Aerodynamic response of structures with parametric uncertainties

Uncertainties associated with the load effects and dynamic characteristics of wind-excited structures have been identified and discussed. Based on the available experimental data from laboratory and field study measurements the variability of the parameter space categorized as wind environment and meteorological data, wind-structure interaction and structural properties has been assessed. The probabilistic dynamic response of a wind-excited structyre has been expressed in terms of uncertain parameters. The influence of uncertainty in these parameters has been propagated in accordance with the functional relationships that relate them to the structural response. In this study, the propagation of uncertainty has been obtained by employing the Second-Moment and Monte Carlo simulation techniques. The dynamic response of a chimney subjected to aerodynamic loads is presented to illustrate the treatment of uncertainty in the parameter space. The mean and coefficient of variation of the peak chimney response, in terms of top deflections and associated base bending moments, exhibit close agreement between the Second-Moment and simulation techniques. A sensitivity analysis has been conducted which delineates the relative significance of uncertainty in the several parameters, related to both load effects and structural characteristics, on the overall uncertainty in the aerodynamic response of a chimney. The uncertainty associated with both response components suggests a need for further improvement in the modeling of wind-structure interaction, prediction of natural frequencies and damping, and reduction in the variability of extreme wind estimates. There are immediate applications of the procedures discussed in this paper for a variety of wind-sensitive structures.     

Disproportionation of Q m (0 ≤ m ≤ 4) species in partially devitrified Li2Si2O5 glasses with small amounts of P2O5

The effect of addition of small amounts of P₂O₅ in the lithium disilicate glasses results in the scavenging of lithium metal ions by a phosphate group, Li₃PO₄. As a consequence of the scavenging, the silicate network partially repolymerises. The phosphate group remains intact during heat treatment of the optically clear, X-ray amorphous and slightly nucleated base glasses. However, the relative amounts of the silicate species, Q_m (0 ≤ m ≤ 4), are dependent on the state of the glasses. These amounts, in the optically clear and X-ray amorphous, do not change with heat treatment but they do change, i.e. disproportionation occurs in the slightly nucleated and milky coloured glasses. The disproportionation follows the relation 2Q₃ → Q₂ + Q₄ which is evident from the relative intensity of the different peaks.     

Short Communication: Some Photophysical Properties of Nanotubes

The absorption spectra of (10,10) nanotubes are reported at varying concentrations. In addition, we have found that nanotubes are unable to photosensitize formation of singlet oxygen (¹O₂) and do not significantly quench it. These results imply that nanotubes are not able to form long-lived or localized excited states.     

Aeroelastic Analysis of Bridges under Multicorrelated Winds: Integrated State-Space Approach

In this paper, an integrated state-space model of a system with a vector-valued white noise input is presented to describe the dynamic response of bridges under the action of multicorrelated winds. Such a unified model has not been developed before due to a number of innate modeling difficulties. The integrated state-space model is realized based on the state-space models of multicorrelated wind fluctuations, unsteady buffeting and self-excited aerodynamic forces, and the bridge dynamics. Both the equations of motion at the full order in the physical coordinates and at the reduced-order in the generalized modal coordinates are presented. This state-space model allows direct evaluation of the covariance matrix of the response using the Lyapunov equation, which presents higher computational efficiency than the conventional spectral analysis approach. This state-space model also adds time domain simulation of multicorrelated wind fluctuations, the associated unsteady frequency dependent aerodynamic forces, and the attendant motions of the structure. The structural and aerodynamic coupling effects among structural modes can be easily included in the analysis. The model also facilitates consideration of various nonlinearities of both structural and aerodynamic origins in the response analysis. An application of this approach to a long-span cable-stayed bridge illustrates the effectiveness of this scheme for a linear problem. An extension of the proposed analysis framework to include structural and aerodynamic nonlinearities is immediate once the nonlinear structural and aerodynamic characteristics of the bridge are established.     

Damping estimation using enhanced virtual dynamic shaker: A web‐enabled framework

Damping estimation from laboratory, full‐scale, or computational simulation is critical in response prediction of structures under wind, waves, or earthquake effects. A virtual dynamic shaker (VDS)‐based scheme was recently developed for system identification (SI) of structures for processing (weakly) stationary responses, that is, frequency and damping features that offers, especially the added advantage of its basic simplicity over other schemes. While the VDS has shown performance, equivalent to other popular SI schemes, it is based on the assumption of the global flatness of the load spectrum (i.e., white noise assumption) like used in most other SI schemes, which may not always be appropriate in practical applications. In addition, it is restricted to data from a single‐degree‐of‐freedom (SDOF) response (or unimodal response) to obtain accurate modal characteristics. To address these potential shortcomings, this study revisits the VDS scheme and offers an enhancement by invoking local flatness assumption (EVDS) to possibly improve the damping estimation with the assumption that the load spectrum is flat only around the natural frequencies of the desired modes. A new formulation involving the effect of the ground motion induced vertical vibrations of a building is also introduced for both the VDS and the EVDS. Extensive examples through numerical simulation and full‐scale data, including a comparison with other popular SI schemes, demonstrate the efficacy of the proposed EVDS scheme. To facilitate expeditious and convenient utilization of the proposed EVDS as well as the VDS, this study has implemented a web‐enabled framework, named VDS‐Damping, for on‐demand and on‐the‐fly applications through user‐friendly input and result interfaces. A recently developed mode decomposition scheme, state space‐based mode decomposition (SSBMD), is implemented in the framework to assist in analyzing output from multiple modes and eliminates restriction of SDOF system. Accordingly, the SSBMD can also serve as a stand‐alone mode decomposition tool to separate response in each mode. This framework enables users to estimate damping on‐the‐fly by uploading with ease their data.     

Porous structures fabrication by continuous and pulsed laser metal deposition for biomedical applications; modelling and experimental investigation

The use of porous surface structures is gaining popularity in biomedical implant manufacture due to its ability to promote increased osseointegration and cell proliferation. Laser direct metal deposition (LDMD) is a rapid manufacturing technique capable of producing such a structure. In this work LDMD with a diode laser in continuous mode and with a CO₂ laser in pulsed modes are used to produce multi-layer porous structures. Gas-atomized Ti-6Al-4V and 316L stainless steel powders are used as the deposition material. The porous structures are compared with respect to their internal geometry, pore size, and part density using a range of techniques including micro-tomography. Results show that the two methods produce radically different internal structures, but in both cases a range of part densities can be produced by varying process parameters such as laser power and powder mass flow rate. Prudent selection of these parameters allows the interconnected pores that are considered most suitable for promoting osseointegration to be obtained. Analytical models of the processes are also developed by using Wolfram Mathematica software to solve interacting, transient heat, temperature and mass flow models. Measured and modelled results are compared and show good agreement.     

Enhanced stability and permeation potential of nanoemulsion containing sefsol-218 oil for topical delivery of amphotericin B

Aim: To characterize the enhanced stability and permeation potential of amphotericin B nanoemulsion comprising sefsol-218 oil at varying pH and temperature of aqueous continuous phase.

Methodology: Several batches of amphotericin B loaded nanoemulsion were prepared and evaluated for their physical and chemical stability at different pH and temperature. Also, a comparative study of ex vivo drug permeation across the albino rat skin was investigated with commercial Fungisome® and drug solution at 37?°C for 24?h. The extent of drug penetrated through the rat skin was thereby evaluated using the confocal laser scanning microscopy (CLSM).

Results and conclusions: The optimized nanoemulsion demonstrated the highest flux rate 17.85?±?0.5?µg/cm²/h than drug solution (5.37?±?0.01?µg/cm²/h) and Fungisome® (7.97?±?0.01?µg/cm²/h). Ex vivo drug penetration mechanism from the developed formulations at pH 6.8 and pH 7.4 of aqueous phase pH using the CLSM revealed enhanced penetration. Ex vivo drug penetration studies of developed formulation comprising of CLSM revealed enhanced penetration in aqueous phase at pH 6.8 and 7.4. The aggregation behavior of nanoemulsion at both the pH was found to be minimum and non-nephrotoxic. The stability of amphotericin B was obtained in terms of pH, optical density, globular size, polydispersity index and zeta potential value at different temperature for 90 days. The slowest drug degradation was observed in aqueous phase at pH 7.4 with shelf life 20.03-folds higher when stored at 4?°C (3.8 years) and 5-fold higher at 25?°C (0.951 years) than at 40?°C. The combined results suggested that nanoemulsion may hold an alternative for enhanced and sustained topical delivery system for amphotericin B.     

Esophageal Squamous Cancer from 4NQO-Induced Mice Model: CNV Alterations

Squamous esophageal carcinoma is a common pathological type of esophageal carcinoma around the world. The prognosis of esophageal carcinoma is usually poor and diagnosed at late stages. Recently, research suggested that genomic instability occurred in esophageal cells during the development of esophageal squamous cell carcinoma (ESCC). Identifying prognostic and specific genomic characteristics, especially at the early hyperplasia stage, is critical. Mice were given 4-nitroquinoline 1-oxide (4NQO) with drinking water to induce esophageal cancer. The immortalized human esophageal epithelial cell line (NE2) was also treated with 4NQO. We performed histologic analyses, immunofluorescence, and immunohistochemical staining to detect DNA damage at different time points. Whole-exome sequencing was accomplished on the esophagus tissues at different pathological stages to detect single-nucleotide variants and copy number variation (CNV) in the genome. Our findings indicate that all mice were tumor-forming, and a series of changes from simple hyperplasia (ESSH) to intraepithelial neoplasia (IEN) to esophageal squamous cell carcinoma (ESCC) was seen at different times. The expression of γ-H2AX increased from ESSH to ESCC. In addition, mutations of the Muc4 gene were detected throughout the pathological stages. Furthermore, CNV burden appeared in the esophageal tissues from the beginning of ESSH and accumulated more in cancer with the deepening of the lesions. This study demonstrates that mutations caused by the early appearance of DNA damage may appear in the early stage of malignant tissue before the emergence of atypia. The detection of CNV and mutations of the Muc4 gene may be used as an ultra-early screening indicator for esophageal cancer.