Environmental Policy Analysis, Peer Reviewed: Assessing the Environmental Movement's Attitudes Toward Risk Assessment

Risk Assessment.     

An Ultra-Low Dose of ∆9-Tetrahydrocannabinol Alleviates Alzheimer’s Disease-Related Cognitive Impairments and Modulates TrkB Receptor Expression in a 5XFAD Mouse Model

Alzheimer’s disease (AD) is the most common form of dementia, but there is still no available treatment. Δ9-tetrahydrocannabinol (THC) is emerging as a promising therapeutic agent. Using THC in conventional high doses may have deleterious effects. Therefore, we propose to use an ultra-low dose of THC (ULD-THC). We previously published that a single injection of ULD-THC ameliorated cognitive functioning in several models of brain injuries as well as in naturally aging mice. Here, 5xFAD AD model mice received a single treatment of ULD-THC (0.002 mg/kg) after disease onset and were examined in two separate experiments for cognitive functions, neurotropic, and inflammatory factors in the hippocampus. We show that a single injection of ULD-THC alleviated cognitive impairments in 6- and 12-month-old 5xFAD mice. On the biochemical level, our results indicate an imbalance between the truncated TrkB receptor isoform and the full receptor, with AD mice showing a greater tendency to express the truncated receptor, and ULD-THC improved this imbalance. We also investigated the expression of three AD-related inflammatory markers and found an ameliorating effect of ULD-THC. The current research demonstrates for the first time the beneficial effects of a single ultra-low dose of THC in a mouse model of AD after disease onset.     

Selectins, T-cell rolling and inflammation

The selectins, a family of Ca(2+)-dependent lectins, are expressed on inflamed vascular endothelium and some leukocyte subsets, and mediate adhesive contacts between blood cells and vessel walls. These interactions are loose and reversible, operate under conditions of shear flow, and result in leukocyte rolling along the vessel wall. The structure of the selectins and their ligands makes them uniquely suited for supporting the type of bond formation and dissociation that must prevail in order for a cell to be able to roll under conditions of flow. Because rolling precedes (and appears to be essential for) the integrin-mediated firm arrest before extravasation in response to inflammatory or infectious stimuli, inhibition of selectin function has potential for anti-inflammatory therapy, but also presents some significant challenges because of the complexity of the processes involved.     

Productivity ratings of psychology programs based on publications in clinical journals.

Sought to identify the relative standing of clinical psychology programs by evaluating their frequency of publication in the major clinical journals. In addition, the relative contribution of university programs, hospital programs, medical centers, and other institutions to the clinical literature was investigated. It was found that although American Psychological Association (APA)-approved university clinical programs are responsible for the largest number of articles in the sample examined, (14 journals for the years 1975, 1976, and 1977), 6 of every 10 articles were published either by non-APA-approved academic programs or by individuals in other institutional settings. The general reputation of universities did not reflect their productivity in the clinical journals. The article includes an analysis of the major sources of publication in the clinical literature and an evaluation of the meaning of these findings for clinical psychology. (3 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)