PCN-Fe(III)-PTX nanoparticles for MRI guided high efficiency chemo-photodynamic therapy in pancreatic cancer through alleviating tumor hypoxia

As nanomedicine-based clinical strategies have continued to develop, the possibility of combining chemotherapy and singlet oxygen-dependent photodynamic therapy (PDT) to treat pancreatic cancer (PaC) has emerged as a viable therapeutic modality. The efficacy of such an approach, however, is likely to be constrained by the mechanisms of drug release and tumor oxygen levels. In the present study, we developed an Fe(III)-complexed porous coordination network (PCN) which we then used to encapsulate PTX (PCN-Fe(III)-PTX) nanoparticles (NPs) in order to treat PaC via a combination of chemotherapy and PDT. The resultant NPs were able to release drug in response to both laser irradiation and pH changes to promote drug accumulation within tumors. Furthermore, through a Fe(III)-based Fenton-like reaction these NPs were able to convert H₂O₂ in the tumor site to O₂, thereby regulating local hypoxic conditions and enhancing the efficacy of PDT approaches. Also these NPs were suitable for use as a T₁-MRI weighted contrast agent, making them viable for monitoring therapeutic efficacy upon treatment. Our results in both cell line and animal models of PaC suggest that these NPs represent an ideal agent for mediating effective MRI-guided chemotherapy-PDT, giving them great promise for the clinical treatment of PaC.

     

燃烧室容积多微机测控系统

分析了Ｇ４２７发动机抽盖在生产过程中存在的问题及解决的方法和步骤，详细介绍了ＧＧＣＡＭ－１分布式多微机系统各部分的组成及工作管理，通信网络结构与通信控制。实际作用表明，该系统结构简单，运行可靠，且具有较高的性能价值比。     

In-situ observation and relocation method of nanomaterial samples based on microscope systems

Taking poly(lactic acid) microbubbles and purple membranes as examples, a general in situ observation and relocation method of nanomaterial samples based on microscope systems was reported. First, a four-grade coordinate with different precisions was marked around a substrate by UV lithography. Second, using optical microscope and scanning probe microscope, special positions of poly(lactic acid) microbubbles and purple membranes were observed, respectively. Third, the four-grade coordinate value corresponded to the special sample position, and the distance between the special position and coordinate edge were recorded, respectively. Finally, the special position can be easily found again, or the sample in the special position can be manipulated and secondary processed based on the recorded coordinate value and distance, after the sample was removed and then was reset on the sample stage of microscope. The in situ observation and relocation method can be applied in different microscope systems and different sample substrates, and will have potential applications in the manipulation and the secondary process of micro- and nano-devices.     

超宽带SAR虚假图像干扰技术

为了对低频超宽带合成孔径雷达(SAR)实施有效的图像欺骗干扰,提出基于卷积技术的欺骗干扰方法。基于SAR目标回波特性,推导了干扰调制函数解析式。在产生干扰信号时,需要对解析式进行近似处理,针对低频超宽带SAR二维强耦合特性以及超宽带SAR成像处理算法,将干扰调制函数精确到三次相位项,并对各级系数进行分析和简化处理。最后通过仿真实例验证了对干扰产生函数改进的必要性及干扰的有效性。理论分析和仿真结果均表明,改进后的干扰方法可以对超宽带SAR实施有效的图像欺骗干扰。     

行波型球形超声电机定子的优化设计

提出了一种具有同步调心结构的球形超声电机,建立了电机驱动力矩的数学模型,重点对行波型定子进行结构优化设计。利用ANSYS对定子进行模态分析和谐响应分析;通过灵敏度分析确定结构参数优化变量,以最大干扰模态与工作模态频率差和最大定子表面振幅为优化目标,建立设计空间的响应面模型,采用多目标遗传算法(MOGA)进行优化求解得到Pareto前沿,最终确定结构参数并对定子试制件进行定扫频实验。测试结果表明,优化后的定子工作模态频率±2 kHz内无干扰模态产生,且定子两相驻波表面质点具有较大振幅,满足使用要求。     

再生粗骨料的形态及缺陷对再生混凝土干燥收缩和力学性能的影响

本工作分析了三种不同工艺制备的再生粗骨料的形态、附着砂浆及界面区显微硬度,研究了骨料形态和缺陷对其干燥收缩和力学性能的影响,最后结合骨料的释水效应、显微硬度和断裂形态,探讨了不同工艺制备的再生骨料引起的缺陷差异及其对再生混凝土干燥收缩和力学性能的影响机理.结果表明:相对颚式破碎,反击式破碎制备的骨料的粒形较好,针片状较少,骨料表面附着的水泥浆体显著减少,采用圆盘整形工艺则可以进一步提高颗粒的粒形,减少骨料表面附着的砂浆.再生骨料中含有的砂浆导致其吸水率较高,具有一定的内养护作用,能够降低其早期收缩,但后期水分的蒸发仍会导致再生混凝土的干缩增大.反击式破碎制备的再生骨料(RA-C1)界面显微硬度高于颚式破碎制备的再生骨料(RA-E),且以其制备的混凝土的强度也大于RA-E组;反击式破碎+整形制备的再生骨料(RA-C2)虽然界面性能最好,但由于骨料强度不高导致其力学性能相对较低.     

Record‐High Superconductivity in Niobium–Titanium Alloy

The extraordinary superconductivity has been observed in a pressurized commercial niobium–titanium alloy. Its zero‐resistance superconductivity persists from ambient pressure to the pressure as high as 261.7 GPa, a record‐high pressure up to which a known superconducting state can continuously survive. Remarkably, at such an ultra‐high pressure, although the ambient pressure volume is shrunk by 45% without structural phase transition, the superconducting transition temperature (T_C) increases to ≈19.1 K from ≈9.6 K, and the critical magnetic field (H_C2) at 1.8 K has been enhanced to 19 T from 15.4 T. These results set new records for both the T_C and the H_C2 among all the known alloy superconductors composed of only transition metal elements. The remarkable high‐pressure superconducting properties observed in the niobium–titanium alloy not only expand the knowledge on this important commercial superconductor but also are helpful for a better understanding on the superconducting mechanism.     

适用于Hadoop云平台的洪水淹没分析并行算法

数字高程模型(Digital Elevation Model, DEM)特殊的数据结构有利于数据在计算机中进行计算,但其数据量大,受计算机性能的限制,无法满足大规模洪水淹没分析的需要。针对单机计算能力有限以及有源淹没分析递归算法占用计算机资源较多的问题,提出了一种利用Hadoop云平台进行洪水淹没分析的并行算法。该算法对研究区域DEM按规则格网的思想进行划分,将大规模的研究区分割成多个规则的小区域。在指定水位下,对每个小区域进行数据压缩,计算每个栅格单元的淹没值,并将同一行中相连的淹没栅格序列记为淹没块,每个淹没块包含该栅格序列所属的区块号、行号、起始列号、终止列号以及淹没标记;当不同行或不同区域中的淹没块相互连通时,需对其淹没标记进行一致性设计。最终,根据淹没点所在淹没块的淹没标记提取出淹没点所在的淹没区,即为实际的淹没范围。实验结果表明,在指定淹没水位下,通过该算法可以快速提取淹没范围以及实现淹没水深的计算。