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11.
提出一种稳定的波长间隔可调谐的双波长单纵模环形光纤激光器。在复合环形谐振腔中,采用由数字微镜装置(DMD)滤波器和两个不同长度的次级环形谐振腔组成的多重滤波的方式来选择激光器的工作模式。其中,DMD滤波器可以从掺铒光纤的自发增益谱中任意选择两个波长并将它们耦合进光路中;次级环形谐振腔作为模式滤波器,可以保证激光器输出单纵模激射;利用非线性光子晶体光纤(HN-PCF)的四波混频(FWM)效应,使激光器输出均衡平稳的双波长激射。在室温条件下,不用移动实验装置中的任何器件,通过将位置不同的光栅映射在DMD滤波器上来实现双波长间隔可调谐,调谐范围为0.165nm到1.08nm,调谐步长为0.055nm。  相似文献   
12.
A new photonic signal processor topology that simultaneously achieves both a high-Q and a high skirt selectivity and stopband attenuation filter response is presented. It is based on a novel dual-cavity bandpass optical structure in which two pairs of active fiber Bragg grating cavities are used with an optical gain offset to control the poles and stopband attenuation characteristics of the filter. This concept enables a large improvement in the filter stopband attenuation, rejection bandwidth, and skirt selectivity to be realized. Measured results demonstrate both a narrow bandpass bandwidth of 0.4% of center frequency and a skirt selectivity factor of 16.6 for 40 dB rejection, which corresponds to a 6.5-fold improvement in comparison to conventional single cavity high-Q structures. To our knowledge, this is the best skirt selectivity reported for a photonic bandpass filter to date. The new photonic filter structure has been experimentally verified and excellent agreement between measured and predicted responses is shown.  相似文献   
13.
    
With six therapies approved by the Food and Drug Association, chimeric antigen receptor (CAR) T cells have reshaped cancer immunotherapy. However, these therapies rely on ex vivo viral transduction to induce permanent CAR expression in T cells, which contributes to high production costs and long-term side effects. Thus, this work aims to develop an in vivo CAR T cell engineering platform to streamline production while using mRNA to induce transient, tunable CAR expression. Specifically, an ionizable lipid nanoparticle (LNP) is utilized as these platforms have demonstrated clinical success in nucleic acid delivery. Though LNPs often accumulate in the liver, the LNP platform used here achieves extrahepatic transfection with enhanced delivery to the spleen, and it is further modified via antibody conjugation (Ab-LNPs) to target pan-T cell markers. The in vivo evaluation of these Ab-LNPs confirms that targeting is necessary for potent T cell transfection. When using these Ab-LNPs for the delivery of CAR mRNA, antibody and dose-dependent CAR expression and cytokine release are observed along with B cell depletion of up to 90%. In all, this work conjugates antibodies to LNPs with extrahepatic tropism, evaluates pan-T cell markers, and develops Ab-LNPs capable of generating functional CAR T cells in vivo.  相似文献   
14.
We have investigated the magnetooptical properties of one-dimensional magnetic photonic crystals for the case of oblique light incidence. We developed a theoretical model based on the transfer matrix approach. We found several new effects such as transmittance resonance peak shift versus external magnetic field and the Faraday effect dependence on the incidence angle. We discuss several possible one-dimensional magnetic photonic crystals applications for the optical devices.  相似文献   
15.
We propose and experimentally demonstrate a stable tunable multiwavelength laser employing a semiconductor optical amplifier (SOA) in conjunction with an opto-very-large-scale-integration (VLSI) processor. By uploading digital phase holograms onto the opto-VLSI processor, the amplified spontaneous emission of the SOA is arbitrarily sliced and injected back into the SOA to generate multiple lasing wavelengths with a linewidth of 0.5 nm. Experimental results demonstrate a tunable multiwavelength laser with a tuning range from 1528 to 1533 nm with power fluctuations of less than 0.5 dB.  相似文献   
16.
Minasian RA  Alameh KE 《Applied optics》1999,38(21):4665-4670
A new wavelength division multiplexing grating-based beam-forming architecture for phased arrays that can achieve the minimum possible number of optical interconnects is presented. A reduction in interconnect hardware of 99.6% is obtained for a 512-beam array, which is, as far as we know, the lowest number of interconnects reported to date. Analysis of the ultimate beam capacity limit of the beam former shows that the beat noise interference limitation is the most important factor. We present a new hybrid frequency-converting optical beam former that removes the fundamental beat noise limitation. This frequency downconverts the rf signal to an intermediate frequency before performing the true-time-delay equalization in the optical domain. The resulting advantage of reduced optical bandwidth per channel enables more wavelengths to be used for a given wavelength span, resulting in an increased beam capacity. A greater than sevenfold increase in beam capacity is demonstrated through the use of the frequency conversion technique, with 960 beams synthesized at 12.4 GHz, showing a 99.8% reduction in required interconnects.  相似文献   
17.
The design, operation, and characterization of CMOS imagers implemented using: 1) "regular" CMOS wafers with a 0.5-mum CMOS analog process; 2) "regular" CMOS wafers with a 0.35-mum CMOS analog process; and 3) silicon-on-insulator (SOI) wafers in conjunction with a 0.35-mum CMOS analog process, are discussed in this paper. The performances of the studied imagers are compared in terms of quantum efficiency, dark current, and optical bandwidth. It is found that there is strong dependence of quantum efficiency of the photodiodes on the architecture of the image sensor. The results of this paper are useful for designing and modeling CMOS/SOI image sensors  相似文献   
18.
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