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91.
Associations between apolipoprotein E genotype and circulating F<Subscript>2</Subscript>-isoprostane levels in humans 总被引:1,自引:0,他引:1
Dietrich M Hu Y Block G Olano E Packer L Morrow JD Hudes M Abdukeyum G Rimbach G Minihane AM 《Lipids》2005,40(4):329-334
Apolipoprotein E (apoE), an important determinant of plasma lipoprotein metabolism, has three common alleles (&#949;2, &#949;3, and
&#949;4). Population studies have shown that the risk of diseases characterized by oxidative damage, such as coronary heart disease
and Alzheimer&#8217;s disease, is significantly higher in &#603;4 carriers. We evaluated the association between apoE genotypes and plasma
F2-isoprostane levels, an index of lipid peroxidation, in humans. Two hundred seventy-four healthy subjects (104 males, 170
females; 46.9±13.0 yr; 200 whites, 74 blacks; 81 nonsmokers, 64 passive smokers, and 129 active smokers) recruited for a randomized
clinical antioxidant intervention trial were included in this analysis. ApoE genotype was determined by PCR and restriction
enzyme digestion. Free plasma F2-isoprostane was measured by GC-MS. Genotype groups were compared using multiple regression analysis with adjustment for sex,
age, race, smoking status, body mass index, plasma ascorbic acid, and &#946;-carotene. Subjects with &#949;3/&#949;4 and &#949;4/&#949;4 genotype (&#949;4-carriers)
and with &#949;2/&#949;3 and &#949;3/&#949;3 (non-&#949;4-carriers) were pooled for analysis. In subjects with high cholesterol levels (total cholesterol
above 200 mg/dl), plasma F2-isoprostane levels were 29% higher in &#949;4 carriers than in non-&#949;4-carriers (P=0.0056). High-cholesterol subjects that are &#949;4 carriers have significantly higher levels of lipid peroxidation as assessed
by circulating F2-isoprostane levels. 相似文献
92.
Sibel Akgün Gülsüm Ekici Nilüfer Mutlu Necati Beşirli Baki Hazer 《Journal of Polymer Research》2007,14(3):215-221
Modification of chitosan by grafting of vinyl butyrate was carried out in homogeneous phase using potassium persulfate as
redox initator and 1.5% acetic acid as solvent. The percent grafting and grafting efficiency were analysed and the high grafting
efficiency up to 94% was observed. The effects of reaction variables such as monomer concentration, initiator concentration,
temperature and reaction time were investigated. It was observed that the solubility of chitosan was markedly reduced after
grafting with vinyl butyrate. The grafted product is insoluble in common organic solvents as well in dilute organic and inorganic
acids. Characterization of the graft copolymers were carried out by using Fourier Transform Infrared Spectroscopy (FTIR),
Differential Scanning Calorimetry (DSC) and Scanning Electron Microscopy (SEM) technics. Characteristic signal of carbonyl
group was observed at 1,731 cm&#8722;1 which belongs to the poly vinyl butyrate segments in the graft copolymer. The melting transition of the chitosan main chain
in the copolymer shifted to 124°C from its original value 101°C. In addition to these, we have also studied topology of the
graft copolymer and the SEM micrograph showed continuous homogenous matrix which means there is no phase separation. 相似文献
93.
M.M. Korsukova V.N. Gurin Y. Yu L.-E. Tergenius T. Lundstrm 《Journal of Alloys and Compounds》1993,190(2):185-187
Single crystals of the new phase TmAlB14 were grown using the high-temperature solution method. The crystal structure of TmAlB14 was refined from X-ray powder diffraction data using the Rietveld method. The structure is of MgAlB14-type with the space group Imma and unit cell parameters a = 5.8212(3) Å, B = 10.3837(2) Å and C = 8.1762(3) Å. The final, conventional R-valve and profile R-value are 0.031 and 0.064, respectively. The structure is characterized by a partial occupancy of both metal positions and a splitting of the thulium atomic position. 相似文献
94.
95.
Johanna Nellen Kai Driessen Martin Neuhäußer Erika Ábrahám Benedikt Wolters 《Information Systems Frontiers》2016,18(5):927-952
In this paper we address the safety analysis of chemical plants controlled by programmable logic controllers (PLCs). We consider a specification of the control program of the PLCs, extended with the specification of the dynamic plant behavior. The resulting hybrid models can be transformed to hybrid automata, for which advanced techniques for reachability analysis exist. However, the hybrid automata models are often too large to be analyzed. We propose two counterexample-guided abstraction refinement (CEGAR) approaches to keep the size of the hybrid models moderate. 相似文献
96.
This paper presents an approach to modular contract-based verification of discrete-time multi-rate Simulink models. The verification approach uses a translation of Simulink models to sequential programs that can then be verified using traditional software verification techniques. Automatic generation of the proof obligations needed for verification of correctness with respect to contracts, and automatic proofs are also discussed. Furthermore, the paper provides detailed discussions about the correctness of each step in the verification process. The verification approach is demonstrated on a case study involving control software for prevention of pressure peaks in hydraulics systems. 相似文献
97.
98.
Yazdan Shirvany Fredrik Edelvik Stefan Jakobsson Anders Hedström Mikael Persson 《Applied Soft Computing》2013,13(5):2515-2525
Surgical therapy has become an important therapeutic alternative for patients with medically intractable epilepsy. Correct and anatomically precise localization of an epileptic focus is essential to decide if resection of brain tissue is possible. The inverse problem in EEG-based source localization is to determine the location of the brain sources that are responsible for the measured potentials at the scalp electrodes. We propose a new global optimization method based on particle swarm optimization (PSO) to solve the epileptic spike EEG source localization inverse problem. In a forward problem a modified subtraction method is proposed to reduce the computational time. The good accuracy and fast convergence are demonstrated for 2D and 3D cases with realistic head models. The results from the new method are promising for use in the pre-surgical clinic in the future. 相似文献
99.
100.
Barbara Yersin Jonathan Maïm Fiorenzo Morini Daniel Thalmann 《The Visual computer》2008,24(10):859-870
Real-time crowd motion planning requires fast, realistic methods for path planning as well as obstacle avoidance. In a previous
work (Morini et&nbsp;al. in Cyberworlds International Conference, pp. 144&#8211;151, 2007), we introduced a hybrid architecture to handle real-time motion planning of thousands of pedestrians. In this article, we
present an extended version of our architecture, introducing two new features: an improved short-term collision avoidance
algorithm, and simple efficient group behavior for crowds. Our approach allows the use of several motion planning algorithms
of different precision for regions of varied interest. Pedestrian motion continuity is ensured when switching between such
algorithms. To assess our architecture, several performance tests have been conducted, as well as a subjective test demonstrating
the impact of using groups. Our results show that the architecture can plan motion in real time for several thousands of characters.
相似文献
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