A Newly Developed Non, Destructive Tritium Measurement Technique and Its Application to V-4Cr-4Ti Alloy

A non-destructive and in-situ technique for the measurement of tritium in materials, namely β-ray-induced X-ray spectrometry （BIXS）, has been developed recently. In the present study a V-4Cr-4Ti alloy was pre-heated at 1000℃ for 2 h to form a recrystallization structure before the tritium absorption experiments were conducted. Firstly the hydrogen isotope gas was charazterized by means of a quadrupole mass spectrometer （QMS） and a small-sized ionization chamber. Then hydrogen isotope absorption tests of V-4Cr-4Ti alloy were performed at 400 ℃ and the atomic concentration of hydrogen isotope in V-4Cr-4Ti alloy was estimated as 0.17% with a tritium content of approximately 2.5 ppm. Experimental results indicate that BIXS is a quite useful tool for quantitatively measuring the tritium content and tritium distribution in the surface layers of vanadium alloys and no strong trapping effects of tritium exist in the pre-heated V-4Cr-4Ti alloy.     

民国河东盐商巨擘——仝少宣

仝少宣是民国时期河东盐商的巨擘,长袖善贾,善于经营,是清末至民国27年(1938年)执河东盐商之牛耳的驭手。他的经营业绩和经营理念,深深影响了一代盐商。笔者经十年询访,搜集整理,撰写成如下论文,就教于各位盐业史研究同仁。     

小纸层析法快速测定^99mTc—HMPAO放射化学纯度

采用小纸层析系统１：１的氯仿／四氢呋喃展开剂分析＾９９ｍＴｃ－ＨＭＰＡＯ的放射化学纯度，并与两个薄层析系统和一个纸层析系统的方法作比较。配对ｔ检验结果表明两种方法测定的放射化学纯度无显著差异；放射化学纯度在７４．２％－９６．４％，小纸层析法与薄层／纸层析法紧密相关，回归公式ｙ＝１．００６ｘ－０．３２３。     

准分子激光泵浦的皮秒染料激光器

利用准分子激光泵浦猝灭式染料激光器，获得了３０ｐｓ的可调谐染料激光脉冲输出。     

空间柔性机械臂三维动力学数值仿真

本文应用ｄ＇Ａｌｅｍｂｅｒｔ－Ｌａｇｒａｎｇｅ原理，对由基座、（ｎ－１）个柔性连杆及端部负载组成，相互用柱铰连接的柔性链式多体系统进行建模；对在空间技术中，具有一刚杆，两柔杆加上刚性负载所组成的三维机械臂系统，采用Ｇｅａｒ算法进行数值仿真。仿真结果比较符合实际，从而在柔性多体系统的数学模型为刚性常微分方程的情况下，为解决其数值仿真问题，特别是三维问题的数值仿真取得了进展。     

Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide

BACKGROUND: Plasminogen activator inhibitor type 1 (PAI-1) is an important endogenous regulator of the fibrinolytic system. Reduction of PAI-1 activity has been shown to enhance dissolution of blood clots. Like other serpins, PAI-1 binds covalently to a target serine protease, thereby irreversibly inactivating the enzyme. During this process the exposed reactive-centre loop of PAI-1 is believed to undergo a conformational change becoming inserted into beta sheet A of the serpin. Incubation with peptides from the reactive-centre loop transform serpins into a substrate for their target protease. It has been hypothesised that these peptides bind to beta sheet A, thereby hindering the conformational rearrangement leading to loop insertion and formation of the stable serpin-protease complex. RESULTS: We report here the 1.95 A X-ray crystal structure of a complex of a glycosylated mutant of PAI-1, PAI-1-ala335Glu, with two molecules of the inhibitory reactive-centre loop peptide N-Ac-TVASS-NH2. Both bound peptide molecules are located between beta strands 3A and 5A of the serpin. The binding kinetics of the peptide inhibitor to immobilised PAI-1-Ala335Glu, as monitored by surface plasmon resonance, is consistent with there being two different binding sites. CONCLUSIONS: This is the first reported crystal structure of a complex formed between a serpin and a serpin inhibitor. The localisation of the inhibitory peptide in the complex strongly supports the theory that molecules binding in the space between beta strands 3A and 5A of a serpin are able to prevent insertion of the reactive-centre loop into beta sheet A, thereby abolishing the ability of the serpin to irreversibly inactivate its target enzyme. The characterisation of the two binding sites for the peptide inhibitor provides a solid foundation for computer-aided design of novel, low molecular weight PAI-1 inhibitors.     

颗粒表面改性法制备PTC粉体的研究

本文介绍了一种通过液相颗粒表面改性技术添加二次掺杂物来制备ＰＴＣ粉体的新方法。即将烧结助熔剂Ａｌ２Ｏ３，ＳｉＯ２以及受主杂质ＭｎＯ采用溶液形式，包裹在ＢａＴｉＯ３基粉体颗粒表面进行改性，由此可以得到二次掺杂物Ａｌ２Ｏ３、ＳｉＯ２和ＭｎＯ分布均匀的ＰＴＣ粉体。     

Studies on purification and some properties of nisin from Lactococcus lactis subsp. lactis Al2

Protoporphyria is a genetic disorder in which patients may develop severe protoporphyrin-induced liver damage and require transplantation. Because unique problems occur in the perioperative period and because excess production of protoporphyrin by the bone marrow continues after liver transplantation, the efficacy of this procedure for protoporphyric liver disease is uncertain. We present follow-up of nine patients who underwent liver transplantation. Two patients died within 2 months of transplantation, one from complications of abdominal bleeding and the other from sepsis after bowel perforations. The remaining seven patients had follow-up at 14 months to 8 years after transplantation (mean, 3.8 years). Two of the seven had suffered skin burns from exposure to operating room lights, which healed without scarring. Three had axonal neuropathies in the postoperative period requiring prolonged mechanical ventilation, and motor defects persisted in two. Five patients had normal liver chemistries at follow-up (mean, 3.5 years), with liver biopsy results normal or showing mild portal triad abnormalities, but erythrocyte protoporphyrin levels remained significantly elevated (1,765 +/- 365 mcg/dL; normal, < 65). The other two patients, both of whom had rejection, cytomegalovirus infection, and biliary tract obstruction requiring endoscopic therapy, had a recurrence of protoporphyric liver disease as indicated by liver biopsy features. One died 5 years after transplantation from complications of the liver disease. The other was stable 3.3 years after transplantation and was being monitored for possible retransplantation. Thus, liver transplantation can be performed successfully in patients with protoporphyric liver disease, with intermediate survival rates comparable to the general transplant population. However, disease may recur in the graft, particularly if there are complications that cause cholestasis.     

漳泽水库最优兴利调度研究

漳泽水库供水能力下降。优化调度方式是提高水库效益的最有效途径。通过采用随机动态规划方法与模拟模型交互运算得到现行控制水位的水库优化调度图。采用同样方法对不同控制水位的水库运行方式进行优化调度，选出的规划水库最优控制水位为汛限水位９０４ ．５ ｍ ，正常高水位９０５ ．５ ｍ 。优化的控制水位方案在保障水库防洪安全的前提下可供给城市生活和工业用水６ ３００ 万ｍ３ ，较现行控制水位下的供水量提高１ ２５５ 万ｍ３ 。但农业用水仍然不足，应采取一定措施给予解决，如对灌区工程进行改造，因地制宜采取不同节水措施和污水回用等。