Multimedia Tools and Applications - Selective image encryption has a significant importance in many applications as it offers significant savings in computations, cost, and time. Many attempts are... 相似文献
SARS-CoV-2 currently lacks effective first-line drug treatment. We present promising data from in silico docking studies of new Methisazone compounds (modified with calcium, Ca; iron, Fe; magnesium, Mg; manganese, Mn; or zinc, Zn) designed to bind more strongly to key proteins involved in replication of SARS-CoV-2. In this in silico molecular docking study, we investigated the inhibiting role of Methisazone and the modified drugs against SARS-CoV-2 proteins: ribonucleic acid (RNA)-dependent RNA polymerase (RdRp), spike protein, papain-like protease (PlPr), and main protease (MPro). We found that the highest binding interactions were found with the spike protein (6VYB), with the highest overall binding being observed with Mn-bound Methisazone at −8.3 kcal/mol, followed by Zn and Ca at −8.0 kcal/mol, and Fe and Mg at −7.9 kcal/mol. We also found that the metal-modified Methisazone had higher affinity for PlPr and MPro. In addition, we identified multiple binding pockets that could be singly or multiply occupied on all proteins tested. The best binding energy was with Mn–Methisazone versus spike protein, and the largest cumulative increases in binding energies were found with PlPr. We suggest that further studies are warranted to identify whether these compounds may be effective for treatment and/or prophylaxis. 相似文献
The use of lean burn technology in spark-ignition engines has been dominant; however, lean burn technique can not economically satisfy the increasingly restricted future emission standards. Consequently, alternative combustion techniques need to be investigated and developed. In this paper, the use of the stoichiometric air-fuel mixture with exhaust gas recirculation (EGR) technique in a spark-ignition natural gas engine was experimentally investigated. Engine performance and NO emissions were studied for both atmospheric and supercharged inlet conditions. It was found that the use of EGR has a significant effect on NO emissions. NO emissions decreased by about 50% when EGR dilution increased from zero with an inlet pressure of 101 kPa to close to the misfire limit with an inlet pressure of 113 kPa. In addition, the use of EGR effectively suppressed abnormal combustion which occurred at higher inlet pressure. The use of higher inlet pressure in the presence of EGR improved engine performance significantly. Engine brake power increased by about 20% and engine fuel consumption decreased by about 7% while NO emissions decreased by about 12% when 5% of EGR dilution was employed with an inlet pressure of 113 kPa compared to using undiluted stoichiometric inlet mixture with an inlet pressure of 101 kPa. 相似文献
Fractional Brownian motion (fBm) emerged as a useful model for self-similar and long-range dependent aggregate Internet traffic. Asymptotic, respectively, approximate performance measures are known for single queueing systems with fBm through traffic. In this paper end-to-end performance bounds for a through flow in a network of tandem queues under open-loop fBm cross traffic are derived. To this end, a rigorous sample path envelope for fBm is proven that complements previous approximate results. The sample path envelope and the concept of leftover service curves are employed to model the remaining service after scheduling fBm cross traffic at a queuing system. Using composition results for tandem systems from the stochastic network calculus end-to-end statistical performance bounds for individual flows in networks under fBm cross traffic are derived. The discovery is that these bounds grow in O(n(logn)1/(2-2H)) for n systems in series where H is the Hurst parameter of the cross traffic. Explicit results on the impact of the variability and the burstiness of through and cross traffic on network performance are shown. Our analysis has direct implications on fundamental questions in network planning and service management. 相似文献
Image denoising is an important component of image processing. The interest in the use of Riesz fractional order derivative has been rapidly growing for image processing recently. This paper mainly introduces the concept of fractional calculus and proposes a new mathematical model in using the convolution of fractional Tsallis entropy with the Riesz fractional derivative for image denoising. The structures of n × n fractional mask windows in the x and y directions of this algorithm are constructed. The image denoising performance is assessed using the visual perception, and the objective image quality metrics, such as peak signal-to-noise ratio (PSNR), and structural similarity index (SSIM). The proposed algorithm achieved average PSNR of 28.92 dB and SSIM of 0.8041. The experimental results prove that the improvements achieved are compatible with other standard image smoothing filters (Gaussian, Kuan, and Homomorphic Wiener).