The Potential of Adaptive Design in Animal Studies

Clinical trials are the backbone of medical research, and are often the last step in the development of new therapies for use in patients. Prior to human testing, however, preclinical studies using animal subjects are usually performed in order to provide initial data on the safety and effectiveness of prospective treatments. These studies can be costly and time consuming, and may also raise concerns about the ethical treatment of animals when potentially harmful procedures are involved. Adaptive design is a process by which the methods used in a study may be altered while it is being conducted in response to preliminary data or other new information. Adaptive design has been shown to be useful in reducing the time and costs associated with clinical trials, and may provide similar benefits in preclinical animal studies. The purpose of this review is to summarize various aspects of adaptive design and evaluate its potential for use in preclinical research.     

Scalable Fabrication of Metallic Nanofiber Network via Templated Electrodeposition for Flexible Electronics

Metallic nanofiber networks (MNFNs) are very promising for next‐generation flexible transparent electrodes (TEs) since they can retain outstanding optical and electrical properties during bending due to their ultralong and submicron profile. However, it is still challenging to achieve cost‐effective and high‐throughput fabrication of MNFNs with reliable and consistent performance. Here, a cost‐effective method is reported to fabricate high‐performance MNFN‐TEs via templated electrodeposition and imprint transfer. The fabricated electrodeposition template has a trilayer structure of glass/indium tin oxide/SiO₂ with nanotrenches in the insulating SiO₂ that can be utilized for repeated electrodeposition of the MNFNs, which are then transferred to flexible substrates. The fabricated TEs exhibit excellent optical transmittance (>84%) and electrical conductivity (<0.9 Ω sq^?1) and show desirable mechanical flexibility with a sheet resistance <2 Ω sq^?1 under a bending radius of 3 mm. Meanwhile, the MNFN‐TEs reproduced from the reusable template show consistent and reliable performance. Additionally, this template‐based method can realize the direct patterning of MNFN‐TEs with arbitrary conductive patterns by selective masking of the template. As a demonstration, a flexible dynamic electroluminescent display is fabricated using TEs made by this method, and the light‐emitting pattern is observable from both sides.     

Queue length‐based load balancing in data center networks

Traffic load balancing in data centers is an important requirement. Traffic dynamics and possibilities of changes in the topology (e.g., failures and asymmetries) make load balancing a challenging task. Existing end‐host–based schemes either employ the predominantly used ECN or combine it with RTT to get congestion information of paths. Both congestion signals, ECN and RTT, have limitations; ECN only tells whether the queue length is above or below a threshold value but does not inform about the extent of congestion; similarly, RTT in data center networks is on the scale of up to few hundreds of microseconds, and current data center operating systems lack fine‐grained microsecond‐level timers. Therefore, there is a need of a new congestion signal which should give accurate information of congestion along the path. Furthermore, in end‐host–based schemes, detecting asymmetries in the topology is challenging due to the inability to accurately measure RTT on the scale of microseconds. This paper presents QLLB, an end‐host–based, queue length–based load balancing scheme. QLLB employs a new queue length–based congestion signal that gives an exact measure of congestion along the paths. Furthermore, QLLB uses relative‐RTT to detect asymmetries in the topology. QLLB is implemented in ns‐3 and compared with ECMP, CONGA, and Hermes. The results show that QLLB significantly improves performance of short flows over the other schemes and performs within acceptable level, of CONGA and Hermes, for long flows. In addition, QLLB effectively detects asymmetric paths and performs better than Hermes under high loads.     

Fixed frequency sliding mode control of renewable energy resources in DC micro grid

The rising cost of fossil fuels, their high depleting rate and issues regarding environmental pollution have brought the attention of the researchers towards renewable energy technologies. Different renewable energy resources like wind turbines, fuel cells and solar cells are connected to DC micro grid through controllable power electronic converters. In presence of these diverse generation units, robust controllers are required to ensure good power quality and to regulate grid voltage. This paper presents a sliding mode control based methodology to address the above mentioned challenges. The proposed technique keeps the switching frequency constant so that electromagnetic compatibility (EMC) issues can be solved with conventional filter design. Parallel operation of converter in DC micro gird is considered. Chattering reduction and power quality improvement by harmonic cancellation is proposed. A scaled down hardware for unregulated 11.5 V to 17.5 V input and 24V output is designed and tested. The experimental results show good performance of the controller under different loads and uncertain input voltage conditions. Moreover, the results show the robustness of the closed loop system to sudden variations in load conditions. Furthermore, a significant improvement in power quality is achieved by harmonic cancellation of chattering in the output of the converters.     

A new rectangular window based image cropping method for generalization of brain neoplasm classification systems

Classification of brain neoplasm images is one of the most challenging research areas in the field of medical image processing. The main objective of this study is to design a brain neoplasm classification system that can be trained using multiple various sized MR images of different institutions. The proposed method is a generalized classification system; it can be used in a single institute or in a number of institutions at the same time, without any restriction on image size. The generalization and unbiased capability of the proposed method can bring researchers on a single platform to work on some standard forms of computer aided diagnosis system with more efficient diagnostic capabilities. In this study, a suitable size of moveable rectangular window is used between segmentation and feature extraction stages. A semiautomatic, localized region based active contour method is used for segmentation of brain neoplasm region. Discrete wavelet transform for feature extraction, principal component analysis for feature selection and support vector machine is used as classifier. For the first time MR images of 2 sizes and from different institutions are used in training and testing of brain neoplasm classifier. Three glioma grades were classified using 92 MR images. The proposed method achieved the highest accuracy of 88.26%, the highest sensitivity of 92.23% and the maximum specificity of 93.93%. In addition, the proposed method is computationally less complex, requires shorter processing time and is more efficient in terms of storage capacity.     

An efficient ontology-based topic-specific article recommendation model for best-fit reviewers

Scientometrics - In general peer review is accredited as the vital and utmost cornerstone of the scientific publishing and research developments. Undeniably, the reviewers play a decisive role in...     

A Highly Secured Image Encryption Scheme using Quantum Walk and Chaos

The use of multimedia data sharing has drastically increased in the past few decades due to the revolutionary improvements in communication technologies such as the 4th generation (4G) and 5th generation (5G) etc. Researchers have proposed many image encryption algorithms based on the classical random walk and chaos theory for sharing an image in a secure way. Instead of the classical random walk, this paper proposes the quantum walk to achieve high image security. Classical random walk exhibits randomness due to the stochastic transitions between states, on the other hand, the quantum walk is more random and achieve randomness due to the superposition, and the interference of the wave functions. The proposed image encryption scheme is evaluated using extensive security metrics such as correlation coefficient, entropy, histogram, time complexity, number of pixels change rate and unified average intensity etc. All experimental results validate the proposed scheme, and it is concluded that the proposed scheme is highly secured, lightweight and computationally efficient. In the proposed scheme, the values of the correlation coefficient, entropy, mean square error (MSE), number of pixels change rate (NPCR), unified average change intensity (UACI) and contrast are 0.0069, 7.9970, 40.39, 99.60%, 33.47 and 10.4542 respectively.     

Adaptive Fuzzy Logic Controller for Harmonics Mitigation Using Particle Swarm Optimization

An excessive use of non-linear devices in industry results in current harmonics that degrades the power quality with an unfavorable effect on power system performance. In this research, a novel control technique-based Hybrid-Active Power-Filter (HAPF) is implemented for reactive power compensation and harmonic current component for balanced load by improving the Power-Factor (PF) and Total–Hormonic Distortion (THD) and the performance of a system. This work proposed a soft-computing technique based on Particle Swarm-Optimization (PSO) and Adaptive Fuzzy technique to avoid the phase delays caused by conventional control methods. Moreover, the control algorithms are implemented for an instantaneous reactive and active current (I_d-I_q) and power theory (Pq0) in SIMULINK. To prevent the degradation effect of disturbances on the system's performance, PS0-PI is applied in the inner loop which generate a required dc link-voltage. Additionally, a comparative analysis of both techniques has been presented to evaluate and validate the performance under balanced load conditions. The presented result concludes that the Adaptive Fuzzy PI controller performs better due to the non-linearity and robustness of the system. Therefore, the gains taken from a tuning of the PSO based PI controller optimized with Fuzzy Logic Controller (FLC) are optimal that will detect reactive power and harmonics much faster and accurately. The proposed hybrid technique minimizes distortion by selecting appropriate switching pulses for VSI (Voltage Source Inverter), and thus the simulation has been taken in SIMULINK/MATLAB. The proposed technique gives better tracking performance and robustness for reactive power compensation and harmonics mitigation. As a result of the comparison, it can be concluded that the PSO-based Adaptive Fuzzy PI system produces accurate results with the lower THD and a power factor closer to unity than other techniques.     

Theoretical Investigations of Magnetic Properties and Mechanical Stability of Quaternary Heusler Compounds FeYCrZ (Z = Al,Ga, Ge,and Si): a Spin Gapless Semiconductor

Journal of Superconductivity and Novel Magnetism - In this work, full potential linearized augmented plane wave (FP-LAPW) method is used to determine the electronic, magnetic, and mechanical...     

A Review on the Security of the Internet of Things: Challenges and Solutions

The Internet of Things (IoT) has emerged as a modern wave of Internet technologies that promises great transformation of life in areas such as smart health, smart cities, smart homes, intelligent transport, amongst others. However, security often serves as a critical reason for the widespread adoption of any innovation. While the IoT has increased business productivity and enriched diverse areas of life over the years, the world is yet to see a methodical revolution of its humongous application and transformation given its ubiquity and highly interconnected global network structure. The main culprit for such lapses is principally attributed to security and privacy issues which have been widely discussed in research articles and reviews but remain largely unaddressed in the literature. Hence, this paper provides a state-of-the-art review of IoT security and its challenges. It overviews technical and legal solutions that are useful to private, organizational, and governmental enterprises. The study encompasses the review and security analysis of IoT’s evolution and revolution, IoT security assessments, requirements, current research challenges in security and much more. Consequently, it offers potential solutions to address the security challenges discussed and further present open research issues, research gaps, opportunities, future development, and recommendations. This overview is intended to serve as a knowledgebase that will proffer novel foresight to guide users and administrators in positioning themselves and their organizations in a manner that is consistent with their overall objectives, mission, and vision for remarkable outcomes. Likewise, interested scholars and researchers can explore topics and directions from the study in providing better solutions to the numerous problems in IoT security.