A project scheduling approach to production and material requirement planning in Manufacturing-to-Order environments

Long- and medium-term production planning are tools to match production orders with resource capacity and that can also be used as a baseline for material procurement. The lack of a detailed schedule for the manufacturing operations, however, may cause difficulties in providing a proper material requirements planning and may affect the feasibility of the production plan itself. This paper proposes an approach, based on production process knowledge, to extract scheduling information from an aggregate production plan in order to support material procurement. The proposed approach is applied to an industrial case involving machining center production.     

Tumor Accumulation and Off-Target Biodistribution of an Indocyanine-Green Fluorescent Nanotracer: An Ex Vivo Study on an Orthotopic Murine Model of Breast Cancer

Indocyanine green (ICG) is a near infrared fluorescent tracer used in image-guided surgery to assist surgeons during resection. Despite appearing as a very promising tool for surgical oncology, its employment in this area is limited to lymph node mapping or to laparoscopic surgery, as it lacks tumor targeting specificity. Recently, a nanoformulation of this dye has been proposed with the aim toward tumor targeting specificity in order to expand its employment in surgical oncology. This nanosystem is constituted by 24 monomers of H-Ferritin (HFn), which self-assemble into a spherical cage structure enclosing the indocyanine green fluorescent tracer. These HFn nanocages were demonstrated to display tumor homing due to the specific interaction between the HFn nanocage and transferrin receptor 1, which is overexpressed in most tumor tissues. Here, we provide an ex vivo detailed comparison between the biodistribution of this nanotracer and free ICG, combining the results obtained with the Karl Storz endoscope that is currently used in clinical practice and the quantification of the ICG signal derived from the fluorescence imaging system IVIS Lumina II. These insights demonstrate the suitability of this novel HFn-based nanosystem in fluorescence-guided oncological surgery.     

Global Assessment of Seawater Intrusion Problems (Status and Vulnerability)

In this research paper we propose a novel method to perform an integrated analysis of the status and vulnerability of coastal aquifers to seawater intrusion (SWI). The method is based on a conceptual approach of intrusion that allows to summarised results in a visual way at different spatial scales, moving from steady pictures (corresponding to instantaneous or mean values in a period) including maps and 2D conceptual cross-sections and temporal series of lumped indices. Our aim is to help in the identification of coastal groundwater bodies at risk of not achieving good chemical status according to the Water Framework Directive. The indices are obtained from available information about aquifer geometry and historical monitoring data (chloride concentration and hydraulic head data). This method may be applied even in cases where a reduced number of data are available. It does not require complex modelling and has been implemented in a GIS tool that encourages its use in other cases. Analysis of the evolution of historical time series of these indices can be used to assess resilience and trends with respect to SWI problems. This method can be also useful to compare intrusion problems in different aquifers and temporal periods.     

Modelling the evolution of oxidative browning during storage of white wines: effects of packaging and closures

Shelf life of products is a key parameter for any company at local and international level that wish to improve their competitiveness; thus, there is a need to search for methods that allow one to predict the shelf life of bottled wines. In this view, the progress of chemical oxidative reactions of six Italian white wines during storage (10 months after bottling), in different packaging, was monitored by means of selected oenological parameters. The optical density at 420 nm, an index of browning, showed a progressive increase that fitted the zero‐order kinetic rate. The onset of wine browning was further tested by means of accelerated ageing in controlled temperature conditions which results, modelled using the rate constants approach, showed an Arrhenius‐like dependence from temperature, allowing to estimate apparent activation energies of oxidative chemical browning (range: 46.8–88.3 kJ mol^?1). Kinetic and thermodynamic approach provided a useful tool to predict quality changes of white wines during storage with respect to packaging conditions.     

Characterization of Mesenchymal Stem Cell Differentiation within Miniaturized 3D Scaffolds through Advanced Microscopy Techniques

Three-dimensional culture systems and suitable substrates topographies demonstrated to drive stem cell fate in vitro by mechanical conditioning. For example, the Nichoid 3D scaffold remodels stem cells and shapes nuclei, thus promoting stem cell expansion and stemness maintenance. However, the mechanisms involved in force transmission and in biochemical signaling at the basis of fate determination are not yet clear. Among the available investigation systems, confocal fluorescence microscopy using fluorescent dyes enables the observation of cell function and shape at the subcellular scale in vital and fixed conditions. Contrarily, nonlinear optical microscopy techniques, which exploit multi-photon processes, allow to study cell behavior in vital and unlabeled conditions. We apply confocal fluorescence microscopy, coherent anti-Stokes Raman scattering (CARS), and second harmonic generation (SHG) microscopy to characterize the phenotypic expression of mesenchymal stem cells (MSCs) towards adipogenic and chondrogenic differentiation inside Nichoid scaffolds, in terms of nuclear morphology and specific phenotypic products, by comparing these techniques. We demonstrate that the Nichoid maintains a rounded nuclei during expansion and differentiation, promoting MSCs adipogenic differentiation while inhibiting chondrogenesis. We show that CARS and SHG techniques are suitable for specific estimation of the lipid and collagenous content, thus overcoming the limitations of using unspecific fluorescent probes.     

Advanced mask aligner lithography (AMALITH) for thick photoresist

Advanced mask aligner lithography (AMALITH) is a holistic approach to improve shadow printing (contact and proximity lithography) in mask aligners. AMALITH is based on two tools, the MO Exposure Optics^®, a new illumination system allow shaping the angular spectrum of the illumination light, and LAB, a software tool for full 3D simulation of the shadow printing process. MO Exposure Optics^® is provided by SUSS MicroTec AG (http://www.suss.com), as an upgrade for all current and older mask aligner models. MO Exposure Optics^® decouples the illumination from lamp misplacement (self-calibrated light source), improves the light uniformity, provides telecentric illumination and enables customized illumination in mask aligners. LAB is a software tool provided by GenISys GmbH (http://www.genisys-gmbh.com), and allows simulating the complete chain from illumination, mask pattern, photoresist and resist processing. The combination of both tools allows optimizing mask aligner lithography beyond today’s limits.     

Moving GeoPQL: a pictorial language towards spatio-temporal queries

Nowadays, two of the main challenges involving spatio-temporal databases concern the integration of their spatial and temporal features to store and query spatial objects changing over time, and the development of a simple and friendly language to query spatio-temporal data. In this paper we gather these two challenges by proposing Moving GeoPQL, a language defined in order to express spatio-temporal queries, extending the Geographical Pictorial Query language (GeoPQL). The proposed evolution is based on the concept of temporal layer that allows specifying the spatial configuration of moving objects in a time interval. More layers allow representing changes in terms of spatial configurations. Some examples of query formulation and system operation are described in the article. Finally, an experiment has been carried out for evaluating the usability of the Moving GeoPQL system. Results of this experiment showed that it facilitates the spatio-temporal query formulation since it is more user-friendly and ease to use compared to textual query languages.