鄂钢140 t/h干熄焦技术特点及改进

鄂钢140 t/h干熄焦秉承国产化干熄焦技术优点,同时具有多项技术创新,并对工艺和设备进行技术改进和完善。生产稳定,效益明显。     

基于ASP的网站后台安全解决方案

本文系统的分析了“黑客”对于ASP网站后台的入侵手段,结合我国网站管理员水平及经验参差不齐的现状,给出了简单且有效的ASP网站后台安全解决方案。使大多数编程水平不高的管理员也能杜绝网站后台的安全隐患。     

提高E^2PROM中NMOS管源漏穿通电压的实验研究

为了提高Ｅ＾２ＰＲＯＭ中Ｎ管源漏穿通电压，用实验的方法对制造工艺进行了研究。结果表明，高能量注入是提高ＶＰＴ的有效手段，但受到ｐｎ结击穿的限制，只适用于低区短沟Ｎ管；ＤＤＤ工艺大幅度高ＶＰＴ，但ｐｎ结击穿电压低于２０Ｖ，不能应用于高压ＭＯＳ管；采用适量的防穿通注入和适当增大沟道长度为最理想的工艺途径。     

NaI多道脉冲幅度分析系统在燃料元件破损监测中的应用研究

介绍了船用堆燃料元件破损监测中较常用的两种方法.通过分析其缺陷,提出了用NaI多道脉冲幅度分析系统测量特征核素(131I、137Cs)的方法,有效避免了监测中的干扰因素的影响,降低了定量监测中的误报率,提高了燃料元件破损监测的效率和置信度.     

Glucosamine-induced insulin resistance in 3T3-L1 adipocytes is caused by depletion of intracellular ATP

Glucosamine, which enters the hexosamine pathway downstream of the rate-limiting step, has been routinely used to mimic the insulin resistance caused by high glucose and insulin. We investigated the effect of glucosamine on insulin-stimulated glucose transport in 3T3-L1 adipocytes. The Delta-insulin (insulin-stimulated minus basal) value for 2-deoxyglucose uptake was dramatically inhibited with increasing concentrations of glucosamine with an ED50 of 1.95 mM. Subcellular fractionation experiments demonstrated that reduction in insulin-stimulated 2-deoxyglucose uptake by glucosamine was due to an inhibition of translocation of both Glut 1 and Glut 4 from the low density microsomes (LDM) to the plasma membrane. Analysis of the insulin signaling cascade revealed that glucosamine impaired insulin receptor autophosphorylation, insulin receptor substrate (IRS-1) phosphorylation, IRS-1-associated PI 3-kinase activity in the LDM, and AKT-1 activation by insulin. Measurement of intracellular ATP demonstrated that the effects of glucosamine were highly correlated with its ability to reduce ATP levels. Reduction of intracellular ATP using azide inhibited Glut 1 and Glut 4 translocation from the LDM to the plasma membrane, insulin receptor autophosphorylation, and IRS-1 tyrosine phosphorylation. Additionally, both the reduction in intracellular ATP and the effects on insulin action caused by glucosamine could be prevented by the addition of inosine, which served as an alternative energy source in the medium. We conclude that direct administration of glucosamine can rapidly lower cellular ATP levels and affect insulin action in fat cells by mechanisms independent of increased intracellular UDP-N-acetylhexosamines and that increased metabolism of glucose via the hexosamine pathway may not represent the mechanism of glucose toxicity in fat cells.     

Lack of familial clustering of hepatitis C virus infection

BACKGROUND: Although transmission of hepatitis C virus (HCV) through parental exposure is well documented, it is still controversial whether familial clustering of HCV occurs. METHODS: To investigate risk factors for HCV infection, 109 cases and 84 non-infected controls were studied. In addition, 250 family members (104 men, 146 women) of cases and 170 family members of controls (64 men, 106 women) were tested for HCV infection using an anti-HCV antibody, alanine aminotransferase (ALT), and reverse transcribed polymerase chain reaction (RT-PCR). RESULTS: In the case-control analysis, people aged > or =60 were almost three times more likely to be infected by HCV than those aged <40. Risk of HCV infection was most strongly related to a history of blood transfusion (OR = 12.6, 95% CI: 4.3-36.5) followed by a history of jaundice (OR = 4.1, 95% CI: 1.3-12.6). Only one family member of cases and no-one related to the controls had HCV infection. CONCLUSIONS: These results suggest that, in Korea, age and parenteral exposure, such as a blood transfusion, are risk factors for HCV infection and familial clustering of HCV infection, if it occurs, is rare.     

Mixed variable optimization using Taguchi's orthogonal arrays

Taguchi's orthogonal arrays for robust design are used in this paper in a nontraditional way to solve a mixed continuous-discrete structural optimization problem. The factors of an orthogonal array correspond to the members of a structure and the levels of each factor correspond to the material choices of each member. Based on the number of factors to be studied and the number of levels of each factor, an appropriate orthogonal array is selected for each specific problem. The number of rows of the orthogonal array correspond to the number of experiments (i.e. continuous sizing optimizations) to be conducted. The response of these experiments, which are the weight of the optimal designs corresponding to different material settings, are then used to calculate the mean effect of each factor level. Some possible optimal material settings can then be determined. Three examples are presented in this paper. Analysis using Taguchi's orthogonal arrays was able to isolate several near optimal or optimal designs. The accuracy and efficiency of the proposed method compared to more traditional solution methodologies are also discussed.     

Medullary thyroid carcinoma: genetic advances, treatment recommendations, and the approach to the patient with persistent hypercalcitoninemia

Medullary thyroid cancer is a tumor of the thyroid C cells that occurs in sporadic and hereditary clinical settings. Genetic testing of at-risk individuals is available and has been applied to patient management. Plasma calcitonin levels are a sensitive marker for the presence of disease. Surgery offers the best hope for cure and also is an effective modality for managing metastatic and recurrent disease.     

SVPWM三相电压型逆变器的仿真研究

以三相电压型逆变器为基础,根据空间矢量脉宽调制（SVPWM）基本原理详细分析研究了电压矢量作用时间和扇区分配问题,以α-β坐标为基础,建立了互差π/3的x-y-z时间坐标系,提出了不同扇区矢量作用时间长短根据期望极值判断的原则。介绍了MATLAB中M文件编程的仿真方法,建立了MATLAB程序嵌入式主要功能模块,逆变器采用数字PID控制,利用Simulink对系统进行了综合仿真分析及试验,给出了仿真及实验波形,为实现SVPWM逆变器的数字控制提供参考。     

无线ILC系统测控信号延时效应补偿方法

针对通过无线信道进行测控信号传输的远程迭代学习控制( ILC)系统,研究信号传输延时对控制系统性能的影响.分析了测控信号延时情况下ILC系统的收敛性问题,通过引入预控制向量,提出了ILC系统信道延时效应补偿的向量更新方法.数值仿真结果表明了所提方法的有效性.