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81.
Carl Abbott 《Journal of the American Planning Association. American Planning Association》2013,79(4):357-358
Shirley Ross’ Bradford Cityscape was commissioned to be hung in the entrance area of an old wool scouring mill in Bradford that was converted into office suites. It depicts the Town Hall clock tower and the domes of the Alhambra Theatre and the Odeon Cinema. The rectangular shapes represent buildings erected after World War II on bomb-damaged sites where, in the words of the artist, “some of the fine Victorian stone buildings were demolished, replacing stone with steel, concrete, and glass and completely changing the face and character of the city.” Urban revitaliza-tion-but at a price. This image thus represents the mixed assessments presented in this Longer View about Towards an Urban Renaissance, the recent U.K. urban revital-ization plan. The artist creates hand-woven textile hangings and wall-mounted panels using mainly natural fibers depicting scenes of both the natural and built environments. Her work can be seen in many public and private collections across the U.K. and abroad, and on her web site at <www.shirleyross.co.uk>. She works out of her studio in Dews-bury, West Yorkshire. In “Towards an Urban Renaissance: Planning Ideas for Britain's Next Century,” four specialists in urban development and planning from Britain and Canada evaluate Towards an Urban Renaissance, a report recommending ways to achieve urban revitalization in the U.K. The report was prepared by an official task force chaired by architect Richard Rogers and issued in 1999 by the British government. As the contributors note, the report includes parallels to evolving ideas about city planning in the United States, as well as some important differences. 相似文献
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In this study a platform is laid out for the creation of a multitiered surface exhibiting switchable wettability. This is done through a combination of both an acrylate‐based polymer understructure photopolymerized into a pillared array, and selectively placed surface treatments on these pillars. The acrylate‐based polymer is created through a systematic study and is shown to exhibit drastic alterations in material stiffness over a 19 °C temperature transition under aqueous conditions, allowing for stiff, erect pillars in the low temperature state, and pliable pillars that can easily be bent in the high temperature state. The glass transition temperature and onset temperature for the polymer system is found to be 49 and 30 °C, respectively. Three different surface treatments, including trichloro(1H,1H,2H,2H‐perfluorooctyl)silane, polydimethylsiloxane, and polydopamine, are investigated using static contact angle studies, and are selectively deposited onto the pillared surface such that a hydrophobic surface is exposed with the pillars erect, and a hydrophilic surface is exposed with the pillars in the bent state. The surface is shown to transition between first a hydrophobic, then hydrophilic state and return to a hydrophobic state when the investigations are coupled together forming a hierarchical surface structure. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133, 44122. 相似文献
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Dr. Pradeep K. Singh Hao Fan Xiuju Jiang Prof. Dr. Lei Shi Prof. Dr. Carl F. Nathan Prof. Dr. Gang Lin 《ChemMedChem》2016,11(19):2127-2131
N,C‐capped dipeptides belong to a class of noncovalent proteasome inhibitors. Herein we report that the insertion of a β‐amino acid into N,C‐capped dipeptides markedly decreases their inhibitory potency against human constitutive proteasome β5c, while maintaining potent inhibitory activity against human immunoproteasome β5i, thereby achieving thousands‐fold selectivity for β5i over β5c. Structure–activity relationship studies revealed that β5c does not tolerate the β‐amino acid based dipeptidomimetics as does β5i. In vitro, one such compound was found to inhibit human T cell proliferation. Compounds of this class may have potential as therapeutics for autoimmune and inflammatory diseases with less mechanism‐based cytotoxicity than agents that also inhibit the constitutive proteasome. 相似文献
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We consider a general class of optimal control problems with regional pole and controller structure constraints. Our goal is to show that for a fairly general class of regional pole and controller structure constraints, such constrained optimal control problems can be transformed to a new one with a canonical structure. A three-step transformation procedure is used to achieve our goal, which essentially amounts to repeated augmentations of plant dynamics and repeated reductions of the controller. The transformed problem is one of the standard optimal static output feedback with a decentralized and repeated structure. 相似文献
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Lauren Darr Mia Cunicelli Hem Bhandari Kristin Bilyeu Feng Chen Tarek Hewezi Zenglu Li Carl Sams Vince Pantalone 《Journal of the American Oil Chemists' Society》2020,97(1):49-56
Soybean [Glycine max (L.) Merr.] oil with high oleic acid (>75%) has increased oxidative stability and health benefits that are valuable for food, fuel, and industrial products. It has been determined that two naturally occurring mutations in genes FAD2-1A and FAD2-1B can combine to produce high oleic soybeans. The objective of this study was to test the effect of these mutant alleles on seed yield and oil and protein concentration. Molecular markers assisted in the creation of a population of 48 BC3F2:4 lines (93.75% expected genome commonality). Each line was classified into one of four genotypic groups where both FAD2-1A and FAD2-1B genes were either homozygous wild type or mutant, respectively. Twelve lines for each genotypic group were evaluated in three replications at six locations across Tennessee. There was no seed yield difference between the high oleic genotypic group and the other groups (P < 0.05). On the other hand, there were differences in fatty acid profiles and oil and protein concentrations. In combination, the mutant FAD2-1A and FAD2-1B alleles produced a mean of 803.1 g kg−1 oleic acid. This is, on average, approximately 500 g kg−1 more oleic acid compared to soybean lines with only one mutant FAD2-1 allele. The high oleic double mutant group had more total oil (228.0 g kg−1) and protein (401.0 g kg−1) compared to all other genotypic groups (P < 0.05). Overall, this specific combination of mutant FAD2-1A and FAD2-1B alleles appears to generate conventional high oleic soybeans without a yield drag. 相似文献
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