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201.
Tatyana Chernova Stefano Grosso Xiao-Ming Sun Angela Rubio Tenor Joaquin Zacarias Cabeza Andrew Craxton Emily L. Self Apostolos Nakas Kelvin Cain Marion MacFarlane Anne E. Willis 《International journal of molecular sciences》2022,23(20)
Malignant mesothelioma is an aggressive tumour of the pleura (MPM) or peritoneum with a clinical presentation at an advanced stage of the disease. Current therapies only marginally improve survival and there is an urgent need to identify new treatments. Carcinoma-associated fibroblasts (CAFs) represent the main component of a vast stroma within MPM and play an important role in the tumour microenvironment. The influence of CAFs on cancer progression, aggressiveness and metastasis is well understood; however, the role of CAF-derived extracellular vesicles (CAF-EVs) in the promotion of tumour development and invasiveness is underexplored. We purified CAF-EVs from MPM-associated cells and healthy dermal human fibroblasts and examined their effect on cell proliferation and motility. The data show that exposure of healthy mesothelial cells to EVs derived from CAFs, but not from normal dermal human fibroblasts (NDHF) resulted in activating pro-oncogenic signalling pathways and increased proliferation and motility. Consistent with its role in suppressing Yes-Associated Protein (YAP) activation (which in MPM is a result of Hippo pathway inactivation), treatment with Simvastatin ameliorated the pro-oncogenic effects instigated by CAF-EVs by mechanisms involving both a reduction in EV number and changes in EV cargo. Collectively, these data determine the significance of CAF-derived EVs in mesothelioma development and progression and suggest new targets in cancer therapy. 相似文献
202.
Maria Joo Bessa Ftima Brando Paul H. B. Fokkens Daan L. A. C. Leseman A. John F. Boere Flemming R. Cassee Apostolos Salmatonidis Mar Viana Eliseo Monfort Snia Fraga Joo Paulo Teixeira 《International journal of molecular sciences》2022,23(8)
High-energy industrial processes have been associated with particle release into workplace air that can adversely affect workers’ health. The present study assessed the toxicity of incidental fine (PGFP) and nanoparticles (PGNP) emitted from atmospheric plasma (APS) and high-velocity oxy-fuel (HVOF) thermal spraying. Lactate dehydrogenase (LDH) release, 2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate (WST-1) metabolisation, intracellular reactive oxygen species (ROS) levels, cell cycle changes, histone H2AX phosphorylation (γ-H2AX) and DNA damage were evaluated in human alveolar epithelial cells at 24 h after exposure. Overall, HVOF particles were the most cytotoxic to human alveolar cells, with cell viability half-maximal inhibitory concentration (IC50) values of 20.18 µg/cm2 and 1.79 µg/cm2 for PGFP and PGNP, respectively. Only the highest tested concentration of APS-PGFP caused a slight decrease in cell viability. Particle uptake, cell cycle arrest at S + G2/M and γ-H2AX augmentation were observed after exposure to all tested particles. However, higher levels of γ-H2AX were found in cells exposed to APS-derived particles (~16%), while cells exposed to HVOF particles exhibited increased levels of oxidative damage (~17% tail intensity) and ROS (~184%). Accordingly, APS and HVOF particles seem to exert their genotoxic effects by different mechanisms, highlighting that the health risks of these process-generated particles at industrial settings should not be underestimated. 相似文献
203.
Apostolos AmpatzoglouAuthor Vitae Apostolos Kritikos Author VitaeGeorge Kakarontzas Author Vitae Ioannis Stamelos Author Vitae 《Journal of Systems and Software》2011,84(12):2265-2283
Nowadays open-source software communities are thriving. Successful open-source projects are competitive and the amount of source code that is freely available offers great reuse opportunities to software developers. Thus, it is expected that several requirements can be implemented based on open source software reuse. Additionally, design patterns, i.e. well-known solution to common design problems, are introduced as elements of reuse. This study attempts to empirically investigate the reusability of design patterns, classes and software packages. Thus, the results can help developers to identify the most beneficial starting points for white box reuse, which is quite popular among open source communities. In order to achieve this goal we conducted a case study on one hundred (100) open source projects. More specifically, we identified 27,461 classes that participate in design patterns and compared the reusability of each of these classes with the reusability of the pattern and the package that this class belongs to. In more than 40% of the cases investigated, design pattern based class selection, offers the most reusable starting point for white-box reuse. However there are several cases when package based selection might be preferable. The results suggest that each pattern has different level of reusability. 相似文献
204.
Context
Software quality is considered to be one of the most important concerns of software production teams. Additionally, design patterns are documented solutions to common design problems that are expected to enhance software quality. Until now, the results on the effect of design patterns on software quality are controversial.Aims
This study aims to propose a methodology for comparing design patterns to alternative designs with an analytical method. Additionally, the study illustrates the methodology by comparing three design patterns with two alternative solutions, with respect to several quality attributes.Method
The paper introduces a theoretical/analytical methodology to compare sets of “canonical” solutions to design problems. The study is theoretical in the sense that the solutions are disconnected from real systems, even though they stem from concrete problems. The study is analytical in the sense that the solutions are compared based on their possible numbers of classes and on equations representing the values of the various structural quality attributes in function of these numbers of classes. The exploratory designs have been produced by studying the literature, by investigating open-source projects and by using design patterns. In addition to that, we have created a tool that helps practitioners in choosing the optimal design solution, according to their special needs.Results
The results of our research suggest that the decision of applying a design pattern is usually a trade-off, because patterns are not universally good or bad. Patterns typically improve certain aspects of software quality, while they might weaken some other.Conclusions
Concluding the proposed methodology is applicable for comparing patterns and alternative designs, and highlights existing threshold that when surpassed the design pattern is getting more or less beneficial than the alternative design. More specifically, the identification of such thresholds can become very useful for decision making during system design and refactoring. 相似文献205.
Arvanitou Elvira-Maria Ampatzoglou Apostolos Chatzigeorgiou Alexander Avgeriou Paris Tsiridis Nikolaos 《Software Quality Journal》2022,30(3):853-883
Software Quality Journal - During software maintenance, it is often costlier to identify and understand the artifacts that need to be changed, rather than to actually apply the change. In addition... 相似文献
206.
Apostolos Giannis Michael Kalaitzakis Evan Diamadopoulos 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2007,82(7):663-671
Background Olive mill wastewater (OMW) constitutes a very strong agro‐industrial wastewater posing severe environmental threats in olive oil producing countries. The main objective of this study was to treat olive mill wastewater by electrochemical oxidation. The variables studied included the type and concentration of electrolyte solutions, voltage and time applied. Results: The electrolyte type and concentration significantly affected the degradation efficiency of the electrochemical oxidation. Optimal conditions for NaCl concentration were 3% (w/v) and 16 V. At these conditions chemical oxygen demand (COD) removal reached 70.8% after 8 h of electrochemical treatment, while color and turbidity were completely removed after short periods of treatment. However, bio‐assays indicated that the ecotoxicity of the treated wastewater remained unchanged, possibly due to the formation of chlorinated by‐products. Na2SO4 did not demonstrate sufficient efficiency. The simultaneous use of FeCl3 and NaCl contributed to electro‐coagulation of OMW. After settlement, two separate phases were formed: the supernatant phase and the settled solids. Under optimal conditions (2% Na2SO4 + 1% FeCl3; 24 V), the removal efficiency of COD reached 85.5% at the supernatant phase. Conclusion: NaCl was an effective electrolyte for OMW treatment. The electro‐coagulation process was also a successful process, but as in the case of NaCl the remaining acute toxicity of treated OMW was high. Copyright © 2007 Society of Chemical Industry 相似文献
207.
Kaouther Ben Hassine Milad El Riachy Amani Taamalli Dhafer Malouche Mohamed Ayadi Khouloud Talmoudi Maroua Aouini Yosra Jlassi Cinzia Benincasa Elvira Romano Enzo Perri Apostolos Kiristakis Mokhtar Hamdi Naziha Grati‐Kammoun Mohamed Hammami 《European Journal of Lipid Science and Technology》2014,116(7):812-824
208.
Ta‐Ko Chuang Matias Troccoli Miltiadis Hatalis Apostolos T. Voutsas 《Journal of the Society for Information Display》2007,15(7):455-461
Abstract— A top‐emitting 230‐dpi active‐matrix polymer light‐emitting diode (AMPLED) display, having a VGA format and a 3.3‐in.‐diagonal size, on a flexible stainless‐steel‐foil substrate is reported. The active‐matrix array was fabricated with laser‐crystallized polysilicon TFTs at a maximum process temperature of 700°C. The top‐emitting PLED diodes were prepared by spin‐casting organic light‐emitting polymers. This work demonstrates the compatibility of polysilicon‐TFT technology with flexible metal‐foil substrates for active‐matrix organic light‐emitting‐diode (AMOLED) display applications. 相似文献
209.
Apostolos Kousaridas Alexandros Kaloxylos Panagis Magdalinos Thanos Makris Georgios Koudouridis Gunnar Hedby Nancy Alonistioti 《International Journal of Network Management》2014,24(2):121-152
The concept of self‐organizing networks is considered one of the most promising approaches for the efficient management of future wireless networks that will support a large number of nodes and a plethora of services with diverse characteristics. Today, different types of networks (e.g. WLANs, wireless sensor networks) are deployed to serve different needs but do not interoperate. Their possible loose integration will provide opportunities that could be exploited through collaborative approaches to devise novel solutions to extend the capabilities and improve the performance of these networks. The self‐growing paradigm addresses this challenge by extending network nodes to dynamically evolve in terms of purpose and operational features. In this paper we describe the CONSERN architecture, which targets the realization of the self‐growing concept in the context of self‐organized networks. To test our ideas we designed and implemented a WLAN topology optimization scheme that provides the best coverage at a minimum energy consumption, through dynamic access point (AP) deactivation and reactivation. Using self‐growing mechanisms and typical motion detectors we present how the operation of the proposed topology optimization mechanism can be improved. The reduced energy consumption attained under the proposed scheme at the AP side, as well as the efficient utilization of network resources, are evaluated via a proof‐of‐concept implementation that we have deployed in a real office environment that consists of WLAN APs and motion sensors. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
210.
Multiple radioactive particle tracking is a noninvasive technique used to study flow phenomena within gas‐solid fluidized beds. Five tagged polyethylene particles were added to a fluidized bed and tracked using two gamma cameras set perpendicular to one another. One camera collected x‐z particle locations and the other collected y‐z particle locations, while both cameras collected particle count rate values. The x‐z and y‐z particle movement information was combined to form three‐dimensional particle trajectories, and in turn used to calculate instantaneous flow information. The information from the five particles was then averaged and used to calculate three‐dimensional information regarding solid circulation parameters. 相似文献