肇庆东雅苑一期园林环境的设计与施工实践

东雅苑在有限的绿地空间中，突破了以往的绿化种植模式，构建高效益的复合植物群落。各个景区具有鲜明的主题和构思特点，融观赏性、娱乐性、趣味性和服务性于一体，受到了房地产商和业主们的欢迎和认可。     

Synergistic Effects of Venetoclax and Daratumumab on Antibody-Dependent Cell-Mediated Natural Killer Cytotoxicity in Multiple Myeloma

The prognosis of multiple myeloma (MM) has drastically improved owing to the development of new drugs, such as proteasome inhibitors and immunomodulatory drugs. Nevertheless, MM is an extremely challenging disease, and many patients are still refractory to the existing therapies, thus requiring new treatment alternatives. Venetoclax is a selective, orally bioavailable inhibitor of BCL-2 that shows efficacy in MM not only as a single agent but also in combination therapy, especially for MM patients with translocation t(11;14). However, many patients are refractory to this drug. Here, we treated the MM cell lines KMS12PE and KMS27 with a combination treatment of venetoclax targeting BCL-2 and daratumumab targeting CD38 to evaluate the synergistic cytotoxicity of these drugs in vitro. MM cell lines were co-cultured with natural killer (NK) cells at an effector:target ratio of 0.3:1 in the presence of serial concentrations of daratumumab and venetoclax, and the resulting apoptotic MM cells were detected by flow cytometry using annexin V. These results indicated that the antibody-dependent cell-mediated NK cytotoxicity was enhanced in KMS12PE and KMS27 cells harboring t(11;14) with a high BCL-2 expression, suggesting that the combination treatment of venetoclax and daratumumab should be especially effective in patients with these characteristics.     

微结构光纤激光器件

由于微结构光纤灵活多变的结构特点,使得以其为增益介质的光纤激光器件,具有比普通光纤激光器件更加优异的性能.本文结合国际上微结构光纤激光器件的最新研究进展情况,概述了微结构光纤作为增益介质的独特特性、微结构光纤激光器件的理论分析方法和掺铒、掺镱以及喇曼微结构光纤激光器件的特点.     

Scavenging effect of tea catechins and their epimers on superoxide anion radicals generated by a hypoxanthine and xanthine oxidase system

Catechins are a major group of polyphenolic compounds contained in abundance in green tea. Using electron spin resonance spectroscopy along with a spin‐trapping agent, the scavenging effect of tea catechins and their corresponding epimers against superoxide anion radicals generated by a hypoxanthine and xanthine oxidase reaction system was evaluated. The presence of 3′,4′,5′‐trihydroxyl groups attached to the B‐ring of the flavan skeleton of tea catechins elevated their radical‐scavenging efficiency in comparison to those with 3′,4′‐dihydroxyl groups. There were no significant differences between the four dominant tea catechins and their corresponding epimers with regard to radical‐scavenging ability. Under the different spin‐trapping agent concentrations, the sigmoid curves of reducing spin‐trapping adducts produced by tea catechins were shifted leftward, suggesting that a likely possible action of tea catechins is to scavenge superoxide anion radicals directly, not to inhibit the function of xanthine oxidase. Although caffeine is also known as a major ingredient of tea, its superoxide anion radical‐scavenging effect was much weaker than that of the catechin family. It is concluded that tea catechins and their epimers serve as powerful antioxidants for directly eliminating superoxide anion radicals, and may be useful in the prevention of diseases relating to in vivo oxidative stress. © 2000 Society of Chemical Industry     

Supercritical hydrothermal synthesis and in situ organic modification of indium tin oxide nanoparticles using continuous-flow reaction system

ITO nanoparticles were synthesized hydrothermally and surface modified in supercritical water using a continuous flow reaction system. The organic modification of the nanoparticles converted the surface from hydrophilic to hydrophobic, making the modified nanoparticles easily dispersible in organic solvent. The addition of a surface modifier into the reaction system impacted the crystal growth and particle size as well as dispersion. The particle size was 18 nm. Highly crystalline cubic ITO with a narrow particle size distribution was obtained. The advantages of short reaction time and the use of a continuous reaction system make this method suitable for industrial scale synthesis.     

飞行器薄壁件柔性工装定位/支承阵列优化自生成研究

针对开发飞行器大型薄壁件柔性工艺装备系统的需求,对该类新型工装系统运行模式的优化生成问题进行了研究。通过分析系统结构和运行原理建立了系统模型,并根据自生成原理,提出了系统运行模式的优化自生成方法。该方法基于工件自身信息和加工过程自身信息,通过有限元分析与遗传算法相结合的自寻优途径,经过不断自身进化,实现定位/支承阵列的全局优化,克服了传统方法通过外部指令,由操作人员根据经验调整系统运行模式而存在的问题。实例验证表明,该方法可使柔性工装系统中定位/支承阵列布局的拓扑形态和分布密度处于最优状态,从而使系统资源得到最佳利用,为柔性工艺装备系统的高质高效运行奠定了基础。     

螺纹参数测量中工件定位误差分析和补偿

利用齐次坐标变换方法从理论上研究了单针扫描式螺纹测量仪的工件定位误差模型,并考虑探针尖头的几何形状,建立了更加精准的曲线方程。以该曲线作为最小二乘拟合曲线,根据数学模型的特点和参数的取值范围,采用改进的单纯形-模拟退火(SMSA)算法,通过对标准件的测量,求解模型参数,补偿对应误差,减小了简单直线拟合的模型误差。基于该方法,在自主研发的测针式螺纹测量仪上进行了实验验证,结果表明,所述模型更符合实际情况,能够有效地减小工件定位误差。     

铬天青S光度法测定塑料薄膜镀铝厚度

采用铬天青S光度法测定镀铝薄膜中铝的含量,然后由铝的密度和单位薄膜面积的镀铝量计算出膜镀铝的厚度。研究了铝与铬天青S(CAS)的显色反应,结果表明,在pH 5.5的缓冲溶液中,铝离子与铬天青S(CAS)生成络合物,最大吸收波长为610 nm,表观摩尔吸光系数ε=3.89×10⁴ L·mol^-1·cm^-1。在优化条件下,铝的质量浓度在0.004～0.20 μg/mL与吸光度呈良好的线性关系,检测限为0.004 μg/mL。对塑料薄膜镀铝样品进行加标回收试验,测得铝的加标回收率在97%～102%之间。方法测定了塑料薄膜镀铝样品的镀铝厚度,测定结果的相对标准偏差(n=6)小于3%。     

乳胶基质微乳液低温快速发泡技术的研究

通过制备以亚硝酸钠为内相,油相及表面活性剂为外相的微乳液,在低温和高温环境下对乳胶基质进行敏化.试验结果表明,在低温25℃时,采用微乳液发泡技术在12 min内可以完成敏化,敏化后的基质密度为1.09g/cm3,并具备良好的爆轰性能,采用常规发泡技术在低温情况下30 min内无法完成敏化要求.在高温情况下,微乳液发泡技术在不需要酸催化的作用下,可以在3 min内达到理想的敏化效果,而常规发泡技术则需要在酸催化作用下,经过15 min才可以达到理想的敏化效果.     

表面等离子体共振技术对过氧化氢的检测

表面等离子体激元共振技术是一种通过观察芯片金属薄膜表面厚度变化产生信号的光学技术,具有实时、灵敏度高、免标记等优点,本文通过辣根过氧化物酶的酶催化作用对过氧化氢进行实时快速检测。信号强度与过氧化氢浓度呈线性关系,辣根过氧化物酶共价结合至金膜表面保持了酶的活性。和其它方法相比较,该方法为过氧化氢的检测提供了一种选择。