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排序方式: 共有422条查询结果,搜索用时 13 毫秒
71.
Valentina Vozella Bryan Cruz Luis A. Natividad Federica Benvenuti Nazzareno Cannella Scott Edwards Eric P. Zorrilla Roberto Ciccocioppo Marisa Roberto 《International journal of molecular sciences》2021,22(6)
Marchigian Sardinian alcohol-preferring (msP) rats serve as a unique model of heightened alcohol preference and anxiety disorders. Their innate enhanced stress and poor stress-coping strategies are driven by a genetic polymorphism of the corticotropin-releasing factor receptor 1 (CRF1) in brain areas involved in glucocorticoid signaling. The activation of glucocorticoid receptors (GRs) regulates the stress response, making GRs a candidate target to treat stress and anxiety. Here, we examined whether mifepristone, a GR antagonist known to reduce alcohol drinking in dependent rats, decreases innate symptoms of anxiety in msPs. Male and female msPs were compared to non-selected Wistar counterparts across three separate behavioral tests. We assessed anxiety-like behavior via the novelty-induced hypophagia (NIH) assay. Since sleep disturbances and hyperarousal are common features of stress-related disorders, we measured sleeping patterns using the comprehensive lab monitoring system (CLAMS) and stress sensitivity using acoustic startle measures. Rats received an acute administration of vehicle or mifepristone (60 mg/kg) 90 min prior to testing on NIH, acoustic startle response, and CLAMS. Our results revealed that both male and female msPs display greater anxiety-like behaviors as well as enhanced acoustic startle responses compared to Wistar counterparts. Male msPs also displayed reduced sleeping bout duration versus Wistars, and female msPs displayed greater acoustic startle responses versus male msPs. Importantly, the enhanced anxiety-like behavior and startle responses were not reduced by mifepristone. Together, these findings suggest that increased expression of stress-related behaviors in msPs are not solely mediated by acute activation of GRs. 相似文献
72.
Larissa Braga Bueno-Borges Grasiela Cristina Pereira dos Santos Severino Matias de Alencar Marisa Aparecida Bismara Regitano-d'Arce 《Journal of the American Oil Chemists' Society》2019,96(12):1379-1388
Waste cooking oils (WCO) can be used as feedstock for biodiesel (fatty acid ethyl or methyl esters—FAEE or FAME) production. Their usual high acidity, high moisture, and low stability can impair the reaction yield and generate a low-quality biodiesel. Here, we performed liquid–liquid washings using WCO and ethanol-based solvents with the goal of generating oil-rich miscella as FAEE feedstocks with a higher quality than WCO. Three different solvents were evaluated: 99% ethanol, 95% ethanol, and the soybean oil extraction ethanolic phase (SEP), a by-product with immense unexplored antioxidant potential obtained by extracting soybean oil using ethanol. Washings were performed in a 1000 mL flat-bottom flask at 78.1 °C, using a 1:2 (w/v) oil/solvent ratio, under magnetic stirring (1200 rpm) for 10 min. Ethyl esters were prepared via homogeneous alkali transesterification using WCO and oil-rich miscella as feedstocks. Treatments reduced the acid value by 40–61% and the peroxide value by 15–50%. Improvements in feedstock quality generated 24–54% higher biodiesel yields. The oil-rich phase produced with SEP was 15% more resistant to oxidation than WCO. This was attributed to the transference of isoflavones from the SEP. However, biodiesel from treated samples presented equal or lower oxidative stability than FAEE from WCO. High-performance liquid chromatography (HPLC) analysis showed that no isoflavones remained in biodiesel after purification. Pretreatment of WCO with ethanol-based extracts such as the SEP has great potential to improve WCO quality for biodiesel production as it can be a source of plant-based antioxidants. 相似文献
73.
Two experiments investigated the effect of positive endorsement on perceivers' impressions of young and old female targets. In Experiment 1, 160 young adult perceivers listened to a tape of a young or old forgetful target being interviewed for a volunteer job. They read a nonelaborative or elaborative reference letter for the target either before or after listening to the tape. Perceivers who read the elaborative letter after listening to the tape rated themselves as more likely to assign tasks to both young and old targets and had a higher general capability opinion of old targets. In Experiment 2, 84 older adult perceivers read an elaborative letter and listened to one of the same taped interviews. Reading the letter after the tape resulted in higher task ratings than reading it before the tape, but letter order had no effect on general capability ratings. Results are discussed in terms of impression management. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
74.
To reexamine the role of covert attention in visual search, the authors directly manipulated attention by peripherally cueing the target location and analyzed its effects on the set-size and the eccentricity effects. Observers participated in feature and conjunction tasks. Experiment 1 used precues, and Experiment 2 used postcues in a yes–no task under valid-, invalid-, and neutral-cueing conditions. Experiments 3 and 4 used a 2-interval alternative forced-choice visual-search task under cued and neutral conditions. Precueing the target location improved performance in feature and conjunction searches; postcueing did not. For the cued targets, the eccentricity effect for features and conjunctions was diminished, suggesting that the attentional mechanism improves the quality of the sensory representation of the attended location. The conjunction set-size effect was reduced but not eliminated. This questions serial-search models that attribute a major role to covert attention in visual search. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
75.
A model to analyze the behavior of reinforced concrete tension ties strengthened with fiber reinforced plastic (FRP) laminates is developed that allows introduction of a nonlinear constitutive relationship for materials and bond-slip laws at the steel and FRP interface. Experimental results are introduced and compared with analytical results confirming the model reliability. By using the model, a numerical study is carried out to provide evidence of the influence of the amount of fibers and the tension-stiffening behavior of strengthened elements. Considering elements with the same mechanical percentage of reinforcement but composed of different amounts of steel and fibers, the stiffness is influenced only after steel yielding, even if the crack width is reduced by the external strengthening. Finally, evidence is provided for the reduction of tension stiffening in strengthened elements due to reduction of crack spacing. 相似文献
76.
Laise Maia Lopes Mariana Agostini de Moraes Marisa Masumi Beppu 《Journal of Polymer Research》2018,25(9):198
Silk fibroin (SF) and sodium alginate (SA) are natural polymers with many applications as biomaterials. It is possible to make blends with them in order to improve their properties. Those blends are partially miscible; therefore, understanding the mechanism and phase equilibrium of this system is important to better understand the interaction between these natural polymers. This work analyzed the mechanism of phase separation of SF and SA blends with different composition in solution and in the solid state (as membranes) using small angle light scattering with a He-Ne laser. Polymer interaction and conformation were investigated by Fourier-Transform Infrared Spectroscopy with Attenuated Total Reflectance (FTIR-ATR) and X-Ray Diffraction (XRD), and membrane morphology was analyzed by Scanning Electron Microscopy (SEM). SEM images showed interpenetrated globules in the matrix. Light scattering profile for blends in solution and in the solid state showed a peak of intensity suggesting that phase separation occurs by spinodal decomposition. 相似文献
77.
Mara L. Polo Marisa E. Spontón Franklin Jaramillo Diana A. Estenoz Gregorio R. Meira 《应用聚合物科学杂志》2018,135(4)
This work investigates the two‐step polymerization between methylene diphenyl diisocyanate (MDI), two different poly(tetramethylene oxide) macrodiols, and 1,4‐butanediol (BD) as chain extender. At the end of the prepolymerization, the reaction mixture contains MDI in excess and a prepolymer with isocyanate end group. Then, BD and a solvent (tetrahydrofuran) were added to start the finishing stage under nominal stoichiometric equilibrium. The reaction was analyzed by Fourier transform infrared spectroscopy, hydrogen nuclear magnetic resonance (1H‐NMR), and size exclusion chromatography. 1H‐NMR was employed to follow global concentrations of unreacted isocyanate end groups and internal urethane groups. This information enabled to estimate the following “effective” rate constants: k1 = 1.07 × 10?3 L mol?1 s?1 for the prepolymerization; and k2 = 1.94 × 10?4 L mol?1 s?1 for the finishing stage. These values are subject to errors caused by biases introduced in the recipe, in the measurements, in the reaction conditions, in the quality of reagents, and in the reaction mechanism assumptions. Such errors also explain the dispersion of the published rate constants values. The 1H‐NMR measurements also enabled to estimate the evolution (with extent of reaction) of the number‐average number of structural units along the prepolymerization and finishing stages; and such estimates reasonably verify Flory's classical expressions. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135, 45747. 相似文献
78.
Gabriela Hädrich Samantha Oliveira Monteiro Marisa Raquel Rodrigues Vânia Rodrigues de Lima Jean-Luc Putaux Juliana Bidone 《Drug development and industrial pharmacy》2016,42(7):1165-1173
The flavonoid quercetin (QU) is a naturally occurring compound with several biological activities. However, the oral bioavailability of this compound is very low due to the high pre-systemic metabolism in the colon and liver and its low water solubility. In this context, the development of QU-loaded nanocarriers (NEs) is a promising approach to improve the drug oral bioavailability. This study investigates the variation of the concentration of 12-hydroxystearic acid–polyethylene glycol copolymer, lecithin and castor oil (CO) as to increase the amount of QU encapsulated while maintaining physicochemical characteristics described in previous studies. To better understand the ability to load and release the drug, we investigated the molecular interactions between QU and NE. Lipid-based NEs were prepared using CO as oily phase and PEG 660-stearate and lecithin as surfactants. Hot solvent diffusion and phase inversion temperature were methods employed to produce NEs. The QU-NEs were investigated for physicochemical characteristics and in vitro drug release. Molecular interactions between QU and the NEs were monitored through the complementary infrared (Fourier transform infrared) and NMR. The results revealed that it was possible to incorporate higher amounts of QU in a lipid-based NE with a reduced size (20?nm). The system developed allow a sustained release of QU probably due to the shell formed by the surfactants around the NE and the flavonoid ordering effect in the emulsion hydrophobic regions, which may reduce the system permeability. 相似文献
79.
Phenolic Profile of Peanut By-products: Antioxidant Potential and Inhibition of Alpha-Glucosidase and Lipase Activities
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Adriano?Costa?de Camargo Marisa?Aparecida?Bismara?Regitano-d’Arce Fereidoon?ShahidiEmail author 《Journal of the American Oil Chemists' Society》2017,94(7):959-971
Free, esterified, etherified and insoluble‐bound phenolics from three samples, namely meal from whole peanuts (MWP), meal from dry‐blanched peanuts (MDBP) and peanut skin (PS) were evaluated for their total phenolic content (TPC), and phenolic profile using HPLC–DAD–ESI–MSn. The TPC was in the order of PS > MWP > MDBP. Among 37 compounds identified 10 were reported for peanuts for the first time. Proanthocyanidins were detected in peanut skin and MWP, but not in MDBP. The presence of peanut skin in MWP rendered up to 9.8‐fold higher scavenging activity towards the DPPH radical as compared with MDBP. Phenolics from all samples and fractions showed inhibition of alpha‐glucosidase and lipase activities, which are key enzymes involved in the absorption of glucose and triacylglycerols, respectively. Therefore, their antioxidant properties as well as their potential role in the management of diabetes and obesity makes them worthy of further consideration as functional food ingredients. 相似文献
80.
Study of the effect of the operating parameters on the separation of bioactive compounds of palm oil by ultra‐high performance supercritical fluid chromatography using a design of experiments approach
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