Can anti-HLA antibody analyses postcardiac transplantation predict acute allograft rejection and survival?

The immunosuppressive agent FK 506 is widely used in liver transplant patients. Neurotoxicity is a major complication of its use. We report progressive and irreversible neurologic complications occurring in a 39-year-old woman who underwent liver transplantation and was treated with FK 506. Neuropathologic examination revealed multiple vasculitic lesions. The possibility of an FK 506-mediated toxic effect on the cerebral vessels is suggested.     

Point-based manifold harmonics

This paper proposes an algorithm to build a set of orthogonal Point-Based Manifold Harmonic Bases (PB-MHB) for spectral analysis over point-sampled manifold surfaces. To ensure that PB-MHB are orthogonal to each other, it is necessary to have symmetrizable discrete Laplace-Beltrami Operator (LBO) over the surfaces. Existing converging discrete LBO for point clouds, as proposed by Belkin et al. [CHECK END OF SENTENCE], is not guaranteed to be symmetrizable. We build a new point-wisely discrete LBO over the point-sampled surface that is guaranteed to be symmetrizable, and prove its convergence. By solving the eigen problem related to the new operator, we define a set of orthogonal bases over the point cloud. Experiments show that the new operator is converging better than other symmetrizable discrete Laplacian operators (such as graph Laplacian) defined on point-sampled surfaces, and can provide orthogonal bases for further spectral geometric analysis and processing tasks.     

Triple Metal Surrounding Gate Junctionless Tunnel FET Based 6T SRAM Design for Low Leakage Memory System

Silicon - The promising capability of Triple Material Surrounding Gate Junctionless Tunnel FET (TMSG – JL – TFET) based 6 T SRAM structure is demonstrated by employing...     

Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis

Cell division cycle 25A (Cdc25A) is a dual-specificity phosphatase that is overexpressed in several cancer cells and promotes tumorigenesis. In normal cells, Cdc25A expression is regulated tightly, but the changes in expression patterns in cancer cells that lead to tumorigenesis are unknown. In this study, we showed that ubiquitin-specific protease 29 (USP29) stabilized Cdc25A protein expression in cancer cell lines by protecting it from ubiquitin-mediated proteasomal degradation. The presence of USP29 effectively blocked polyubiquitination of Cdc25A and extended its half-life. CRISPR-Cas9-mediated knockdown of USP29 in HeLa cells resulted in cell cycle arrest at the G0/G1 phase. We also showed that USP29 knockdown hampered Cdc25A-mediated cell proliferation, migration, and invasion of cancer cells in vitro. Moreover, NSG nude mice transplanted with USP29-depleted cells significantly reduced the size of the tumors, whereas the reconstitution of Cdc25A in USP29-depleted cells significantly increased the tumor size. Altogether, our results implied that USP29 promoted cell cycle progression and oncogenic transformation by regulating protein turnover of Cdc25A.     

Mössbauer study of the thermal decomposition of FeS2 in coal

The Mössbauer effect has been used to study the transformations of FeS₂ in four different coals: IL No. 6, Ky $\text{9}\text{14}$, Blacksville No. 2, and Powhatan No. 5. The transformations of FeS₂ in the coals were studied in an inert atmosphere. It was observed that the pyrrhotites formed from FeS₂ have a considerable reduction in the isomer shift at 440 °C as compared to the values obtained in the absence of coal. This effect is associated with the interaction of the pyrrhotites with the coal constituents at high temperatures. There is also a significant line-broadening at 440 °C. This broadening is due either to vacancy motion in the iron sulphides and/or to motional broadening due to particle motion in the coal-derived liquids. The percentage conversion of pyrite to pyrrhotite depends markedly on time as well as type of coal. The weathering of the coal has a detrimental effect on the rate of conversion of pyrite to pyrrhotite. The ferrous sulphate layers covering the pyrite particles hinder the removal of sulphur from that surface. The major factor affecting the $\text{Fe}\text{S}$ ratio is the total amount of sulphur available for H₂S formation. Partial H₂S pressure is the crucial quantity controlling the stoichiometry of the pyrrhotites. Hence, a high percentage of H₂S in the reactor at high temperature will assure the formation of pyrrhotites with a high number of metal vacancies.     

Moisture Distribution and Dewatering Efficiency for Wet Materials

This review paper summarizes current research efforts toward a comprehensive view of wet material dewatering, considering the binding energy as the strength to hold water, and rupture energy given to remove moisture from materials.     

Analysis of the diffusion layer thickness, equivalent circuit and conductance behaviour for reversible electron transfer processes in linear sweep voltammetry

The parametric dependence of the diffusion layer thickness upon electrode potential and scan rate has been derived for reversible electron transfer processes in linear sweep voltammetry (LSV) using a simple analytical expression for the dimensionless current function. The quantitative variation of the conductance with potential and scan rate has been illustrated and the equivalent circuit pertaining to LSV has been proposed. Several earlier results pertaining to potential step experiments, thin layer voltammetry, surface bound LSV, radial flow at micro-ring electrodes, etc. are shown to arise from the general expression for the current function obtained here, thus indicating an isomorphism among various potential perturbation techniques.     

Psychophysical basis for maximum pushing and pulling forces: A review and recommendations

The objective of this paper was to perform a comprehensive review of psychophysically determined maximum acceptable pushing and pulling forces. Factors affecting pushing and pulling forces are identified and discussed. Recent studies show a significant decrease (compared to previous studies) in maximum acceptable forces for males but not for females when pushing and pulling on a treadmill. A comparison of pushing and pulling forces measured using a high inertia cart with those measured on a treadmill shows that the pushing and pulling forces using high inertia cart are higher for males but are about the same for females. It is concluded that the recommendations of Snook and Ciriello (1991) for pushing and pulling forces are still valid and provide reasonable recommendations for ergonomics practitioners. Regression equations as a function of handle height, frequency of exertion and pushing/pulling distance are provided to estimate maximum initial and sustained forces for pushing and pulling acceptable to 75% male and female workers.