Experiences of Trauma and DNA Methylation Profiles among African American Mothers and Children

Potentially traumatic experiences have been associated with chronic diseases. Epigenetic mechanisms, including DNA methylation (DNAm), have been proposed as an explanation for this association. We examined the association of experiences of trauma with epigenome-wide DNAm among African American mothers (n = 236) and their children aged 3–5 years (n = 232; N = 500), using the Life Events Checklist-5 (LEC) and Traumatic Events Screening Inventory—Parent Report Revised (TESI-PRR). We identified no DNAm sites significantly associated with potentially traumatic experience scores in mothers. One CpG site on the ENOX1 gene was methylome-wide-significant in children (FDR-corrected q-value = 0.05) from the TESI-PRR. This protein-coding gene is associated with mental illness, including unipolar depression, bipolar, and schizophrenia. Future research should further examine the associations between childhood trauma, DNAm, and health outcomes among this understudied and high-risk group. Findings from such longitudinal research may inform clinical and translational approaches to prevent adverse health outcomes associated with epigenetic changes.     

基于BIM理念的绿色建筑新思维

通过BIM精细化设计, 使用统一的数据源, 保持整个设计过程数据的可持续性, 对设计各阶段进行优化, 使设计作品达到绿色建筑设计的要求。此外, 使用数字模拟软件Ecotect、Fluent、Abaqus、Pathfinder等对光照、风环境、荷载、人员疏散进行模拟分析, 并通过模拟结果来优化建筑开窗、建筑遮阳、建筑抗震、建筑疏散以及可再生能源的利用, 提升设计质量, 保证设计的安全性、节能性、环保性和可持续性, 使图书馆具有更适合学习和生活的室内外环境, 达到“人-建筑-自然”三者和谐共生。     

A simple analytical model to predict liquid unloading in the horizontal gas well

An accurate prediction of the critical gas velocity for the liquid loading is of great importance for operators to select the tubing diameter for the newly dril...     

Blockchain and MEC-Assisted Reliable Billing Data Transmission over Electric Vehicular Network:An Actor–Critic RL Approach

Recently, electric vehicles (EVs) have been widely used under the call of green travel and environ-mental protection, and diverse requirements for charg-ing are...     

XiaoMu:an AI-driven assistant for MOOCs

Nowadays,massive open online courses (MOOCs),are at-tracting widespread interest as an alternative education model.Several MOOCs platforms,such as Coursera,edX,...     

非开挖拖管技术在电缆保护管施工中的应用

在城市道路地下电缆保护管下施工中,非开挖拖管施工技术是地下电缆保护管施工的一种比较新型的施工方法.以玉溪市棚户区改造玉交集团10 kV永久性供电工程中电缆保护管在穿越龙马路施工时采用的非开挖拖管技术为例,浅谈该技术在本项目中的应用.     

新型二氧化硫传感器的制备

制成一种新型无参比电极、由NASICON和YSZ2种固体电解质及Na₂SO₄辅助电极构成的二氧化硫传感器。实验结果表明,该传感器对二氧化硫产生Nernst响应。由于这种传感器采用了平面结构,参比电极和工作电极处于相同气氛中,消除了氧气的影响和密封问题,这种结构有利于传感器的微型化和多组元复合传感。     

板形板厚综合系统的解耦神经网络预测控制方法

给出了板形板厚综合控制模型,提出了基于TH神经网络的动态矩阵设计方法并分析了其收敛特性.使用不变性原理对板形板厚综系统进行了解耦设计,并对板形板厚解耦神经网络预测控制系统,进行了仿真研究.结果表明神经网络可在儿百ns的时间内达到稳定状态,不仅满足了轧钢过程的快速性要求,而且控制精度也得到了提高.     

喷射沉积过程中气体流场的测定及数值模拟

采用组合式皮托管测量的方法测量了喷射沉积过程中的雾化气体流场,并基于神经网络的方法对流场进行数值模拟,获得了较为精确的雾化气体压力与流场中轴向气体速度之间的关系,实现了对不同气压下气体流场的预测。     

基于Bayes分析小批量生产量控制与诊断

应用Bayes分析方法,充分利用历史信息,得出优化的参数估计,从而得出小批量控制图与选控图,并实现了小批量情形的两种质量诊断理论。通过实例表明该理论估计符合实际。