pH- and thermo-sensitive MTX-loaded magnetic nanocomposites: synthesis,characterization, and in vitro studies on A549 lung cancer cell and MR imaging

In the current study, we proposed a facile method for fabrication of multifunctional pH- and thermo-sensitive magnetic nanocomposites (MNCs) as a theranostic agent for using in targeted drug delivery and magnetic resonance imaging (MRI). To this end, we decorated Fe₃O₄ magnetic nanoparticles (MNPs) with N,N-dimethylaminoethyl methacrylate (DMAEMA) and N-isopropylacrylamide (NIPAAm), best known for their pH- and thermo-sensitive properties, respectively. We also conjugated mesoporous silica nanoparticles (MSNs) to polymer matrix acting as drug container to enhance the drug encapsulation efficacy. Methotroxate (MTX) as a model drug was successfully loaded in MNCs (M-MNCs) via surface adsorption onto MSNs and electrostatic interaction between drug and carrier. The pH- and temperature-triggered release of MTX was concluded through the evaluation of in vitro release at both physiological and simulated tumor tissue conditions. Based on in vitro cytotoxicity assay results, M-MNCs significantly revealed higher antitumor activity compared to free MTX. In vitro MR susceptibility experiment showed that M-MNCs relatively possessed high transverse relaxivity (r₂) of about 0.15?mM^?1·ms^?1 and a linear relationship between the transverse relaxation rate (R₂) and the Fe concentration in the M-MNCs was also demonstrated. Therefore, the designed MNCs can potentially become smart drug carrier, while they also can be promising MRI negative contrast agent.     

Speed limit reduction in urban areas: A before–after study using Bayesian generalized mixed linear models

In fall 2009, a new speed limit of 40 km/h was introduced on local streets in Montreal (previous speed limit: 50 km/h). This paper proposes a methodology to efficiently estimate the effect of such reduction on speeding behaviors. We employ a full Bayes before–after approach, which overcomes the limitations of the empirical Bayes method. The proposed methodology allows for the analysis of speed data using hourly observations. Therefore, the entire daily profile of speed is considered. Furthermore, it accounts for the entire distribution of speed in contrast to the traditional approach of considering only a point estimate such as 85th percentile speed. Different reference speeds were used to examine variations in the treatment effectiveness in terms of speeding rate and frequency. In addition to comparing rates of vehicles exceeding reference speeds of 40 km/h and 50 km/h (speeding), we verified how the implemented treatment affected “excessive speeding” behaviors (exceeding 80 km/h). To model operating speeds, two Bayesian generalized mixed linear models were utilized. These models have the advantage of addressing the heterogeneity problem in observations and efficiently capturing potential intra-site correlations. A variety of site characteristics, temporal variables, and environmental factors were considered. The analyses indicated that variables such as lane width and night hour had an increasing effect on speeding. Conversely, roadside parking had a decreasing effect on speeding. One-way and lane width had an increasing effect on excessive speeding, whereas evening hour had a decreasing effect. This study concluded that although the treatment was effective with respect to speed references of 40 km/h and 50 km/h, its effectiveness was not significant with respect to excessive speeding-which carries a great risk to pedestrians and cyclists in urban areas. Therefore, caution must be taken in drawing conclusions about the effectiveness of speed limit reduction. This study also points out the importance of using a comparison group to capture underlying trends caused by unknown factors.     

Fingerprinting Based Indoor Localization Considering the Dynamic Nature of Wi-Fi Signals

Current localization techniques in outdoors cannot work well in indoors. Wi-Fi fingerprinting technique is an emerging localization technique for indoor environments. However in this technique, the dynamic nature of WiFi signals affects the accuracy of the measurements. In this paper, we use affinity propagation clustering method to decrease the computation complexity in location estimation. Then, we use the least variance of Received Signal Strength (RSS) measured among Access Points (APs) in each cluster. Also we assign lower weights to altering APs for each point in a cluster, to represent the level of similarity to Test Point (TP) by considering the dynamic nature of signals in indoor environments. A method for updating the radio map and improving the results is then proposed to decrease the cost of constructing the radio map. Simulation results show that the proposed method has 22.5% improvement in average in localization results, considering one altering AP in the layout, compared to the case when only RSS subset sampling is considered for localization because of altering APs.

     

Memory and architectural optimizations for soft video encoders

This paper presents a set of platform-independent architectural optimizations for improving the performance of software-based standard video coders. These denote changes that affect the underlying memory model and physical architecture of the encoder with an objective of achieving maximum encoder performance with respect to execution time and memory usage. The coding quality does not suffer due to these modifications because the algorithm itself is not changed. An interface driven methodology has been developed to identify and ameliorate performance bottlenecks for any encoder. Appropriate data flow between components has been proposed so that memory intensive operations including memory accesses and copying are minimized. The proposed methods have been applied to an MPEG4 reference implementation to demonstrate the computational improvements achieved while avoiding any algorithmic modifications. These techniques have been shown to result in improvements in the range of 15–50% in the overall encoding time of a video codec on a general-purpose computing platform. The resulting implementation is also shown to be faster than some well-known open source solutions.     

Global buckling of composite structural insulated wall panels

This paper presents a new type of composites structural insulated panels (CSIPs) for structural wall applications. The proposed composite panel is made of low-cost thermoplastic orthotropic glass/poly-propylene (glass–PP) laminate as a facesheet and expanded polystyrene foam (EPS) as a core with very high facesheet/core moduli ratio. The proposed CSIP walls are intended to overcome problems of traditional Structural Insulated Panels (SIPs) such as termite attack, mold buildups and poor penetration resistance against wind borne debris. This paper investigates the behavior of CSIPs under concentric and eccentric loading. CSIPs specimens failed by global buckling mode in which no debonding was observed. The eccentric specimens failed at load 35% lower than that of the concentric ones. Global buckling formulas for concentric and eccentric loading were presented and validated using the experimental results and were in a good agreement. An equivalent stiffness formula was also developed for sandwich wall under in-plane loading considering the shear deformations effect of the core. Design study for CSIP walls is also presented to help in designing this new type of composite panels.     

Radiological hazards of TENORM in precipitated calcium carbonate generated as waste at nitrophosphate fertilizer plant in Pakistan

The NORM (naturally occurring radioactive material) in phosphate rock is transferred as TENORM (technologically enhanced naturally occurring radioactive material) to phosphatic fertilizers and to the waste generated by the chemical processes. The waste generated at the NP (nitrophosphate) fertilizer plant at Multan in Pakistan is PCC (precipitated calcium carbonate). Thirty samples of the PCC were collected from the heaps of the waste near the fertilizer plant. Activity concentrations of radionuclides in the waste samples were measured by using the technique of gamma ray spectrometry consisting of coaxial type HPGe (high purity germanium) detector coupled with a PC (personal computer) based MCA (multichannel analyzer) through a spectroscopy amplifier. Activity concentrations of ²²⁶Ra, ²³²Th and ⁴⁰K in the waste samples were determined to be 273 ± 23 (173-398), 32 ± 4 (26-39) and 56 ± 5 (46-66) Bq kg⁻¹ respectively. The activity concentration of ²²⁶Ra in the PCC waste was found to be higher than that in naturally occurring calcium carbonate (limestone and marble) and in worldwide soil. Radiological hazard was estimated from indoor and outdoor exposure to gamma rays from the PCC. Indoor annual effective dose was higher than 1 m Sv. Potential radiological pollution in the environment from TENORM in the PCC has also been addressed.     

Preparation of cupric palmitate membrane,its characterization and evaluation of thermodynamically effective fixed charge density

Membrane potentials have been measured across, parchment-supported cupric palmitate membrane separating various 1∶1 electrolytes at concentrations C₁ and C₂ such that C₂=10 C₁. Membrane potential data have been used to calculate transference number of ions, permselectivity and also to derive the thermodynamically effective fixed charge density which is an important characteristic governing the membrane phenomena, by utilizing the generally accepted and most widely used theory of Teorell-Meyer and Sievers as well as the recent theories for membrane potential of Kobatake et al. and Nagasawa et al. based on the principles of nonequilibrium thermodynamics. The values of charge densities derived from different theories were almost the same, confirming thereby the validity of the recently developed theories of membrane potential.     

A Multiband Inductor-Reuse CMOS Low-Noise Amplifier

This paper presents the design and implementation of a new multiband, multistandard CMOS low-noise amplifier (LNA) that reuses inductors for different frequency bands to minimize chip area. The idea is to adaptively reconfigure a CMOS transistor in either common source or common gate configuration to achieve narrow-band (NB) or wide-band (WB) input matching, respectively, while conveniently reusing input and load inductors for both bands. This architecture is suitable for 802.11 a/b/g and Public Safety Broadband (PSB) applications, where the NB configuration covers wireless local area network (WLAN) 802.11 b/g, while the WB configuration accommodates the PSB at 4.9 GHz and WLAN 802.11 a. Two versions of the proposed idea, a tapped-capacitor and a tapped-inductor input-matched LNA, have each been designed and fabricated in 0.13-mum CMOS and measurement results are demonstrated.     

Development of an efficient stabiliser mixture for physical stability of nonfat unfizzy doogh

The effects of locust bean, carboxymethyl cellulose, a mixture of locust bean and carboxymethyl cellulose and Persian gum on different properties of nonfat doogh were studied over a period of 28 days. The results showed that samples containing a mixture of locust bean and carboxymethyl cellulose had the highest stability. Furthermore, the rheological behaviour of the doogh changed from Newtonian to pseudoplastic. Better sensory acceptability was shown for the treatments containing a mixture of locust bean gum and carboxymethyl cellulose. In general, it was shown that a mixture of locust bean and carboxymethyl cellulose could be of practical use in the industrial production of nonfat doogh.     

The effect of natural antioxidants extracted from plant and animal resources on the oxidative stability of soybean oil

The objective of this study was to evaluate and compare the antioxidant activity of protein hydrolyzates isolate (PHI) from Crucian carp (Carassius carassius) fish and cow's intestine along with microwave-assisted olive leaf extract (OLE) encapsulated by Arabic gum and maltodextrin, in soybean oil. The antioxidant activity of PHIs at three concentrations of 200, 500 and 1000 mg/kg and OLE samples containing 70 mg/kg total phenolics during 20 days storage was evaluated by peroxide value, TBA value, p-anisidine value and Rancimat stability test. The fish PHI at concentration of 1000 mg/kg, cow's intestine PHI at 500 and 1000 mg/kg and OLE encapsulated with Arabic gum showed best oxidative protection activity (more than BHT at 100 and 200 mg/kg). OLE had a suitable antioxidant activity in soybean oil and encapsulation improved the thermal stability of phenolic compounds, but on the other hand, it decreased the antioxidant efficiency of OLE.