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11.
The previously published report suggests that liposomes, functionalized with annexin‐5, can deliver bevacizumab to the retina after topical administration as eyedrops. Topical delivery of bevacizumab would be an attractive alternative to the current treatment that involves monthly intravitreal injections to the eye. In this Comment, the retinal concentrations of topically applied liposomal bevacizumab are compared to the levels reached after intravitreal injections. The comparison reveals that the topical liposomal delivery results in retinal bevacizumab concentrations that are about 3–5 orders of magnitude below the lowest bevacizumab concentrations during clinical treatment with intravitreal injections. Major improvement is needed before topical bevacizumab delivery can be considered clinically feasible. 相似文献
12.
S Gabriel A Kivi A Eilers R Kovács U Heinemann 《Canadian Metallurgical Quarterly》1998,9(11):2583-2587
Immature glia may not be able to buffer K+ ions released during neuronal activity. Therefore, we investigated entorhinal-hippocampal slices of juvenile rats (ages P15-18 and P22-26) using a perfusion medium containing 2 mM BaCl2 in order to block glial inward rectifying and leak potassium channels. In contrast to adult animals, rises in [K+]o in slices from juvenile animals elicited by repetitive alvear stimulation were not augmented by Ba2+. Ba2+ effects on fast field potentials, slow field potentials and the applied current sink source distribution were roughly similar as in adult rats. We conclude that the capacity to buffer large quantities of K+ ions by mechanisms involving Ba2+-sensitive K+ channels has not yet developed in juveniles. 相似文献
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14.
Markku Åberg Arto Rantala Helena Pohjonen 《Analog Integrated Circuits and Signal Processing》1998,15(2):143-151
A 16 input and 16 output channels single chip intermediate frequency range (160 MHz) analog switch matrix for personal communication satellites has been designed and processed by using a commercial 1.2 µm BiCMOS technology. The circuit has low power consumption (,2W) and low insertion loss with maximum output power of 0 dBm. 相似文献
15.
In this study, the ozone gas-liquid mass transfer into water in a bubble column was investigated for different pH values. The ozone volumetric mass transfer coefficient and the Henry's coefficient were determined simultaneously by parameter estimation using a nonlinear optimization method. A sensitivity analysis was conducted to obtain information on the reliability and identifiability of the estimated parameters. A minor dependence of the Henry's law constant on pH was detected at the pH range 4 to 9. 相似文献
16.
Marja-Riitta Kivi Tapio Gr nfors Antti Koponen 《Behaviour & Information Technology》1998,17(3):152-154
This paper describes an efficient technique to record display output stream with memory resident software. This kind of recording can be made useful for studying text writing processes experimentally, for example programmers behaviour during coding. The system is inconspicuous in test situation and does not seem to affect the testees working. Separate software has been developed for reviewing captured sessions. 相似文献
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Johansson Lasse Koivo Heikki N. Peltomaa Arto S. 《Industrial Electronics, IEEE Transactions on》1984,(3):263-268
A design of an industrial microcomputer control system for a 1.6-MW boiler using solid fuel is presented. Instrumentation and control philosophies for the boiler are discussed. The microcomputer system is based on standard iSBC microcomputer boards. The software consists of a real-time operating system RXM/80 and application tasks. The designed control system saves fuel and gives a more reliable over-all operation. 相似文献
19.
Evaluation of the hot-carrier-induced offset voltage of differential pairs in analogue CMOS circuits
Roland Thewes Michael J. Kivi Karl F. Goser Werner Weber 《Quality and Reliability Engineering International》1995,11(4):273-277
Using a specifically developed measurement set-up and a test structure typical for analogue applications, high precision measurements of the stress-induced offset voltage degradation of differential pairs are presented. Extrapolation to operating conditions yields valuable information for analogue design in the sub-micron CMOS regime. 相似文献
20.
M Bastida Eizaguirre MJ Arto Urzainqui R Iturbe Ortiz de Urbina 《Canadian Metallurgical Quarterly》1996,44(4):402-404
A 43-year-old white man with a history of cigarette smoking, hypertension, nephrolithiasis, and cervical degenerative arthritis was hospitalized for sudden-onset severe, substernal, and pleuritic chest pain with epigastric radiation. Despite evaluation, the cause remained unclear and the patient expired on hospital day 5. Autopsy revealed acute Stanford type A aortic dissection, hemopericardium, and hemothorax. Grossly, the aorta and its branches, including uninvolved medium-sized arteries, displayed extreme mural fragility. Microscopic examination showed a primary lymphoplasmacytic aortitis-periaortitis without giant cells. Rents within the tunica media, medial-adventitial inflammation, and elastic fiber disruption were limited to sites of gross aortic dissection. Muscular arteries showed patchy, chronic arteritis-periarteritis without giant cell infiltrate or aneurysm formation. This case documents an unusual association of primary lymphoplasmacytic aortitis and aortic dissection. 相似文献