscosity. The energy dissipation mechanisms were investigated by fractographic analysis.     

Effect of moisture and particle size on the extractability of oils from seeds with supercritical CO2

Moisture level and particle size of soybeans, peanuts and cottonseed were correlated with the extraction rate and yield of oil when extracted with supercritical carbon dioxide (SC-CO₂) at a constant temperature (50 C) and pressure (8000 psig). The rate of extraction and ultimate oil yields were quite low with cracked soybeans. However, good extraction rates and nearly theoretical oil yields were obtained from ground or thinly flaked (<0.010″) seeds. Moisture levels between 3% and 12% had little effect on extracability. Oil composition was not influenced by either parameter. Scanning electron microscopy was used to study seed structure before and after extraction with SC-CO₂. Micrographs of SC-CO₂-extracted seeds were similar to hexane-extracted seeds. Presented at the AOCS Meeting, May 1983, Chicago.     

Potential synthetic lubricants: Diol ester of C18-saturated cyclic acids

Monoalkyl esters of linseed-oil-derived C₁₈-saturated cyclic acids (HCal), described in earlier work, showed promise as lubricant base stocks for turbine aircraft as set forth in the military specification MIL-L-7808E. These esters, however, did not exhibit the increased oxidative stability and higher viscosity required by the more recent specification MIL-L-23699. Six diol esters of HCal have now been prepared. Both hindered and unhindered dihydric alcohols were used, including ethylene glycol, 1,4-cyclohexanedimethanol, 1,4-benzenedimethanol, 2,3-dimethyl-1,3-propanediol and 2,2,4,4-tetramethyl-1,3-cyclobutanediol (I). The viscosities of these esters at 210F ranged from 10.1 to 19.6 centistokes and the pour points, from −35 to −62F. Oxidative stabilities at 400F were determined with 0.5% each of phenyl-a-napthylamine (PANA) andp,p’-dioctyldiphenylamine as inhibitors. The esters of the unhindered diols had poor stability, whereas esters of the hindered diols, in particular I, exhibited excellent resistance to the formation of acidic decomposition products and sludge. Although the HCal ester of I by itself is too viscous to meet specification MIL-L-23699, its ASTM slope (0.650) is excellent. Blends of this material with less viscous hindered esters, commercially available, may find application as lubricants for high-performance turbine engines used in various aircraft. Presented at the AOCS Meeting in Los Angeles, 1966. No. Utiliz. Res. Dev. Div., ARS, USDA.