Modus Operandi of Simultaneous Covering Synthesis from Precursor Heterogeneity for Shelled Nanorods for Multipotent Cancer Theranostics

The synthesis of nanostructures using homogeneous precursors in the solution phase is widely used to achieve uniformity and well‐defined morphological control. However, drawbacks such as the lack of diversity due to the limited reaction rate modulation exist. One‐step, core–shell nanorod formation using simultaneous covering synthesis using solid and ionic heterogeneous precursors is proposed in this study. A Te‐Bi₂Te₃/TeO₂ core–shell structure is successfully synthesized by precisely controlling various influencing factors, including concentration, temperature, and pH, and its physicochemical and photochemical properties are thoroughly investigated. The proposed nanostructure overcomes the oxidation susceptibility of Te and can be applied to multipotent cancer theranostics in vitro and in vivo in combination with computed tomography imaging.     

有铝激光器和无铝激光器特征温度对比研究

为了测量两种有源区材料半导体激光器的温度灵敏度,文中对InGaAsP/GaAs无铝和AlGaInAs/AlGaAs/GaAs有铝的808 nm大功率半导体激光器,采用阈值电流法衡量两种有源区材料激光器的特征温度。在各种温度下实验性地测量激光器的P-I曲线,并采用线性拟合法得到阈值温度线性关系,实验结果表明有铝激光器温度性能明显优于无铝激光器。     

Selective Photothermal Tumor Therapy Using Nanodiamond‐Based Nanoclusters with Folic Acid

This paper describes the fabrication and evaluation of folic acid (FA)‐conjugated nanodiamond (ND) nanoclusters for selective photothermal tumor therapy. ND nanoclusters with surface carboxyl groups are aminated using ethylenediamine and conjugated with FA via carbodiimide chemistry. The temperature of an aqueous ND dispersion (10 μg mL^?1) is increased to 54 °C upon laser exposure for 5 min. FA‐ND nanoclusters are preferentially taken up by KB cells (folate receptor positive) compared to WI‐38 (folate receptor negative) cells, suggesting specificity for tumor cells that overexpress folate receptors. Cell viability tests reveal that FA‐ND nanoclusters effectively and selectively ablate KB cells upon near‐infrared (NIR) laser exposure. In addition, fluorescence microscopy images confirm that only KB cells treated with FA‐ND nanoclusters are ablated in a spot (200 μm in diameter) by NIR laser exposure. In an animal model, a large amount of FA‐ND nanoclusters is accumulated into tumor tissue, resulting in dramatically reduced tumor volume post‐NIR laser exposure as compared to ND nanoclusters.     

Synchronous Growth of High‐Quality Bilayer Bernal Graphene: From Hexagonal Single‐Crystal Domains to Wafer‐Scale Homogeneous Films

The precise control of the domain structure, layer thickness, and stacking order of graphene has attracted intense interest because of its great potential for nanoelectronics applications. Much effort has been devoted to synthesize semiconducting Bernal (AB)‐stacked bilayer graphene because of its tunable band structure and electronic properties that are unavailable to single‐layer graphene. However, fast growth of large‐scale bilayer graphene sheets with a high AB‐stacking ratio and high mobility on copper poses a tremendous challenge, which has to overcome the self‐limiting effect. This study reports a low‐cost but facile method to rapidly synthesize bilayer Bernal graphene by atmospheric pressure chemical vapor deposition using polystyrene as the feedstock. The bilayer graphene grains and continuous film obtained are of high quality and exhibit field‐effect hole mobilities as high as 5700 and 2200 cm² V^?1 s^?1 at room temperature, respectively. In addition, a synchronous growth mechanism of bilayer graphene is revealed by monitoring the growth process, resulting in a high surface coverage of nearly 100% for a near‐perfect AB‐stacking order. This new synthesis route is significant for industrial application of bilayer graphene and investigation of the growth mechanism of graphene by the chemical vapor deposition process.     

Formation Theory and Printability of Photocurable Hydrogel for 3D Bioprinting

Bio-ink has gradually transited from ionic-crosslinking to photocrosslinking due to photocurable bio-hydrogel having good formability and biocompatibility. It is very important to understand and quantify the crosslinking process of photocurable hydrogels, otherwise, bioprinting cannot be standardized and scalable. However, there are few studies on hydrogel formation process and its photocrosslinking behavior which cannot be accurately predicted. Herein, the photoinitiated radical polymerized bio-hydrogels are taken as an example to establish the formation theory. Three typical crosslinking reactions are first distinguished. It is further proposed that not all double-bonds consumed during crosslinking contributeequally to polymerization. Then the concept of effective double-bond conversion (EDBC) is elicited. Deriving from EDBC, several important formation indices are defined. According to theory, it is predicted that slow crosslinking can improve the crosslinking degree. Furthermore, based on the slow crosslinking effect, a new strategy of projection-based 3D printing (PBP) is proposed, which significantly improved printing quality and efficiency. Overall, this work will fill the gap in hydrogel's formation theory, making it possible to accurately quantify the formation process.     

Analysis of issues in gate recess etching in the InAlAs/InGaAs HEMT manufacturing process

We have developed an InAlAs/InGaAs metamorphic high electron mobility transistor device fabrication process where the gate length can be tuned within the range of 0.13 μm–0.16 μm to suit the intended application. The core processes are a two-step electron-beam lithography process using a three-layer resist and gate recess etching process using citric acid. An electron-beam lithography process was developed to fabricate a T-shaped gate electrode with a fine gate foot and a relatively large gate head. This was realized through the use of three-layered resist and two-step electron beam exposure and development. Citric acid-based gate recess etching is a wet etching, so it is very important to secure etching uniformity and process reproducibility. The device layout was designed by considering the electrochemical reaction involved in recess etching, and a reproducible gate recess etching process was developed by finding optimized etching conditions. Using the developed gate electrode process technology, we were able to successfully manufacture various monolithic microwave integrated circuits, including low noise amplifiers that can be used in the 28 GHz to 94 GHz frequency range.     

140 GHz, TE22,6模式回旋振荡管高频谐振腔

通过数值计算方法,编程模拟了140 GHz, TE22,6模式回旋振荡管开放式缓变截面谐振腔的传播特性,计算出谐振腔的谐振频率和品质因数;利用CST软件对该高频谐振腔进行仿真计算,得到腔体内横截面的电场分布云图。通过实验和仿真软件得到的数据进行比较,两者有较好的一致性。测试结果表明,当磁场为5.48 T,电子注电流为28 A,电子注电压为68.6 kV时,TE22,6模式的平均输出功率为0.25 kW,峰值功率为0.56 MW。当磁场为5.68 T,电子注电流为27.6 A,电子注电压为69.12 kV时,回旋振荡管可同样工作于TE22,6,2模式,平均输出功率为0.21 kW,峰值功率为0.47 MW。     

改进CDIO下"电气控制与PLC技术"教学研究

针对当前"电气控制与PLC技术"课程教学存在的课内外脱节、师生进度状态分离的问题,本文利用"雨课堂"微信公众号平台引入线上即时讨论、知识测评和进度反馈机制、教师主动接收反馈信息、及时动态调整教学、并将其融入到CDIO,形成动态反馈调整的改进型CDIO模式.以新兴智造专业群学生进行教学实施,结果表明该模式加强了课内课外学习的连接,增强了师生进度的协调,提高了学生学习主动性,教学效果良好.     

低于1×10-6/℃的低压CMOS带隙基准电流源

提出了一种新颖的CMOS带隙基准电流源的二阶曲率补偿技术,通过增加一个运算跨导放大器(OTA),使带隙基准参考电路的电流特性与理论分析相符合,实现低温度系数(TC)的参考电流。该电路采用SMIC0.13μm标准CMOS工艺,可在1.2 V的电源电压下工作,有效面积为0.045 mm2。仿真结果表明,在-40～85℃温度范围内参考电流的温度系数为0.5×10-6/℃;当电源电压为1.1 V时,电路依然可以正常工作,电源电压调整率为1 mV/V。     

Streaming Media and Multimedia Conferencing Traffic Analysis Using Payload Examination

This paper presents a method and architecture to analyze streaming media and multimedia conferencing traffic. Our method is based on detecting the transport protocol and port numbers that are dynamically assigned during the setup between communicating parties. We then apply such information to analyze traffic generated by the most popular streaming media and multimedia conferencing applications, namely, Windows Media, Real Networks, QuickTime, SIP and H.323. We also describe a prototype implementation of a traffic monitoring and analysis system that uses our method and architecture.