J. Rager  A. Flaig  G. Schneider  T. Kaiser  F. Soldera  F. Mücklich 《Advanced Engineering Materials》2005,7(7):633-640

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Armin Paar  Reinhold Schneider  Peter Zeller  Gerhard Reiter  Stefan Paul  Paul Würzinger 《国际钢铁研究》2014,85(4):570-578

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FM Hecht  J Wheat  AH Korzun  R Hafner  KJ Skahan  R Larsen  MT Limjoco  M Simpson  D Schneider  MC Keefer  R Clark  KK Lai  JM Jacobson  K Squires  JA Bartlett  W Powderly 《Canadian Metallurgical Quarterly》1997,16(2):100-107

The expression of cytokeratins (CKs) in normal cervical epithelium, low grade squamous intraepithelial lesions (SIL), high grade SILs and squamous cell carcinoma (SCC) were analyzed using four different monoclonal antikeratin antibodies. In normal cervical epithelium, CK 18 showed strong immunoreactivity in basal and parabasal layers. CK 19 and 14 were expressed only in the basal layer while CK 13 was found selectively n the spinal cells. As the lesions progressed from low grade SIL to high grade SIL, immunoreactivity of CK 18, 19 and 14 in the basal cell compartment increased while the expression of CK 13 decreased. In SCC, as well-differentiated tumors showed decreased immunoreactivity for CK 18, 19 and 14 with CK 13 showing a strong and focal (localized) immunoreactivity. Undifferentiated carcinomas totally lacked CK 13 reactivity. Our findings therefore suggest that expression of CK 18, 19 and 14 may be directly related to tumor grade and CK 13 may be a marker of differentiation in cervical lesions.  相似文献   

    

Currin  James B.; Hayslip  Bert  Jr.; Schneider  Lawrence J.; Kooken  Robert A. 《Canadian Metallurgical Quarterly》1998,35(4):506

In order to investigate historical shifts in attitudes toward mental health and mental health services, two independent samples of older adults separated by a 14-year time interval were administered questionnaires. There were 91 in the 1977 sample (mean age 69.91 yrs) and 116 in the 1991 sample (mean age 71.94 yrs). Four newly created, internally consistent scales assessed multiple dimensions of their mental health attitudes (breadth of conceptions, bias, openness to help, range of problems). Analyses suggested that the younger cohorts of older adults held more positive attitudes toward mental health and mental health services than the older cohorts. These cohort differences remained when controlled for age, level of education, self-reported health, and income. These data indicate a positive cohort shift in attitudes toward mental health, a finding with numerous implications for the design and implementation of mental health services for future cohorts of older persons. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

    

U Schaefer  A Schneider  D Rixen  E Neugebauer 《Canadian Metallurgical Quarterly》1998,47(6):256-264

OBJECTIVE AND DESIGN: In order to understand the underlying mechanism of histamine stimulated inflammatory responses, histamine receptor subtypes and signal transduction pathways by which histamine mediates the stimulation of neutrophil adhesion to endothelial cells has been studied in vitro. MATERIAL: Human neutrophils and human umbilical vein endothelial cells. TREATMENT: Confluent human endothelial cell layer were incubated with histamine (1 mM), H1, H2 or H3 receptor agonists: fluorophenylhistamine (10 microM), amthamine (10 microm), methylhistamine (10 microM), respectively. Ten minutes prior to histamine (1 mM) stimulation H1, H2 or H3 receptor antagonists (dimethindene, 100 microM; famotidine, 1OO microM, thioperamid 100 microM, respectively) were added. Histamine stimulated signal transduction pathways were inhibited by adding phospholipase C inhibitor 2-nitro-4-carboxyphenyl N,N-diphenylcarbamat (200 microM), adenylate cyclase inhibitor 9-(2 tetrahydrofuryl)adenine (80 microM), nitric oxide synthase isozymes inhibitor S-ethylisothiourea (1 microM) or guanylate cyclase inhibitor (LY 83583; 10 microM). Neutrophil adhesion was monitored at 30, 60, 90, 120, 150, 180 and 210 min. METHODS: Neutrophil adhesion to endothelial cells was quantified by analysing alkaline phosphatase activity. RESULTS: Histamine stimulation of endothelial cells resulted in a biphasic time and concentration dependent pattern of neutrophil adhesion. This pattern of neutrophil adhesion was mimicked by stimulation of endothelial cells with H1 or H2 agonists. Stimulation of endothelial cells with an H3 agonist had no effect on neutrophil binding. Inhibition of phospholipase C (PLC), nitric oxide synthase isozymes (NOS) or guanylate cyclase (GC) resulted in a significant decrease of neutrophil binding to histamine or agonist stimulated endothelial cells. An increase of neutrophil binding to unstimulated or to agonist stimulated endothelial cells was observed during inhibition of adenylate cyclase. CONCLUSIONS: Our results suggest that histamine stimulated neutrophil adhesion is due to H1 and H2 receptor mediated activation of PLC, NOS and GC. Increase of cAMP concentration seems to mediate an inhibitory effect on PMN adhesion to endothelial cells.  相似文献   

    

Taylor  Shelley E.; Kemeny  Margaret E.; Aspinwall  Lisa G.; Schneider  Stephen G.; Rodriguez  Richard; Herbert  Mark 《Canadian Metallurgical Quarterly》1992,63(3):460

In a cohort of gay men responding to the threat of AIDS, dispositional optimism was associated with less distress, less avoidant coping, positive attitudes as a coping strategy, and fewer AIDS-related concerns. Men who knew they were seropositive for HIV were significantly more optimistic about not developing AIDS than men who knew they were seronegative for HIV. This AIDS-specific optimism was related to higher perceived control over AIDS and to active coping among seropositive men only and to health behaviors in both serostatus groups. There was no relation of optimism to risk-related sexual behavior. It is concluded that optimism is psychologically adaptive without necessarily compromising health behavior. It is also concluded that it is useful to distinguish between event-based optimistic expectations and dispositional optimism. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

    

SM Kang  DB Schneider  Z Lin  D Hanahan  DA Dichek  PG Stock  S Baekkeskov 《Canadian Metallurgical Quarterly》1997,3(7):738-743

Fas ligand is believed to mediate immune privilege in a variety of tissues, including the eye, testis, and a subset of tumors. We tested whether expression of Fas ligand on pancreatic islets either following adenoviral or germline gene transfer could confer immune privilege after transplantation. Islets were infected with an adenoviral vector containing the murine Fas ligand cDNA (AdFasL), and were transplanted into allogenic diabetic hosts. Paradoxically, AdFasL-infected islets underwent accelerated neutrophilic rejection. The rejection was T cell and B cell independent and required Fas protein expression by host cells, but not on islets. Similarly, transgenic mice expressing Fas ligand in pancreatic beta cells developed massive neutrophilic infiltrates and diabetes at a young age. Thus, Fas ligand expression on pancreatic islets results in neutrophilic infiltration and islet destruction. These results have important implications for the development of Fas ligand-based immunotherapies.  相似文献   

    

JM Singer  MH Pedersen  T Schneider  H Beck  H Matuttis 《Canadian Metallurgical Quarterly》1996,54(2):1286-1301

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Schneider  Kirk J. 《Canadian Metallurgical Quarterly》1990,27(1):95

Suggests that a religious-existential (RE) understanding of compulsive eating serves as a useful adjunct to traditional forms of treatment for this disorder. The RE approach is suggested for patients who use compulsive eating as a maladaptive form of worship. This approach combines standard cognitive-behavioral (CB) techniques with introspective-exploratory (IE) interventions. Successful dieters derive initial benefit from CB interventions and follow-up benefit from IE interventions. Patients begin by identifying and altering dysfunctional habits and follow up by identifying and transforming the values underlying those habits. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

    

H Schneider  Kv Klitzing 《Canadian Metallurgical Quarterly》1988,38(9):6160-6165

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