Recognition is not parsing — SPPF-style parsing from cubic recognisers

In their recogniser forms, the Earley and RIGLR algorithms for testing whether a string can be derived from a grammar are worst-case cubic on general context free grammars (CFG). Earley gave an outline of a method for turning his recognisers into parsers, but it turns out that this method is incorrect. Tomita’s GLR parser returns a shared packed parse forest (SPPF) representation of all derivations of a given string from a given CFG but is worst-case unbounded polynomial order. The parser version of the RIGLR algorithm constructs Tomita-style SPPFs and thus is also worst-case unbounded polynomial order. We have given a modified worst-case cubic GLR algorithm, that, for any string and any CFG, returns a binarised SPPF representation of all possible derivations of a given string. In this paper we apply similar techniques to develop worst-case cubic Earley and RIGLR parsing algorithms.     

Characterization of expression of a plant oleate desaturase in yeast

We have expressed the oleate desaturase gene of Arabidopsis thaliana in Saccharomyces cerevisiae by means of a galactose-inducible promoter. Transfer of yeast cells to galactose-containing media and growth at 30°C resulted in the production of active oleate desaturase, as shown by the appearance of the diunsaturated octadecadienoic acid (18:2) and hexadecadienoic acid (16:2). The highest level of these two fatty acids was 46.2%. In induced cultures, 18:2 appeared before 16:2, and we show that both of these fatty acids were present first on phosphatidylcholine and then appeared in other phospholipids and a neutral lipid fraction. We raised antibodies against the C-terminal 100 amino acids of oleate desaturase and demonstrated that this protein was in the microsomal fraction of induced cells.     

Islet amyloid polypeptide in patients with pancreatic cancer and diabetes

Population-based psychiatric admission rates vary across geographic areas, but reasons for this variation are unknown. Insofar as Community Mental Health Centers (CMHCs) provide outpatient services that may deter the need for hospitalization, the presence and structural characteristics of CMHCs may have an impact on a population's psychiatric admission rates. This study uses small area analysis to examine how general hospital psychiatric admission rates are associated with CMHC characteristics. Based on a survey of all CMHCs in Iowa and corresponding small area variation data, it was found that population admission rates were higher in areas closer to the CMHC and lower in outlying catchment areas, adjusting for age, sex, and urban/rural differences in populations. There was little evidence that differences in staffing and service variables influenced admission rates, although greater CMHC staff coverage by social workers and psychiatric residents was associated with lower admission rates. The results suggest that CMHCs do not lower an area's hospitalization rate, and in fact, the presence of CMHCs may promote a "supplier-induced demand" phenomenon of higher admissions.     

Situvis: A sensor data analysis and abstraction tool for pervasive computing systems

Pervasive systems are large-scale systems consisting of many sensors capturing numerous types of information. As this data is highly voluminous and dimensional, data analysis tasks can be extremely cumbersome and time-consuming. Enabling computers to recognise real-world situations is an even more difficult problem, involving not only data analysis, but also consistency checking. Here we present Situvis, an interactive visualisation tool for representing sensor data and creating higher-level abstractions from the data. This paper builds on previous work, Clear et al. (2009) [8] through evolved tool functionality and an evaluation of Situvis. A user-trial consisting of 10 participants shows that Situvis can be used to complete the key tasks in the development process of situation specifications in over 50% less time than an improvised alternative toolset.     

密封装置有效热管理的散热解决方案

由于密封装置中缺乏有效的热管理,将不可避免地导致温度上升至极点,从而损坏电气设备。热量在密封装置中迅速累积,如果不采取其他措施,热量只能经由密封装置的外壳,以辐射和对流的形式缓慢地向外散发。     

The reliability of a segmentation methodology for assessing intramuscular adipose tissue and other soft-tissue compartments of lower leg MRI images

Objective

Determine the reliability of a magnetic resonance (MR) image segmentation protocol for quantifying intramuscular adipose tissue (IntraMAT), subcutaneous adipose tissue, total muscle and intermuscular adipose tissue (InterMAT) of the lower leg.

Materials and methods

Ten axial lower leg MRI slices were obtained from 21 postmenopausal women using a 1 Tesla peripheral MRI system. Images were analyzed using sliceOmatic? software. The average cross-sectional areas of the tissues were computed for the ten slices. Intra-rater and inter-rater reliability were determined and expressed as the standard error of measurement (SEM) (absolute reliability) and intraclass coefficient (ICC) (relative reliability).

Results

Intra-rater and inter-rater reliability for IntraMAT were 0.991 (95 % confidence interval [CI] 0.978–0.996, p < 0.05) and 0.983 (95 % CI 0.958–9.993, p < 0.05), respectively. For the other soft tissue compartments, the ICCs were all >0.90 (p < 0.05). The absolute intra-rater and inter-rater reliability (expressed as SEM) for segmenting IntraMAT were 22.19 mm² (95 % CI 16.97–32.04) and 78.89 mm² (95 % CI 60.36–113.92), respectively.

Conclusion

This is a reliable segmentation protocol for quantifying IntraMAT and other soft-tissue compartments of the lower leg. A standard operating procedure manual is provided to assist users, and SEM values can be used to estimate sample size and determine confidence in repeated measurements in future research.

     

Selective Targeting of Human and Animal Pathogens of the Helicobacter Genus by Flavodoxin Inhibitors: Efficacy,Synergy, Resistance and Mechanistic Studies

Antimicrobial resistant (AMR) bacteria constitute a global health concern. Helicobacter pylori is a Gram-negative bacterium that infects about half of the human population and is a major cause of peptic ulcer disease and gastric cancer. Increasing resistance to triple and quadruple H. pylori eradication therapies poses great challenges and urges the development of novel, ideally narrow spectrum, antimicrobials targeting H. pylori. Here, we describe the antimicrobial spectrum of a family of nitrobenzoxadiazol-based antimicrobials initially discovered as inhibitors of flavodoxin: an essential H. pylori protein. Two groups of inhibitors are described. One group is formed by narrow-spectrum compounds, highly specific for H. pylori, but ineffective against enterohepatic Helicobacter species and other Gram-negative or Gram-positive bacteria. The second group includes extended-spectrum antimicrobials additionally targeting Gram-positive bacteria, the Gram-negative Campylobacter jejuni, and most Helicobacter species, but not affecting other Gram-negative pathogens. To identify the binding site of the inhibitors in the flavodoxin structure, several H. pylori-flavodoxin variants have been engineered and tested using isothermal titration calorimetry. An initial study of the inhibitors capacity to generate resistances and of their synergism with antimicrobials commonly used in H. pylori eradication therapies is described. The narrow-spectrum inhibitors, which are expected to affect the microbiota less dramatically than current antimicrobial drugs, offer an opportunity to develop new and specific H. pylori eradication combinations to deal with AMR in H. pylori. On the other hand, the extended-spectrum inhibitors constitute a new family of promising antimicrobials, with a potential use against AMR Gram-positive bacterial pathogens.     

Optimization and evaluation of reduced graphene oxide hydrogel composite as a demulsifier for heavy crude oil-in-water emulsion

The rising production of produced water from oilfields had been proven to bring detrimental environmental effects. In this study, an efficient, recyclable, and environmental-friendly reduced graphene oxide immobilized κ-Carrageenan hydrogel composite(κCa GO) was fabricated as an alternative sorbent for crude oil-in-water demulsification. Polyethyleneimine(PEI) was employed to form a stable hydrogel composite. The conditions for the immobilization of graphene oxide(GO) on PEI-modified κ-Carrageenan(κC) beads were optimized appropriately. An immobilization yield of 77% was attained at 2% PEI, 2 h immobilization activation time, and p H6.5. Moreover, the synthesized κCa GO is capable of demulsification with an average demulsification efficiency of 70%. It was found that the demulsification efficiency increases with salinity and κCa GO dosage, and it deteriorates under alkaline condition. These phenomena can be attributed to the interfacial interactions between κCa GO and the emulsion. Furthermore, the κCa GO can be recycled to use for up to six cycles without significant leaching and degradation. As such, the synthesized κCa GO could be further developed as a potential sorbent substitute for the separation of crude oil from produced water.     

Infrared-to-ultraviolet light-absorbing BaTiO3-based ferroelectric photovoltaic materials

Ferroelectric oxides have been demonstrated to be promising in developing emerging photovoltaic technologies because of the various mechanisms that allow above-band-gap photovoltages and higher efficiencies. However, the wide band gaps of conventional ferroelectric oxides (2.7-4 eV) limit their utilization of the solar spectrum. Here the phase stability, absorption properties, ferroelectric, and photovoltaic responses of Ni- and Ni-Nb-substituted BaTiO₃ were explored to evaluate their potential as visible-light-absorbing photovoltaic materials. Although the acceptor substitution of Ni²⁺ stabilized a hexagonal 6H polymorph in both systems, post-annealing treatments allowed restoration of a tetragonal 3C phase for Ba(Ti_0.99Ni_0.01)O_2.99 and (0.9)BaTiO₃-(0.1)Ba(Ni_1/2Nb_1/2)O_2.75. The oxygen vacancies accompanying the Ni and Ni-Nb substitutions significantly lower the optical band gap of BaTiO₃ to ~1.5 eV and the visible light absorption can be systematically tuned between 380 and 1000 nm by varying the Ni:Nb ratio. Room temperature ferroelectricity was observed in Ba(Ti_0.99Ni_0.01)O_2.99 with a saturation polarization = 18 μC/cm² and remnant polarization = 1 μC/cm². The Ni-Nb substituted composition (0.9)BaTiO₃-(0.1)Ba(Ni_1/2Nb_1/2)O_2.75 shows a ferroelectric response with a remnant polarization of 5 μC/cm² at 77 K, which gradually decreases as temperature increases. Both compositions exhibit ferroelectrically switchable photoresponses under an AM 1.5 G sunlight simulator; the highest switchable steady-state current of 8 nA/cm² observed for (0.9)BaTiO₃-(0.1)Ba(Ni_1/2Nb_1/2)O_2.75 exceeds those reported in previous studies of BaTiO₃ ceramic samples (J Solid State Chem, 1975; 12: 193; Jpn J Appl Phys, 2013; 52: 09KF03).