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排序方式: 共有100条查询结果,搜索用时 156 毫秒
11.
JC Barbato LG Koch A Darvish GT Cicila PJ Metting SL Britton 《Canadian Metallurgical Quarterly》1998,85(2):530-536
Mice homozygous for a disruption in the Mdr2 gene (Mdr2 (-/-) mice) lack the Mdr2 P-glycoprotein (P-gp) in the canalicular membrane of the hepatocyte and are unable to excrete phosphatidylcholine into the bile. These mice develop a nonsuppurative cholestatic liver disease, presumably caused by the high concentrations of free cytotoxic bile acids in bile. We generated transgenic mice that express the human homolog of Mdr2, MDR3, specifically in the liver by the use of an albumin promoter. In these mice the MDR3 P-gp is exclusively located in the canalicular membrane of hepatocytes and phospholipid excretion into bile is restored. Mice that contain the same amount of MDR3 P-gp as that of Mdr2 P-gp in wild-type mice, also excrete the same amount of phospholipids. No histopathological abnormalities were observed in the livers of these mice. In mice that express MDR3 at a higher or lower level, the phospholipid excretion correlated with the amount of MDR3 P-gp. We conclude that the human MDR3 P-gp is functionally homologous to the murine Mdr2 P-gp and that it can fully replace this P-gp in Mdr2 (-/-) mice, restoring the excretion of phospholipids into the bile. The phospholipid excretion is limited by the amount of MDR3 or Mdr2 P-gp. The excretion of cholesterol is not tightly coupled to the excretion of phospholipids in these mice, because a very low phospholipid excretion level is sufficient to give almost wild-type cholesterol excretion into the bile. 相似文献
12.
Hassan Hassanzadeh Mehran Pooladi‐Darvish David W. Keith 《American Institute of Chemical Engineers》2009,55(2):475-485
Carbon dioxide injection into deep saline aquifers is an important option for managing CO2 emissions. Injected CO2 dissolves into formation brines from above, increasing brine density and creating an unstable hydrodynamic state favorable for natural convection. Long‐term buoyancy‐driven flow of high‐density CO2‐saturated brine leads to faster trapping through improved dissolution and can reduce the risk of CO2 leakage from storage sites. We investigate the role of natural flow of aquifers and associated dispersion on the onset of convection. A linear stability analysis of a transient concentration field in a laterally infinite, horizontal, and saturated porous layer with steady horizontal flow is presented. The layer is subjected to a sudden rise in CO2 concentration from the top and is closed from the bottom. Solution of the stability equations is obtained using a Galerkin technique and the resulting equations are integrated numerically. We found simple scaling relationships that follow tDc~60(1 + PeT)Ra‐2 for the onset time of convection and a~0.05Ra/(1 + PeT) for the wavenumber of the initial instabilities. Results reveal that transverse dispersion increases the time to onset of convection for the entire range of Ra. Furthermore, transverse dispersion decreases the critical wavenumber of the instabilities. These results facilitate screening candidate sites for geological CO2 storage. © 2008 American Institute of Chemical Engineers AIChE J, 2009 相似文献
13.
Hashemian Mina Razzazi Farbod Zarrabi Houman Moin Mohammad Shahram 《Telecommunication Systems》2019,72(1):69-79
Telecommunication Systems - Along with the widespread use of smartphones, activity recognition using embedded inertial sensors has intrigued researchers. The learning and employing activity... 相似文献
14.
Jabbarpour Mohammad Reza Marefat Alireza Jalooli Ali Zarrabi Houman 《Wireless Networks》2019,25(1):335-354
Wireless Networks - In recent times, vehicular network research has attracted the attention of both researchers and the industry partly due to its potential applications in efficient traffic... 相似文献
15.
Houman Darvish Pejman Ghani Mohsen Zare Hesam Rezaei 《Petroleum Science and Technology》2018,36(5):338-342
The significant number of oil reservoir are bitumen and heavy oil. One of the approaches to enhance oil recovery of these types of reservoir is dilution of reservoir oil by injection of a solvent such as tetradecane into the reservoirs to modify viscosity and density of reservoir fluids. In this investigation, an effective and robust estimating algorithm based on fuzzy c-means (FCM) algorithm was developed to predict density of mixtures of Athabasca bitumen and heavy n-alkane as function of temperature, pressure and weight percent of the solvent. The model outputs were compared to experimental data from literature in different conditions. The coefficients of determination for training and testing datasets are 0.9989 and 0.9988. The comparisons showed that the proposed model can be an applicable tool for predicting density of mixtures of bitumen and heavy n-alkane. 相似文献
16.
Mohammad Hosein Emami Baghdadi Houman Darvish Hosein Zanbouri Karim Rouhibakhsh 《Petroleum Science and Technology》2018,36(11):787-792
Recently the studies expressed that the noticeable number of oil reservoirs in all over the world are heavy oil and bitumen reservoirs. So the importance of enhancement of oil recovery (EOR) processes for heavy oil and bitumen reservoirs is highlighted. The Dilution of the reservoir fluid by solvents such as tetradecane is one of well-known methods for these types of reservoirs which effects oil recovery by decreasing viscosity. In the present study, Fuzzy c-means (FCM) algorithm was coupled with Adaptive neuro-fuzzy inference system (ANFIS) to predict viscosity of bitumen and tetradecane in terms of temperature, pressure and weight percent of tetradecane. The coefficients of determination for training and testing steps were calculated such as 0.9914 and 0.9613. The comparison of results and experimental data expressed that FCM-ANFIS algorithm has great potential for estimation of viscosity of bitumen and tetradecane. 相似文献
17.
Houman Alipooramirabad Anna Paradowska Olivier Lavigne Reza Ghomashchi Mark Reid 《Science & Technology of Welding & Joining》2017,22(6):484-495
Neutron diffraction (ND) is commonly used to investigate the stress redistribution before and after post-weld heat treatment (PWHT) in welded structures. However, there is a lack of information on the evaluations of strains during PWHT. The present work employed in situ ND to measure the relaxation of residual strains during conventional PWHT in multi-pass high-strength low-alloy steel welds. It was found that strain relaxation occurs principally during the heating stage of the heat treatment. The findings have important economic bearings and can be used to characterise comparable material combinations and optimise the PWHT process for high-strength low-alloy weld joints. This unique information also provides a valuable benchmark for the finite element modelling of this complex process. 相似文献
18.
Houman Savoji Dipak Rana Takeshi Matsuura Mohammad Soltanieh Shahram Tabe 《应用聚合物科学杂志》2012,124(3):2300-2310
Integrally skinned asymmetric membranes for the separation of O2 and N2 were fabricated by the phase inversion technique from polysulfone, polyetherimide, and polyimide. Two types of surface modifying macromolecules (SMMs) including hydrophilic SMM (LSMM) and charged SMM (cSMM) were synthesized and blended with the casting solution to modify the membrane surface. The cast film was then immersed in the first coagulant alcohol (methanol, ethanol, or isopropanol) for a predetermined period, before being immersed in the second coagulant (water). The SMMs used in these experiments were laboratory synthesized by the two‐step process of polyurethane prepolymer synthesis and end capping, before being characterized by differential scanning calorimetry. Their molecular structure was determined from the molecular weight obtained by gel permeation chromatography. The membranes were characterized by contact angle measurement and O2 and N2 gas permeation performance. Attempts were made to interpret the gas permeation data by delayed demixing affected by solubility parameters of polymer, solvent, and nonsolvent. Furthermore, the permeation performance of cSMM membranes was interpreted by the solvation of the charged sulfonate groups present in cSMM. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012 相似文献
19.
从MATLAB到嵌入式C代码的实现 总被引:1,自引:0,他引:1
Houman Zarrinkoub 《电子设计应用》2008,(10)
从设想到硬件实现的鸿沟令从事嵌入式开发的工程师们深感头疼,把MATLAB指令自动翻译成C代码将令他们感到鼓舞。本刊将于十、十一月连载两篇系列技术文章介绍如何实施这个技术,本月文章是第一部分。主要介绍如何从MATLAB命令行直接生成有效的嵌入式C代码。第二部分文章将讨论如何将嵌入式MATLAB代码整合到Simulink模块中,使算成为基于模型设计流程中的一部分。 相似文献
20.
Multidimensional Systems and Signal Processing - The most prominent issue relevant to the initiative multi-level inverters is how to provide a high-step staircase quasi-sinusoidal voltage against... 相似文献