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G Hendrickson R K Anderson P D Clayton J Cimino G M Hripcsak S B Johnson M McCormack S Sengupta S Shea R Sideli 《M.D. computing : computers in medical practice》1992,9(1):35-42
Over the past seven years, Columbia-Presbyterian Medical Center has been planning and implementing an integrated academic information management system. Accomplishments to date include establishing an institutional information architecture, installing a campus-wide network of workstations, recruiting the staff needed to develop and implement the system, and developing various applications. This paper presents the rationale and steps involved in these accomplishments, as well as data on use of the system so far. 相似文献
13.
GL Anderson KN Caldwell LR Beuchat PL Williams 《Canadian Metallurgical Quarterly》2003,66(9):1543-1549
Free-living nematodes may harbor, protect, and disperse bacteria, including those ingested and passed in viable form in feces. These nematodes are potential vectors for human pathogens and may play a role in foodborne diseases associated with fruits and vegetables eaten raw. In this study, we evaluated the associations between a free-living soil nematode, Caenorhabditis elegans, and Escherichia coli, an avirulent strain of Salmonella Typhimurium, Listeria welshimeri, and Bacillus cereus. On an agar medium, young adult worms quickly moved toward colonies of all four bacteria; over 90% of 3-day-old adult worms entered colonies within 16 min after inoculation. After 48 h, worms moved in and out of colonies of L. welshimeri and B. cereus but remained associated with E. coli and Salmonella Typhimurium colonies for at least 96 h. Young adult worms fed on cells of the four bacteria suspended in K medium. Worms survived and reproduced with the use of nutrients derived from all test bacteria, as determined for eggs laid by second-generation worms after culturing for 96 h. Development was slightly slower for worms fed gram-positive bacteria than for worms fed gram-negative bacteria. Worms that fed for 24 h on bacterial lawns formed on tryptic soy agar dispersed bacteria over a 3-h period when they were transferred to a bacteria-free agar surface. The results of this study suggest that C. elegans and perhaps other free-living nematodes are potential vectors for both gram-positive and gram-negative bacteria, including foodborne pathogens in soil. 相似文献
14.
DE Anderson XJ Yuan CM Tseng LJ Rubin GM Rosen ML Tod 《Canadian Metallurgical Quarterly》1993,193(3):878-885
Free radicals react with nitrones to form stable nitroxides which can be identified by ESR spectroscopy. Unfortunately, little is known regarding the pharmacological properties of these compounds. In this study, three commonly used nitrones, 5,5-dimethylpyrroline-N-oxide (DMPO), alpha-phenyl-tert-butylnitrone (PBN), and alpha-(4-pyridyl 1-oxide)-N-tert-butylnitrone (POBN), were found to induce relaxation of preconstricted isolated rat pulmonary artery rings. Additional experiments with PBN indicated that vasorelaxation could not be attributed to production of endothelial derived factors, prostaglandins, or free radicals. Patch-clamp techniques revealed reversible calcium channel blockade with PBN at a concentration below that needed to detect free radicals. Calcium channel blockade probably accounts for the vasorelaxation observed in the isolated ring preparations described here, and should be considered when using nitrone spin-traps both in in vivo and clinical studies. 相似文献
15.
Results from a unique analytical and experimental effort to assess low-altitude, short-range, radar detection capabilities in an evaporation ducting environment are presented. Within the horizon, the duct may shift the location of the last interference null several kilometers in range, which may cause nondetection at ranges where detection is expected and detection at ranges where detection is not expected. In addition, the evaporation duct may reduce the signal strength at ranges near the last interference peak so that detection of low-altitude, small-size, targets may not be possible until the target is much closer. At ranges near and beyond the horizon, radar signal strength depends both on the surface layer and on the mixed layer. To accurately model propagation in this region, knowledge of both surface layer and upper air meteorology Is required. An empirical model to merge the surface layer with the mixed layer has been developed. Comparisons of measured to calculated detection range indicate that the assumption of a standard atmosphere minimizes the variance of the difference between the detection ranges whereas ranges calculated using the measured surface meteorological conditions and a modified surface layer model minimizes the median of the difference 相似文献
16.
The short-range order (SRO) structure of a Au-25 at. pct Fe single crystal was studied using wide-angle diffuse synchrotron
X-radiation scattering at room temperature. Two heat treatments were investigated: a 400 °C aging treatment for 2 days and
a 440 °C treatment for 5 days, both preceded by solution treatment in the single-phase field and water-quenched to room temperature.
Evolution of the SRO structure with aging was determined by fitting the two sets of Cowley-Warren (C-W) SRO parameters to
a pair of 140,608-atom models. The microstructures, although quite disordered, showed a trend with aging for an increasing
volume fraction of an Fe-enriched and an Fe-depleted environment. The Fe-enriched environment displayed a preference for Fe
segregation to the {110} and {100} face-centered cubic (fcc) matrix planes. A major portion of the Fe-depleted environment
was found to contain elements (and variations of these elements) of the Dla ordered superstructure. The SRO contained in the Fe-depleted environment may be best described in terms of the standing concentration
wave packet (SCWP) model. This study provides, for the first time, a quantitative real-space view of the atomic arrangements,
which make up both environments in the SRO structure of Au-25 at. pct Fe.
Formerly Graduate Research Assistant, University of Illinois, Urbana, IL. 相似文献
17.
Huseyin Selcuk Jeosadaque J Sene Marc A Anderson 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2003,78(9):979-984
This study addresses the removal of humic acid (HA) dissolved in an aqueous medium by a photoelectrocatalytic process. UV254 removal and the degradation of color (Vis400) followed pseudo‐first order kinetics. Rate constants were 1.1 × 10?1 min?1, 8.3 × 10?2 min?1 and 2.49 × 10?2 min?1 (R2 > 0.97) for UV254 degradation and 1.7 × 10?1 min?1, 6.5 × 10?2 min?1 and 2.0 × 10?2 min?1 for color removal from 5 mg dm?3, 10 mg dm?3 and 25 mg dm?3 HA respectively. Following a 2 h irradiation time, 96% of the color, 98% of the humic acid and 85% of the total organic carbon (TOC) was removed from an initial 25 mg dm?3 HA solution in the photoanode cell. Photocatalytic removal on the same photoanode was also studied in order to compare the two methods of degradation. Results showed that the photoelectrocatalytic method was much more effective than the photocatalytic method especially at high pH values and with respect to UV254 removal. The effect of other important reaction variables, eg pH, external potential and electrolyte concentration, on the photoelectrocatalytic HA degradation was also studied. Copyright © 2003 Society of Chemical Industry 相似文献
18.
A difficulty in reliability modeling is how to capture the impact of all of the various reliability defect types. The general approach to optimizing burn-in that we describe in this article addresses a multiple-defect environment. The approach has four main parts: (i) modeling the product's failure rate distribution, (ii) establishing the Pareto distribution of reliability defects, (iii) assessing the kinetic information of each reliability defect, and (iv) estimating the DPPM under product use conditions. This article compares and contrasts the acceleration effects of various extrinsic defects found in 130- and 90-nm CMOS technology products. 相似文献
19.
Cara L Booker Jennifer B Unger Stanley P Azen Lourdes Baezconde-Garbanati Brian Lickel C Anderson Johnson 《Nicotine & tobacco research》2007,9(11):1085-1094
The associations between stressful life events and smoking have been established among adolescents in the United States. However, whether these relationships are similar in adolescents from other non-Western cultures is unknown. Understanding these relationships in adolescents may help to provide opportunities to reduce the smoking rates in those cultures by providing positive coping methods that do not include smoking. In this longitudinal study, the associations between nine stressful life events scales and smoking behaviors were examined in a sample of Chinese adolescents. Six of these scales, positive school-related, negative school-related, positive family-related, positive peer-related, negative peer-related, and negative health-related had significantly different means among females and males. Among males, positive school-related stress was a protective factor for smoking susceptibility. Among females, positive school-related stress was a protective factor and negative school-related stress was a risk factor for lifetime smoking, and negative family-related stress was a risk factor for smoking susceptibility. Findings indicate that smoking among male adolescents in China may not be the result of stress; however, in females stress may contribute to the decision to smoke. Future directions are discussed. 相似文献
20.