Synthesis and antitumor activity of novel benzophenone derivatives

Novel benzophenone derivatives were synthesized and screened for cytotoxic and antitumor activity. Friedel-Crafts condensation was employed to construct the benzophenone skeleton. Among the compounds synthesized, morpholino and thiomorpholino benzophenones 3a-d exhibited potent cytotoxic activity against P388 murine leukemia and PC-6 human lung carcinoma cells in vitro, and compounds 3a, 3c, and 3j, when administered intraperitoneally, showed significant antitumor activity against the malignant ascites caused by intraperitoneal inoculation of P388 cells in mice.     

Continuous formation of slurry ice by cooling water–oil emulsion in a tube

Water-silicone oil emulsion with an additive, (C₂H₅O)₃SiC₃H₆NH₂, was examined as a heat storage material. A spiral tube used as a heat exchanger was immersed in a low temperature bath and the emulsion was circulated in the tube to make ice continuously. Ice was separated from the ice–liquid suspension in an outlet tank. The amount of formed ice, the temperatures of the inlet and the outlet of the heat exchanger, and the temperatures in the tube wall were measured and the overall heat transfer coefficient and the heat flux through the tube were calculated. Experiments were carried out, varying the flow rate, the temperature of cooling brine, and the thickness of tube wall. The condition under which slurry ice was formed continuously without adhesion of ice to the cooling wall was clarified. Though decrease in the thermal resistance of the tube increased the rate of ice formation or raised the brine temperature, it narrowed the range of the flow rate and of the brine temperature in which slurry ice was formed continuously.     

A novel gait generation method independent of target settling-time adjustment for underactuated limit cycle walking

This paper proposes a novel gait generation method for surely achieving constraint on impact posture in limit cycle walking. First, we introduce an underactuated rimless wheel model without ankle-joint actuation and formulate a state-space realization of the control output using the stance-leg angle as a time parameter through an input–output linearization. Second, we determine a control input that moves the control output to a terminal value at a target stance-leg angle during the single-support phase. Third, we conduct numerical simulations to observe the fundamental gait properties and discuss the relationship between the gait symmetry and mechanical energy restoration. Furthermore, we mathematically prove the asymptotic stability of the generated walking gait by analytically deriving the restored mechanical energy.     

High-performance cone beam reconstruction using CUDA compatible GPUs

Compute unified device architecture (CUDA) is a software development platform that allows us to run C-like programs on the nVIDIA graphics processing unit (GPU). This paper presents an acceleration method for cone beam reconstruction using CUDA compatible GPUs. The proposed method accelerates the Feldkamp, Davis, and Kress (FDK) algorithm using three techniques: (1) off-chip memory access reduction for saving the memory bandwidth; (2) loop unrolling for hiding the memory latency; and (3) multithreading for exploiting multiple GPUs. We describe how these techniques can be incorporated into the reconstruction code. We also show an analytical model to understand the reconstruction performance on multi-GPU environments. Experimental results show that the proposed method runs at 83% of the theoretical memory bandwidth, achieving a throughput of 64.3 projections per second (pps) for reconstruction of 512³-voxel volume from 360 512²-pixel projections. This performance is 41% higher than the previous CUDA-based method and is 24 times faster than a CPU-based method optimized by vector intrinsics. Some detailed analyses are also presented to understand how effectively the acceleration techniques increase the reconstruction performance of a naive method. We also demonstrate out-of-core reconstruction for large-scale datasets, up to 1024³-voxel volume.     

Dynamics of absorbed water in model composites of polyamide 6 and carbon fibre evaluated by differential scanning calorimetry

The crystallization and subsequent melting behaviour of absorbed water in the model composites of polyamide 6 (PA6) and carbon fibre were investigated by differential scanning calorimetry (DSC) in comparison with those in neat PA6, using the small rectangular specimens exposed to water at 90 °C. In the DSC curves of PA6 any exothermic peaks of crystallization and endothermic ones of melting were not observed, but a step corresponding to glass transition was observed at about −30 °C during the heating process. Thus water absorbed by neat PA6 was recognized as non-freezing bound water which does not crystallize, probably due to the strong interaction with the polyamide chains. On the other hand, for the model composite several exothermic peaks were clearly observed at temperatures ranging from −10 to −20 °C, and their intensity was increased with increasing the fibre content. The distinct endothermic peaks were detected around at 0 °C during the reversed heating process. The glass transition temperature was not affected by adding the carbon fibre. Comparing with the result of neat PA6 indicates that in the model composite water exists in a state near free water, besides the non-freezing bound water dispersed in the matrix polyamide. It is further implied that water is mainly accumulated in the matrix/fibre interfacial region with some microstructural heterogeneties or defects, in which the water molecules can easily move under much weaker interaction with the polyamide chains.     

Study on high performance ice slurry formed by cooling emulsion in ice storage (discussion on adaptability of emulsion to thermal storage material)

This study focuses on an emulsion as a new thermal storage material for ice storage. Two types of emulsions were formed using an oil–water mixture with a small amount of additive. A silicone, light and lump oils were used. The water contents of the emulsions were 70, 80 and 90%. The additive was an amino group modified silicone oil. No depression of freezing point was observed for the emulsions because of their hydrophobic properties. In order to determine the structure of the emulsions, their electrical resistances were measured. Moreover, components of the liquids separating from the emulsions were analyzed. The results indicated that one emulsion was a W/O type emulsion, while the other was an O/W type. Finally, adaptability of the two emulsions to ice storage was discussed, it was concluded that a high performance ice slurry could be formed by the W/O type emulsion.     

Chemical vapor deposition of SiO2 films by TEOS/O2 supermagnetron plasma

A TEOS/O₂ supermagnetron double electrode plasma system was used to deposit SiO₂ films. Deposition rates were measured as a function of rf power and substrate stage temperature. With an increase of rf power on both electrodes from 40 to 80W, the deposition rate increased; however, with a further increase of rf power from 80 to 120W, the deposition rate ceased to increase or decreased only a small amount. The presence of O-H bonds from bonded water in the film was evaluated using buffered HF (BHF) etching solution. With an increase of rf power from 40 to 120W, the BHF etch rate decreased; i.e., the number of O-H bonds were reduced. A minimum BHF etch rate was observed at a rf phase difference of 180° between the two rf power sources. A SiO₂ film was deposited on a trench-patterned quartz substrate. A flat surface SiO₂ layer with air gaps (voids) was formed on the high-aspect ratio (depth/width=1.5-2) trench area.