Evaluation of in vitro stability of large unilamellar liposomes coated with a modified polysaccharide (O-palmitoylpullulan)

Aiming at encapsulation of a hydrosoluble drug, large unilamellar liposomes (LUV) of egg phosphatidylcholine (PC) were coated with a natural polysaccharide derivative, O-palmitoylpullulan (OPP), and its in vitro stability evaluated using fluorescent probes. This coating (in OPP/PC weight ratio of 3) improved significantly the in vitro stability of LUV by decreasing both the permeability and fluidity of the liposomal membrane.This paper was accepted for publication after the 1995 Conference of the European Society of Biomaterials, Oporto, Portugal, 10–13 September.     

Optimal discrimination and classification of neuronal actionpotential waveforms from multiunit, multichannel recordings usingsoftware-based linear filters

Describes advanced protocols for the discrimination and classification of neuronal spike waveforms within multichannel electrophysiological recordings. The programs are capable of detecting and classifying the spikes from multiple, simultaneously active neurons, even in situations where there is a high degree of spike waveform superposition on the recording channels. The protocols are based on the derivation of an optimal linear filter for each individual neuron. Each filter is tuned to selectively respond to the spike waveform generated by the corresponding neuron, and to attenuate noise and the spike waveforms from all other neurons. The protocol is essentially an extension of earlier work (S. Andreassen et al., 1979; W.M. Roberts and D.K. Hartline, 1975; R.B. Stein et al., 1979). However, the protocols extend the power and utility of the original implementations in two significant respects. First, a general single-pass automatic template estimation algorithm was derived and implemented. Second, the filters were implemented within a software environment providing a greatly enhanced functional organization and user interface. The utility of the analysis approach was demonstrated on samples of multiunit electrophysiological recordings from the cricket abdominal nerve cord     

Prediction of thermal expansion coefficients of plain weave fabric composites

Three plain weave fabric composite analysis models are presented for the prediction of the on-axes thermal expansion coefficients. These are two-dimensional models in the sense that the actual strand cross-sectional geometry, strand undulation and the presence of a gap between the adjacent strands are taken into account. In the first two models, termed refined models, the representative unit cell is discretised into slices and elements and analysed. In the third method, a closed-form solution is presented. In this case, the representative unit cell is idealised as a crossply laminate and analysed. The relative merits and demerits of the models are also discussed. The predicted results are compared with the experimental values. A good correlation is observed.     

Post-Supervised Template Induction for Information Extraction from Lists and Tables in Dynamic Web Sources

Dynamic web sites commonly return information in the form of lists and tables. Although hand crafting an extraction program for a specific template is time-consuming but straightforward, it is desirable to automatically generate template extraction programs from examples of lists and tables in html documents. Supervised approaches have been shown to achieve high accuracy, but they require manual labelling of training examples, which is also time consuming. Fully unsupervised approaches, which extract rows and columns by detecting regularities in the data, cannot provide sufficient accuracy for practical domains. We describe a novel technique, Post-supervised Learning, which exploits unsupervised learning to avoid the need for training examples, while minimally involving the user to achieve high accuracy. We have developed unsupervised algorithms to extract the number of rows and adopted a dynamic programming algorithm for extracting columns. Our method achieves high performance with minimal user input compared to fully supervised techniques.     

A Programmable Pulse Sequence Generator for an NMR Relaxometer

A pulse sequence generator for NMR relaxometer is described. The operation mode is loaded into the internal memory of the device by a program from a personal computer via a PCI bus. The project is realized on two MAX7000S and Cyclone (Altera) chips using the Qartus II 4.0 software. The basic parameters of the device are as follows: the minimal pulse length is 50 ns, the time resolution is 10 ns, the maximum number of pulses is 1024, and the number of controlled output channels is 8. This device, operating in the automatic mode as part of the hardware-software NMR system, makes possible recording, processing, and storing experimental results in electronic form.     

Diagnostics and monitoring of complex production processes using measurement of vibration-acoustic signals

A vibration-acoustic method for diagnostics and monitoring of production processes such as cutting metals makes it possible compared with other methods to reduce the requirement for measuring equipment and it provides a computer representation of the results observed. The set of equipment suggested has low cost and it exhibits considerable flexibility compared with existing equipment. __________ Translated from Izmeritel’naya Tekhnika, No. 7, pp. 30–34, July, 2006.     

Simulation of the VVER-1000 pump start-up experiment of the OECD V1000CT benchmark with CATHARE and TRAC-PF1

In the framework of joint effort between the Nuclear Energy Agency (NEA) of OECD, the United States Department of Energy (US DOE), and the Commissariat a l'Energie Atomique (CEA), France a coupled three-dimensional (3D) thermal-hydraulics/neutron kinetics benchmark for VVER-1000 was defined. The benchmark consists of calculation of a pump start-up experiment labelled V1000CT-1 (Phase 1), as well as a vessel mixing experiment and main steam line break (MSLB) transient labelled V1000CT-2 (Phase 2), respectively. The reference nuclear plant is Kozloduy-6 in Bulgaria. The overall objective is to assess computer codes used in the analysis of VVER-1000 reactivity transients. A specific objective is to assess the vessel mixing models used in system codes. Plant data are available for code validation consisting of one experiment of pump start-up (V1000CT-1) and one experiment of steam generator isolation (V1000CT-2). The validated codes can be used to calculate asymmetric MSLB transients involving similar mixing patterns. This paper summarizes a comparison of CATHARE and TRAC-PF1 system code results for V1000CT-1, Exercise 1, which is a full plant point kinetics simulation of a reactor coolant system (RCS) pump start-up experiment. The reference plant data include integral and sector average parameters. The comparison is made from the point of view of vessel mixing and full system simulation. CATHARE used a six-sector multiple 1D vessel thermal-hydraulic model with cross flows and TRAC used a six-sector, 18-channel coarse-mesh 3D vessel model. Good agreement in terms of integral parameters and inter-loop mixing is observed.     

Measurement of the relative reduction of strip on the 1200-model temper-rolling mills in flat-rolled products shop No. 3

The temper-rolling mills in flat-rolled products shop No. 3 at the MMK has been equipped with the Vytyazhka automated system to measure the elongation of strip (ASEMS) rolled on the mill. The elongation (relative elongation) of the strip is determined through a frequency-based method of measuring the speed of the strip before and after reduction. The system transmits and displays information on the temper-rolling of each coil. The information is shown as a diagram on the monitor of an industrial computer. The reliability of the system allows it to be in continuous use. Introduction of the automated elongation measurement system makes it possible to monitor the reductions being made during temperrolling, which in turn enables the shop to reduce the number of products having properties that do not meet customers’ requirements. __________ Translated from Metallurg, No. 1, pp. 62–63, January, 2007.