Simulation of vacuum distillation to produce alcohol-free beer

Several processes have been developed for producing alcohol-free beer while maintaining desirable sensory characteristics. One of the most popular thermal processes used is distillation, where not only ethanol but volatile aromatic components are partly or completely removed from the beer. Based on data from the literature and using the Aspen Plus simulator, this study evaluates and compares the aroma profiles of alcohol-free beers obtained by continuous vacuum distillation with different pressures and processes. Three processes were simulated at pressures of 60, 102, and 200 mbar. The first (Process A) was a standard continuous vacuum distillation, where the bottom product was an alcohol-free beer. In the second (Process B), the bottom product was blended with a standard beer that had not undergone any thermal process. In the third (Process C), part of the top stream was mixed with the bottom product. This study considered eight major compounds in beer: ethanol, propanol, isobutanol, 2-methyl-1-butanol, 3-methyl-1-butanol, ethyl acetate, diacetyl and isoamyl acetate. The three simulated pressure ranges showed similar results, indicating that reducing the pressure below 200 mbar did not improve separation. Further, vacuum distillation did not remove diacetyl from the beer. Processes B and C resulted in beer that was richer in flavour compounds. Furthermore, when these processes were compared to Process A, the concentration of esters was markedly higher. © 2019 The Institute of Brewing & Distilling     

Measuring and visualizing information transfer in networked collaboration

Networked operations are a reality as companies are exploiting the electronic medium to distribute, disseminate and communicate information in‐house and across the organizational boundaries. The article defines a set of metrics which enable to visualize the performance of the organization through its electronic communication and behaviour. Relying on document usage as the source of raw data the article presents a model to visualize the true communication network of the organization. A software application using this approach is presented and the experiences are documented. Main results strongly indicate that an analysis together with advanced visualization techniques provide management with a unique view on how the organization is performing and how its efficiency can be improved. Information networks are not only speeding up communication but also serve as a means to better understand how complicated and creative processes like product development and large‐scale software projects take place and how the traditional hazard‐driven management approach can become more proactive in nature. Copyright © 1999 John Wiley & Sons, Ltd.     

GaInAs/AlGaAs应变量子阱结构的荧光特性

本文报道了4—300K温度范围内量子阱宽度分别为20、40、90和130A的GaInAs/AlGaAs应变量子阱结构的光荧光特性。我们考虑量子尺寸对载流子子能带的影响和弹性应变引起带隙的移动,计算了量子阱中本征激子发光的能量位置,计算值与实验结果基本吻合。还研究了荧光峰强度随阱宽的变化以及不同温度下荧光峰的半高宽度。     

Approximating the Advertisement Placement Problem

The advertisement placement problem deals with space and time sharing by advertisements on the Internet. Consider a Web page containing a rectangular display area (e.g., a banner) in which advertisements may appear. The display area can be utilized efficiently by allowing several small ads to appear simultaneously side by side, as well as by cycling through a schedule of ads, allowing different ads to be displayed at different times. A customer wishing to purchase advertising space specifies an ad size and a display count, which is the number of times their ad should appear during each cycle. The scheduler may accept or reject any given advertisement, but must be able to schedule all accepted ads within the given time and space constraints. Each advertisement has a non-negative profit associated with it, and the objective is to schedule a maximum-profit subset of ads. We present a (3 + )-approximation algorithm for the general problem, as well as (2 + )-approximation algorithms for two special cases.     

Optimal structure for heat and cold protection under transient heat conduction

A suitable combination of materials for sheltering a system from a sudden change of environmental temperature has been theoretically studied. The protective composite wall consists of two materials. An insulating material is placed on the outer surface, while, for the inner surface, materials that have good heat storage properties but negligible heat transfer resistance are chosen. The results show that by replacing some of the insulation material with a heat storage material, the temperature of the protected system can be maintained at a considerably lower level. Although the optimal thickness ratio X depends on the Biot number, Fourier number, and on the heat capacity ratio K _C, for a large number of thermal protection cases, the approximation X = 0.45 yields practically the minimum progress of the transient. If the Biot number is sufficiently small, it is better to replace all of the insulation material with a good heat storage material.     

Introduction of lysine residues on the light chain constant domain improves the labelling properties of a recombinant Fab fragment

Europium chelates provide a non-radioactive alternative forsensitive labelling of antibodies for diagnostic immunoassays.Lysine residues at antibody surfaces are ready targets for labellingby an isothiocyanate derivative of the europium chelate (Eu³⁺).Here the labelling efficiency of a recombinant anti-human -fetoprotein(hAFP) Fab fragment has been improved by increasing its lysinecontent by protein engineering. Molecular modelling was usedto identify three light chain constant domain surface arginineresidues, R154, R187 and R210, which were mutated to lysineresidues. The mutations did not influence the affinity of thelysine-enriched Fab fragment and its labelling efficiency wasfound to be 40% higher than that of the wildtype Fab fragmentWith low degree of labelling, the affinities of the two Fabfragments were identical and comparable with that of the originalmonoclonal anti-hAFP IgG. With a higher degree of labellingthe affinities of both Fab fragments decreased more than thatof the intact IgG since more lysine residues are available forlabelling in the additional heavy chain constant domains ofthe larger molecule. Electrostatic adsorption and covalent immobilizationof the Fab fragments were characterized by BIAcore^TM and thelysine-enriched Fab fragment was found to be more efficientlyimmobilized to an activated carboxymethyl surface.     

Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking

We have determined the three-dimensional structure of the protein complex between latexin and carboxypeptidase A using a combination of chemical cross-linking, mass spectrometry and molecular docking. The locations of three intermolecular cross-links were identified using mass spectrometry and these constraints were used in combination with a speed-optimised docking algorithm allowing us to evaluate more than 3 x 10(11) possible conformations. While cross-links represent only limited structural constraints, the combination of only three experimental cross-links with very basic molecular docking was sufficient to determine the complex structure. The crystal structure of the complex between latexin and carboxypeptidase A4 determined recently allowed us to assess the success of this structure determination approach. Our structure was shown to be within 4 A r.m.s. deviation of Calpha atoms of the crystal structure. The study demonstrates that cross-linking in combination with mass spectrometry can lead to efficient and accurate structural modelling of protein complexes.     

Three-dimensional phase step profilometry with a multicore optical fiber

This paper demonstrates the feasibility of using phase stepping and a multicore optical fiber to calculate an object's depth profile. An interference pattern is projected by an optical fiber onto the object. The distorted interference pattern containing the object information is captured by a CCD camera and processed using a phase step interferometry method. The phase step method is less computationally intensive compared to two-dimensional Fourier transform profilometry and provides more accuracy when measuring objects of high frequency spatial variations.     

Selective Supramolecular Fullerene-Porphyrin Interactions and Switching in Surface-Confined C(60)-Ce(TPP)(2) Dyads

The control of organic molecules, supramolecular complexes and donor-acceptor systems at interfaces is a key issue in the development of novel hybrid architectures for regulation of charge-carrier transport pathways in nanoelectronics or organic photovoltaics. However, at present little is known regarding the intricate features of stacked molecular nanostructures stabilized by noncovalent interactions. Here we explore at the single molecule level the geometry and electronic properties of model donor-acceptor dyads stabilized by van der Waals interactions on a single crystal Ag(111) support. Our combined scanning tunneling microscopy/spectroscopy (STM/STS) and first-principles computational modeling study reveals site-selective positioning of C(60) molecules on Ce(TPP)(2) porphyrin double-decker arrays with the fullerene centered on the π-system of the top bowl-shaped tetrapyrrole macrocycle. Three specific orientations of the C(60) cage in the van der Waals complex are identified that can be reversibly switched by STM manipulation protocols. Each configuration presents a distinct conductivity, which accounts for a tristable molecular switch and the tunability of the intradyad coupling. In addition, STS data evidence electronic decoupling of the hovering C(60) units from the metal substrate, a prerequisite for photophysical applications.     

Occurrence of Superconductivity and Magnetism in Nominally Undoped LaOFeAs

Superconductivity in a LaOFeAs system is known to get introduced by F-doping (LaO_1−x F _x FeAs) even under ambient conditions and oxygen deficiency (LaO_1−x FeAs) under high pressure conditions. Hitherto unreported, superconductivity in F-free undoped LaOFeAs samples is observed and confirmed for the first time by various characterization tools–resistive ρ(T,B), magnetic M(T,B) and modulated microwave absorption (MMA) measurements. The ρ(T) at B=0 shows a clear superconducting transition with an onset at T _con∼17 K and a tail-like behavior when R goes to zero at T _c0∼8 K. In the presence of B, the superconducting transition shifts to lower T with a rate ∼−5.5 and −1.65 T/K, depending on whether the ρ(T) has dropped to 90% or 5% of its normal state value, respectively. M(T) in zero field cooling at B=10 mT shows diamagnetic downturn below at ∼12 K. At T<T _c0 the change in MMA with B shows a low field (B∼1 mT) peak, which vanishes at T>T _c0, indicating the presence of weak link superconducting networks in the sample. The sample shows a complex electrical and magnetic behavior in the normal state. For instance, ρ(T) reveals a weak SDW-like anomaly at T∼132 K along with a resistivity minimum at T _min∼78 K. M(T) also shows the presence of a magnetic anomaly at T∼130 K. Both below and above T _con, presence of an additional ferromagnetic component is observed in the isothermal M(B) loop measurements. The superconducting and normal state features of our sample are compared with other undoped and doped LaOFeAs systems reported in the literature.