Advanced Bioresponsive Multitasking Hydrogels in the New Era of Biomedicine

Advanced forms of hydrogels have many inherently desirable properties and can be designed with different structures and functions. In particular, bioresponsive multifunctional hydrogels can carry out sophisticated biological functions. These include in situ single-cell approaches, capturing, analysis, and release of living cells, biomimetics of cell, tissue, and tumor-specific niches. They can allow in vivo cell manipulation and act as novel drug delivery systems, allowing diagnostic, therapeutic, vaccination, and immunotherapy methods. In the present review of multitasking hydrogels, new approaches and devices classified into point-of-care testing (POCT), microarrays, single-cell/rare cell approaches, artificial membranes, biomimetic modeling systems, nanodoctors, and microneedle patches are summarized. The potentials and application of each format are critically discussed, and some limitations are highlighted. Finally, how hydrogels can enable an “all-in-one platform” to play a key role in cancer therapy, regenerative medicine, and the treatment of inflammatory, degenerative, genetic, and metabolic diseases is being looked forward to.     

Accurate analysis of carbon nanotube interconnects using transmission line model

A new technique for analysing the time-domain response of carbon nanotube (CNT) interconnects, based on transmission line modelling, that takes the effects of both contact and fundamental (quantum) resistances into account is introduced. A new sixth-order linear parametric expression for the transfer function of these lines has been presented for the first time. For verification purposes, the step response of a driver-CNT bundle-load configuration for a 32 nm technology node, using the new technique and HSPICE simulation have been compared, with which the obtained results show an excellent match. Also the effect of contact resistance on the step response, especially the propagation delay, has been studied. The obtained results show that for the length of a CNT bundle equal to 50 mum with the diameter of each individual CNT 1 nm, the propagation delay changes from 0.138 to 5.58 ns for the contact resistance values from 1 to 50 k Omega, i.e. a variation range of 39.43 times the minimum value. The related delay variations for the length values 200 mum, 500 mum and 1000 mum, are 31.37, 22.61 and 15.42 times the minimum value, respectively.     

A Novel Refined Track Initiation Algorithm for Group Targets Based on Group Model

Traditional refined track initiation methods for group targets have mistakes or loss of tracks when tracking irregular motions, for the reason that they rely on a stable relative position of group members. To solve the problem, a group dynamic model was introduced for proposing a new initiation algorithm and its whole framework. We made a self-adaptive improvement of the group separation on various group radii. After the pre-association of these groups, a state equation derived from the model was used for predictions of group members. Then a relational matrix was defined for refined data associations. Finally tracks were validated by logic-based method. Particular scenarios and Monte Carlo simulations showed that, compared with algorithms based on relative position, this algorithm has better performance on the adaptability to changes of a group structure and the correctness of initiation.     

On the mechanics of functional asymmetry in bipedal walking

This paper uses two symmetrical models, the passive compass-gait biped and a five-link 3-D biped, to computationally investigate the cause and function of gait asymmetry. We show that for a range of slope angles during passive 2-D walking and mass distributions during controlled 3-D walking, these models have asymmetric walking patterns between the left and right legs due to the phenomenon of spontaneous symmetry-breaking. In both cases a stable asymmetric family of gaits emerges from a symmetric family of gaits as the total energy increases (e.g., fast speeds). The ground reaction forces of each leg reflect different roles, roughly corresponding to support, propulsion, and motion control as proposed by the hypothesis of functional asymmetry in able-bodied human walking. These results suggest that body mechanics, independent of neurophysiological mechanisms such as leg dominance, may contribute to able-bodied gait asymmetry.     

SVM-based validation of motor unit potential trains extracted by EMG signal decomposition

Motor unit potential trains (MUPTs) extracted via electromyographic (EMG) signal decomposition can aid in the diagnosis of neuromuscular disorders and the study of the neural control of movement, but only if they are valid. In this paper, support vector machine (SVM)-based supervised classifiers are proposed to estimate the validity of extracted MUPTs. The classifiers use either the MU firing pattern or the MUP shape consistency of an MUPT, or both, to estimate its validity. The developed classifiers estimate the class label of an MUPT (i.e., valid/invalid) and a degree of support for the decision being made. A single SVM that estimates the validity of a given MUPT using extracted MU firing pattern and MUP shape features was investigated. In addition, the effectiveness of multiclassifier techniques which estimate the overall validity of a train by fusing the MU firing pattern and MUP shape validity of a given MUPT, determined separately by two distinct SVMs, was also investigated. Training based only on simulated data showed robust classification performance of the several multiclassifier methods when tested using both simulated and real test data. Of the methods studied, the multiclassifier constructed using trainable logistic regression to aggregate base classifier outputs had the best performance. Assuming 12.7% of extracted MUPTs are on average invalid, the estimated accuracy for this method in correctly categorizing MUPTs extracted during decomposition was 99.4% and 98.8% for simulated and real data, respectively.     

High IIP3 and Low-Noise CMOS Mixer Using Non-linear Feedback Technique

A third-order intermodulation cancelation technique using a non-linear feedback is proposed to design a low-power low-distortion mixer in a 65 nm standard CMOS technology. The IM3 cancelation is achieved by estimating distorting error at a non-linear feedback element and subtracting it from the input. The linearization technique is utilized in the input trans-conductance of the mixer. The circuit functionality is analyzed using Volterra series. The covering frequency range of the mixer is 800 MHz to 5 GHz. The technique increases the input-referred third-order intercept point (IIP3) and input 1 dB compression point to +16.4 dBm and −1.87 dBm, respectively. It obtains a gain of 9 dB and an input-referred noise of 1.84 nV/?{}/\sqrt{}Hz while consumes 8.75 mA from 1.2 V supply. The layout of the mixer occupies 0.315 mm × 0.296 mm of silicon area.     

Organic field-effect transistor circuits using atomic layer deposited gate dielectrics patterned by reverse stamping

We report on a reverse stamping method to produce via-holes in circuits comprising acene-based top-gate organic field-effect transistors (OFETs) having a CYTOP/Al₂O₃ (by atomic layer deposition) bilayer gate dielectric. This method relies on the weak adhesive force that exists between a small molecule acene film and a polymer to enable easy delamination of the bilayer gate dielectric by using a PDMS stamp. We demonstrate the effectiveness of this method by fabricating simple circuits using top-gate triisopropylsilylethynyl pentacene (TIPS-pentacene)/poly (triarylamine) (PTAA) OFETs.     

Energy efficiency optimization of one-way and two-way DF relaying considering circuit power

In this paper, the energy efficiency (EE) of a decode and forward (DF) relay system is studied, where two sources communicate through a half-duplex relay node in one-way and two-way relaying strategies. Both the circuitry power and the transmission power of all nodes are taken into consideration. In addition, three different coding schemes for two-way DF relaying strategy with two phases and two-way DF relaying with three phases are considered. The aim is to maximize the EE of the system for a constant spectral efficiency (SE). For this purpose, the transmission time and the transmission power of each node are optimized. Simulations are used to compare the EE–SE curve of different DF strategies with one-way and two-way amplify and forward (AF) strategies and direct transmission (DT), to find the best energy efficient strategy in different SE conditions. Analytical and simulation results demonstrate that in low SE conditions, DF relaying strategies are more energy efficient compared to that of AF strategies and DT. However, in high SE conditions, the EE of two-way AF relaying and DT strategy outperform some of the DF relaying strategies. In simulations, the impact of different circuitry power and different channel conditions on the EE–SE curves are also investigated.