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71.
72.
Ludmila Ilhnkov 《Journal of the Institute of Brewing》1985,91(4):238-241
Three non-linked loci were found to be involved in thiamine excretion in Saccharomyces cerevisiae, i.e. thi2 which is complementary with thi3 and thi4, the latter two being substitutable mutually but acting also together. Mutation thi3 was present already in strain Nα, which produced relatively high frequencies of excreters after UV treatment. Non-excreting ‘revertants’ of unstable excreters derived from another haploid strain contained recessive mutation thi2, so that mutation thi3 can be substituted also by the metabolic or physiological disorders ruling after UV treatment. Mutations thi2 were found also in all 43 analysed stable excreting mutants obtained by UV treatment of strain Nα which indicates that they are either inevitable for the excretion or are specifically selected by the selection method used. At least one suppressor locus of thiamine excretion was present in that strain of S. cerevisiae, which did not produce thiamine excreters after UV treatment in spite of its ability to synthetise thiamine. 相似文献
73.
We propose a probabilistic framework for classifier combination, which gives rigorous optimality conditions (minimum classification error) for four combination methods: majority vote, weighted majority vote, recall combiner and the naive Bayes combiner. The framework is based on two assumptions: class-conditional independence of the classifier outputs and an assumption about the individual accuracies. The four combiners are derived subsequently from one another, by progressively relaxing and then eliminating the second assumption. In parallel, the number of the trainable parameters increases from one combiner to the next. Simulation studies reveal that if the parameter estimates are accurate and the first assumption is satisfied, the order of preference of the combiners is: naive Bayes, recall, weighted majority and majority. By inducing label noise, we expose a caveat coming from the stability-plasticity dilemma. Experimental results with 73 benchmark data sets reveal that there is no definitive best combiner among the four candidates, giving a slight preference to naive Bayes. This combiner was better for problems with a large number of fairly balanced classes while weighted majority vote was better for problems with a small number of unbalanced classes. 相似文献
74.
ABSTRACTThe corrosivity of atmosphere in the continental territory of Russia toward carbon steel, zinc, copper and aluminium was determined and estimated. The atmosphere corrosivity was determined from experimental data on first-year corrosion losses in representative test locations. The atmosphere corrosivity was estimated using first-year corrosion losses of structural materials calculated by means of dose–response functions: new ones (DRFN) and those presented in ISO 9223 (DRFS). Estimation of atmosphere corrosivity in the Russian Federation (RF) territory was performed using the data bank of the Institute of physical chemistry and electrochemistry of the Russian Academy of Sciences containing long-term annual average meteorological atmosphere parameters. The mapping of RF continental territory by categories of atmosphere corrosivity is presented. The atmosphere corrosivities estimated by DRFN and DRFS for each metal are compared. It has been shown that DRFN provides more reliable atmosphere corrosivity estimates. 相似文献
75.
Siarhei A. Dabravolski Nikita G. Nikiforov Ali H. Eid Ludmila V. Nedosugova Antonina V. Starodubova Tatyana V. Popkova Evgeny E. Bezsonov Alexander N. Orekhov 《International journal of molecular sciences》2021,22(8)
Polycystic ovarian syndrome (PCOS) is the most common endocrine–metabolic disorder affecting a vast population worldwide; it is linked with anovulation, mitochondrial dysfunctions and hormonal disbalance. Mutations in mtDNA have been identified in PCOS patients and likely play an important role in PCOS aetiology and pathogenesis; however, their causative role in PCOS development requires further investigation. As a low-grade chronic inflammation disease, PCOS patients have permanently elevated levels of inflammatory markers (TNF-α, CRP, IL-6, IL-8, IL-18). In this review, we summarise recent data regarding the role of mtDNA mutations and mitochondrial malfunctions in PCOS pathogenesis. Furthermore, we discuss recent papers dedicated to the identification of novel biomarkers for early PCOS diagnosis. Finally, traditional and new mitochondria-targeted treatments are discussed. This review intends to emphasise the key role of oxidative stress and chronic inflammation in PCOS pathogenesis; however, the exact molecular mechanism is mostly unknown and requires further investigation. 相似文献
76.
Alexandra Pulyalina Galina Polotskaya Mikhail Goikhman Irina Podeshvo Ludmila Kalyuzhnaya Mikhail Chislov Alexander Toikka 《应用聚合物科学杂志》2013,130(6):4024-4031
Poly(benz‐3,1‐oxazinone‐4) was prepared by thermal cyclization of its hydrolytically stable precursor polyamic acid. Both polymer and its precursor were investigated as membrane materials. Thermogravimetric analysis and contact angle measurements were carried out for characterization of peculiarity of membrane compositions and analysis of membrane surface. Pervaporation of water–isopropanol mixture was studied in the wide range of feed composition. To interpret the pervaporation transport properties of the membranes, swelling experiments were performed, kinetic curves of sorption and desorption were plotted, and basic sorption and diffusion parameters were analyzed. It was established that poly(benz‐3,1‐oxazinone‐4) membrane is extremely effective in dehydration of water–isopropanol mixture and shows high separation factor. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 4024–4031, 2013 相似文献
77.
Mikhail A. Matsko Ludmila G. Echevskaya Marina P. Vanina Marina I. Nikolaeva Tatyana B. Mikenas Vladimir A. Zakharov 《应用聚合物科学杂志》2012,126(6):2017-2023
Separation into narrow MWD fractions (liquid–liquid fractionation) and preparative TREF (temperature rising elution fractionation) with subsequent analysis of fractions by GPC, FTIR, and 13C NMR spectroscopy were used to study the comonomer distribution of ethylene/1–hexene copolymers produced over highly active supported titanium‐ and vanadium‐magnesium catalysts (TMC and VMC) and a supported zirconocene catalyst. These catalysts produce PE with different MWD: Mw/Mn values vary from 2.9 for zirconocene catalyst, 4.0 for TMC, and 15 for VMC. 1‐Hexene increases polydispersity to 25 for copolymer produced over VMC and hardly affects MWD of the copolymer produced over TMC and zirconocene catalysts. The most broad short chain branching distribution (SCBD) was found for ethylene/1–hexene copolymers produced over TMC. VMC and supported zirconocene catalyst produce copolymers with uniform profile of SCB content vs. molecular weight in spite of great differences in Mw/Mn values (22 and 2.5 respectively). TREF data showed that majority of copolymer produced over supported zirconocene catalyst was eluted at 70–90°C (about 85 wt %). In the case of VMC copolymer's fractions were eluted in the broad temperature interval (40–100°C). Accordingly, TREF data indicate a more homogeneous SCBD in copolymer, produced over supported zirconocene catalyst. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012 相似文献
78.
The distribution of gas and liquid among four parallel pipes was studied with and without orifice restrictions. The results show that the two phases may not be equally distributed among the pipes. It is shown that the two-phase flow mixture can “choose” to flow in one, two, three or in all four pipes depending on gas and liquid flow rates, on pipe inclination and on the orifice plate size. Addition of orifice plates expands the region of stability and the range of flow in all four pipes. The experimental results are in reasonable agreement with the analysis. 相似文献
79.
Peter N. Kuznetsov Jan Bimer Piotr D. Salbut Evgeny D. Korniyets Ludmila I. Kuznetsova Colin E. Snape 《Fuel Processing Technology》1997,50(2-3):139-152
Kansk-Achinsk brown coal hydrogenation and swelling in tetralin, in low molecular alcohols, in other solvents and in binary mixtures were studied. Tetralin was found to be the most effective liquefaction solvent, but methanol and ethanol were the active ones in coal swelling. Synergistic effects were observed when the mixtures of tetralin and methanol or ethanol were used for liquefaction and swelling. The effect of binary solvents was shown to be due to the ability of alcohol components to cause brown coal to swell improving the availability of the fragments of coal matter for the reactive hydrogen donor tetralin molecules. 相似文献
80.
Marina I. Nikolaeva Mikhail A. Matsko Tatiana B. Mikenas Ludmila G. Echevskaya Vladimir A. Zakharov 《应用聚合物科学杂志》2012,125(3):2042-2049
The data on the effect of comonomer (propylene and 1-hexene) on molecular weight (Mw), molecular weight distribution (MWD), and content of terminal double bonds were obtained for ethylene/α-olefin copolymers produced over a supported titanium–magnesium catalyst (TMC) upon polymerization in the absence of hydrogen. The experimental data on the effect of comonomer concentration on Mw of polymers were used to calculate the ratios between the effective rate constants of chain transfer with monomer and the propagation rate constant. It was shown that the effective rate constant of chain transfer with monomers increases in the row of monomers: ethylene < 1-hexene < propylene. Meanwhile, the data on the effect of copolymers on content of terminal double bonds of various types demonstrate that different reactions of chain transfer with comonomer may simultaneously occur during copolymerization. It results in simultaneous formation of terminal vinylidene and trans-vinylene bonds. Therefore, the calculated rate constants of chain transfer with comonomer are complex values, which include the rate constants of chain transfer with comonomer occurring via different mechanisms. The data on MWD, short chain branching (SCB) and terminal double bonds content of different types were obtained by molecular weight fractionation of copolymers followed by the analysis of narrow fractions. The analysis of the data on MWDs of SCB and terminal double bonds shows that active sites of the TMC are considerably heterogeneous with respect to the rates of different chain transfer reactions with monomers. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012 相似文献