Disaster-survivable cloud-network mapping

Cloud-computing services are provided to consumers through a network of servers and network equipment. Cloud-network (CN) providers virtualize resources [e.g., virtual machine (VM) and virtual network (VN)] for efficient and secure resource allocation. Disasters are one of the worst threats for CNs as they can cause massive disruptions and CN disconnection. A disaster may also induce post-disaster correlated, cascading failures which can disconnect more CNs. Survivable virtual-network embedding (SVNE) approaches have been studied to protect VNs against single physical-link/-node and dual physical-link failures in communication infrastructure, but massive disruptions due to a disaster and their consequences can make SVNE approaches insufficient to guarantee cloud-computing survivability. In this work, we study the problem of survivable CN mapping from disaster. We consider risk assessment, VM backup location, and post-disaster survivability to reduce the risk of failure and probability of CN disconnection and the penalty paid by operators due to loss of capacity. We formulate the proposed approach as an integer linear program and study two scenarios: a natural disaster, e.g., earthquake and a human-made disaster, e.g., weapons-of-mass-destruction attack. Our illustrative examples show that our approach reduces the risk of CN disconnection and penalty up to 90 % compared with a baseline CN mapping approach and increases the CN survivability up to 100 % in both scenarios.     

Design of RF MEMS Based Oscillatory Neural Network for Ultra High Speed Associative Memories

Microelectromechanical systems are utilized alongside with transistor amplifiers and resistive connections for implementing of oscillatory associative memories. Phase locking is studied in such a network and all requirements of the circuit level implementation are satisfied. A very high gain trans-impedance amplifier operating in 1 GHz in addition to a novel automatic amplitude control circuit is employed to remove amplitude dynamics of the system. Requiring resonator characteristics are extracted and calculated as well. A new method for initialization of the network is proposed. Each neuron consumes 1.08 mW from a 1.8 V power supply. The convergence time of a typical network trained by Hebbian rule is less than 1.5 ns which results in an ultra high speed analog signal processing system.     

Heart rate variability in low birth weight growth restricted children during sleep and wake stages

Intrauterine growth restricted (IUGR) individuals have greater predisposition to develop a metabolic syndrome in later life manifesting itself as obesity, hypertension, type 2 diabetes or cardiovascular disease. Poor fetal growth may alter the regularity mechanism of cardiac autonomic system that is involved in the development of these diseases. The malfunctioning of the cardiac autonomic system assessed by decrease in heart rate variability (HRV) is associated with negative cardiovascular outcomes. This study is aimed at investigating the risk of development of coronary heart disease in IUGR children in later life. For that purpose HRV analysis of normal and growth restricted children was performed during sleep and wake stages. The study group consisted of 9–10 years old, 32 normal, 20 low birth weight IUGR children. The standard time domain HRV metrics (mean RR, SDNN, RMSSD, NN50 and pNN50) and Poincaré indices (SD₁ and SD₂) were used to analyse and compare the RR-interval time series of these groups. The IUGR children showed lower HRV as compared with normal children during both sleep and wake stages. The significantly decreased HRV during sleep provide an evidence of autonomic derangement that may be associated with higher risk of lethal arrhythmias in the IUGR children in later life.     

Load management: impacts on the reliability and production costs of interconnected systems

With the increasing recognition that load management could be beneficial to a utility, the planner has an added alternative in generation expansion planning in deciding whether to construct a new plant, to purchase power from a neighbouring utility or to implement a load management scheme. This paper evaluates the impacts of load management strategies on the reliability as well as on the production costs of two interconnected systems. Investigation has been made to find the equivalence, in terms of reliability improvement and production cost benefit, between the tie-line capacity and the percentage reduction of the peak demand. In the simulation, the correlation between the loads of two inteconnected systems is considered. The segmentation method is utilized in the numerical simulation.     

The advanced set-up and control system for Dofasco's tandem coldmill

The new coupled pickle line and cold mill (CPCM) has been processing steel since December 1991 at Dofasco Inc. in Hamilton, Ontario, Canada. This mill rolls both sheet and tin plate. The work rolls for the last stand are often textured by grit blasting to roll “matte” finished strip. A new computer-targeted control system was developed for the roll speeds and gaps, specifically for matte rolling. The new set-up system uses Stone's model, which is more appropriate for the limited reductions evident with the rougher rolls. Conventional automatic gauge control (AGC) systems using thickness measurements after the last stand are limited in performance by the effect of long transport delays. These limitations are particularly critical during mill acceleration and deceleration. The use of a thickness gauge before the stand with matte rolls allows the development of AGC systems using shorter control loops for final gauge control. The AGC system uses a Smith predictor for transport lag, (phase shift), and compensation. The combination of the shorter AGC loop and the Smith predictor allows higher gains to be used in the control system. This set-up and control system has contributed to Dofasco's position as a market leader in thickness performance     

ECG anomalies and axis deviations in heart transplant recipients: MRI studies]

Side effects of morphine are common when given in titrated doses to control severe pain in advanced cancer. We report a case series of acutely ill cancer patients suffering from pain, complications of advanced disease, and opioid side effects. They were treated with intravenous (i.v.) ketorolac along with i.v. morphine using repeated dosing. Excellent pain relief with improvement in the opioid bowel syndrome was achieved. We found it possible to switch from IV ketorolac to oral ketorolac along with oral morphine for long-term pain control. Ketorolac can be well tolerated in high-dose, long-term use even in this frail patient population. An algorithm is presented for the suggested use of ketorolac as a morphine sparing agent. Potential methods for studying ketorolac further in this role are discussed.     

Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein

Antibodies raised against the 51C/SHIP2 inositol polyphosphate 5'-phosphatase were used to examine the effects of growth factors and insulin on the metabolism of this protein. Immunoblot analysis revealed that the 51C/SHIP2 protein was widely expressed in fibroblast and nonhematopoietic tumor cell lines, unlike the SHIP protein, which was found only in cell lines of hematopoietic origin. The 51C/SHIP2 antiserum precipitated a protein of approximately 145 kDa along with an activity which hydrolyzed phosphatidylinositol 3,4, 5-trisphosphate to phosphatidylinositol 3,4-bisphosphate. Tyrosine phosphorylation of the 51C/SHIP2 protein occurred in response to treatment of cells with epidermal growth (EGF), platelet-derived growth factor (PDGF), nerve growth factor (NGF), insulin-like growth factor-1 (IGF-1), or insulin. EGF and PDGF induced transient tyrosine phosphorylation of 51C/SHIP2, with maximal tyrosine phosphorylation occurring at 5-10 min following treatment and returning to near basal levels within 20 min. In contrast, treatment of cells with NGF, IGF-1, or insulin resulted in prolonged tyrosine phosphorylation of 51C/SHIP2 protein, with 40-80% maximal phosphorylation sustained for up to 2 h following agonist treatment. The kinetics of activation of the Akt/PKB protein kinase by the various factors correlated well with the kinetics of tyrosine phosphorylation of 51C/SHIP2. EGF, NGF, and PDGF stimulated the association of 51C/SHIP2 protein with the Shc adapter protein; however, no Shc could be detected in 51C/SHIP2-immune precipitates from cells treated with IGF-1 or insulin. The data suggest that 51C/SHIP2 may play a significant role in regulation of phosphatidylinositol 3'-kinase signaling by growth factors and insulin.     

Talbot imaging and unification

The fractional Talbot effect brings into play a superimposition of shifted and complex weightedreplicas of the original object. This phenomenon can be used to replicate images of nonperiodic objects by means of Talbot array illuminators. These diffractive elements can also be used to concentrate replicas into a single image. These techniques are useful for several applications such as beam shaping.     

Characterization of a thermostable family 10 endo-xylanase (XynB) from Thermotoga maritima that cleaves p-nitrophenyl-beta-D-xyloside

Thermotoga maritima MSB8 possesses two xylanase genes, xynA and xynB. The xynB gene was isolated from the genomic DNA of T. maritima, cloned, and expressed in Escherichia coli. XynB was purified to homogeneity by heat treatment, affinity chromatography and ion-exchange column chromatography. The purified enzyme produced a single band upon SDS-PAGE corresponding to a molecular mass of 42 kDa. At 70 degrees C, the enzyme was stable between pH 5.0 and pH 11.4, and it was stable at temperatures of up to 100 degrees C from pH 7.0 to pH 8.5. At 50 degrees C, XynB displayed an optimum pH of 6.14 and at this pH the temperature for optimal enzyme activity was 90 degrees C. XynB exhibited broad substrate specificity and was highly active towards p-nitrophenyl-beta-D-xylobioside with K(m) and k(cat) values of 0.0077 mM and 5.5 s(-1), respectively, at 30 degrees C. It was also active towards p-nitrophenyl-beta-D-xyloside. The initial product of the cleavage of p-nitrophenyl-beta-D-xyloside was xylobiose, indicating that the major reaction in the cleavage was transglycosylation, not hydrolysis.