Imaging‐Guided Combined Photothermal and Radiotherapy to Treat Subcutaneous and Metastatic Tumors Using Iodine‐131‐Doped Copper Sulfide Nanoparticles

Combining different therapeutic strategies to treat cancer by overcoming limitations of conventional cancer therapies has shown great promise in both fundamental and clinical studies. Herein, by adding ¹³¹I when making iodine‐doped CuS nanoparticles, CuS/[¹³¹I]I nanoparticles are obtained, which after functionalization with polyethylene glycol (PEG) are used for radiotherapy (RT) and photothermal therapy (PTT), by utilizing their intrinsic high near‐infrared absorbance and the doped ¹³¹I‐radioactivity, respectively. The combined RT and PTT based on CuS/[¹³¹I]I‐PEG is then conducted, achieving remarkable synergistic therapeutic effects as demonstrated in the treatment of subcutaneous tumors. In the meanwhile, as revealed by bimodal nuclear imaging and computed tomography (CT) imaging, it is found that CuS/[¹³¹I]I‐PEG nanoparticles after being injected into primary solid tumors could migrate to and retain in their nearby sentinel lymph nodes. Importantly, the combined RT and PTT applied on those lymph nodes to assist surgical resection of primary tumors results in remarkably inhibited cancer metastasis and greatly prolonged animal survival. In vivo toxicology studies further reveal that our CuS/I‐PEG is not obviously toxic to animals at fourfold of the treatment dose. This work thus demonstrates the potential of combining RT and PTT using a single nanoagent for imaging‐guided treatment of metastatic tumors.     

基于MC9S12XET256MAL的汽车车身控制模块系统电路设计

本设计是以Freescale导体的MC9S12XET256MAL设计车载车身控制单元,主要实现功能包含车窗控制,车灯控制,背光控制,RKE,雨刮,清洗电机,防盗报警,中控门锁,行车喇叭,安全指示灯,CAN总线,LIN总线。增强汽车的安全、舒适和方便性。用户可以对外部按键操作实现相应功能,同时采集相关传感器自动实现相关功能,例如雨刮,防盗报警。利用总线将显示系统、驾驶员信息系统、导航系统、计算机网络系统、状态监测与故障诊断系统等连接。     

环境监测质量管理信息系统的应用研究

互联网环境质量管理信息系统的开发和运用能够有效的为全国环境监测报告提供有力的数据支持,同时完善环境监测质量管理信息系统也是保证加强全国环境监测的基本要求,本文对信息系统在环境监测中的应用进行了研究,希望能够对提高环境质量有所帮助。     

裸眼3D系统SD卡FPGA读取显示研究

SD卡可为便携式裸眼3D设备提供数据来源,图像存储于SD卡中,FPGA以SPI协议方式读出,再经过FIFO和SDRAM进行数据缓存,通过接口输入显示器显示.探讨了通过FPGA器件读取SD卡图像进行显示的实现方法,得出了SD卡文件读取及显示的可行逻辑设计.系统性能经过初步验证,可行性良好.     

两源交叉眼与多源线阵交叉眼的干扰性能分析

交叉眼干扰是单脉冲雷达最有效的干扰方式之一,增益是衡量交叉眼干扰性能的重要指标.本文在两源反向交叉眼干扰(TRCJ,Two source Retro-directive Cross-eye Jamming)和多源线阵反向交叉眼干扰(LMRCJ,Linear ar-ray Multi-source Retro-direc...     

电视台信息技术系统运维服务管理体系探究

电视台信息技术系统运维服务管理体系的正常运行,不但可以有效控制播控系统的运行质量,而且能够为演播室的节目录制工作提供必要的技术支撑.基于此,概括总结电视台信息技术系统运维服务管理体系的设计理念和实践情况,论述电视台信息技术系统运维服务管理体系的发展对策.     

利用信号的循环平稳特性进行相干源的波达方向估计

本文提出一种修正的ＳＣ－ＳＳＦ方法,该方法适用于宽带和窄带源,不仅可解决循环相关源的问题,而且具有更好的噪声抑制特性,用蒙特卡下实该方法噪声抑制性能优于ＳＣ－ＳＳＦ〈并具有对相同循环频率的多个循环盯关源进行ＦＤＯＡ估计的能力。     

Low Complexity Carrier Frequency Offset and Channel Estimation for Multiuser OFDMA Networks

Wireless Personal Communications - Multiple carrier frequency offsets exist in the orthogonal frequency-division multiple access (OFDMA) uplink receivers, and consequently induce inter-carrier...     

SiC轻量化主镜液压whiffletree支撑系统的改进

针对2 m SiC轻量化主镜设计了液压whiffletree被动支撑系统,通过在轴向液压支撑点处并联杠杆配重机构的方式,实现了不同支撑圈上轴向支撑力的优化分配,将轴向支撑下主镜的镜面变形RMS值从7.1 nm优化到4.8 nm.针对SiC主镜热膨胀率大的特性,提出了采用具有热解耦能力的切向连杆结合液压whiffletree的侧向支撑系统,并借助于有限元法预算出主镜光轴水平状态下侧向支撑引起的镜面变形误差RMS值为39.7 nm.当温差为20 ℃时,轴向和侧向支撑结构作用下的主镜镜面变形误差RMS值仍保持在4.8 nm,验证了侧向支撑良好的热解耦能力.     

LDPC码加权比特翻转译码算法的低复杂度提前停止准则

近年来,针对LDPC码置信传播(BP)译码算法的提前停止准则的研究已经有了很多,但设计适合加权比特翻转(WBF)译码算法的提前停止准则却研究甚少。依据对WBF算法的全新理解方式,该文提出一种实现简单、适用性强的WBF算法提前停止准则,它能在译码的初始阶段检测绝大多数不可纠错的帧。仿真结果表明,基于提前停止准则的WBF算法在性能损失可以忽略的条件下,极大地降低迭代次数,在实现复杂度和性能之间达到了很好的折中。