Mostafa Noohi;Adel Pourmand;Habib Badri Ghavifekr;Ali Mirvakili; 《ETRI Journal》2024,46(4):581-594

In this study, a planar printed circuit board (PCB) coil with FR4 substrate was designed and simulated using the finite element method, and the results were analyzed in the frequency domain. This coil can be used in wireless power transfer (WPT) as a transmitter or receiver, eliminating wires. It can also be used as the receiver in radio frequency energy-harvesting (RF-EH) systems by optimizing the planar PCB coil to convert radio-wave energy into electricity, and it can be employed as an excitation (transmitter) or receiver coil in nuclear magnetic resonance (NMR) spectroscopy. This PCB coil can replace the conventional coil, yielding a reduced occupied volume, a fine-tuned design, reduced weight, and increased efficiency. Based on the calculated gain, power, and electromagnetic and electric field results, this planar PCB coil can be implemented in WPT, NMR spectroscopy, and RF-EH devices with minor changes. In applications such as NMR spectroscopy, it can be used as a transceiver planar PCB coil. In this design, at frequencies of 915 MHz and 40 MHz with 5 mm between coils, we received powers of 287.3 W and 480 W, respectively, which are suitable for an NMR coil or RF-EH system.  相似文献   

    

Asmaa Abdullah Salem  Hanan Abdullah Al Amoudi 《Journal of Natural Fibers》2020,17(4):491-504

ABSTRACT

We investigate the dyeing and antimicrobial properties of myrrh (Commiphora molmol) extracts on wool and silk fabrics, the use of eco-friendly materials such as sumac (Rhus coriaria), manjakani (Quercus infectoria), alum, and ferrous sulfate as mordants. The mordanting methods were optimized.

The best conditions of dyeing process were discussed in the first part of this study. Dyed fabrics were assessed for color strength (K/S), color fastness, and antimicrobial activity. Non-mordanted dyed wool and silk showed color fastness of grade 4–5. Dyed fabrics showed good antimicrobial activity, which was enhanced by mordanting.  相似文献   

    

Marwa Khmaissa  Bilel Hadrich  Mohamed Chamkha  Adel Sayari  Ahmed Fendri 《Journal of surfactants and detergents》2022,25(3):361-376

The aim of this work was to optimize the production of a new lipase by a halotolerant bacterial strain Halomonas sp. C2SS100, by means of the response-surface methodology (RSM). The process parameters having the most significant effect on lipase production were identified using the Plackett–Burman screening design-of-experiments. Then, Box–Behnken design was applied to optimize lipase activity and the quadratic regression model of the lipase production was built. Indeed, the lipase yield was increased, and the value obtained experimentally (39 ± 2 U/ml) was very close to the rate predicted by the model (40.3 U/ml). Likewise, optimization of parameters by RSM resulted in 2.78-fold increase in lipase activity. These findings provide the first report on lipase production and optimization by a halotolerant bacterial strain belonging to Halomonas genus. Afterward, the biochemical properties of the produced lipase were studied for apply in oil stains removal. The crude lipase showed a maximum activity at 60°C and at pH ranging from 7 to 10. It displayed an important stability at high temperature, pH, and NaCl. Interestingly, this bacterial lipase exhibited a prominent stability toward some commercial solid and liquid detergents after 30 min of incubation at 50°C. The capability of the crude lipase to eliminate stain was ascertained on polycotton fabric pieces stained with lubricating oil. Whether with the addition of hot water alone or of a commercially available detergent, lipase is able to considerably boost the elimination of oil stains. The actual findings highlight the capacity of Halomonas sp. lipase for energy-efficient biocatalytic application.  相似文献   

    

Asmaa M. Abu El-Soad  Giuseppe Lazzara  Mahmoud O. Abd El-Magied  Giuseppe Cavallaro  Jamelah S. Al-Otaibi  M. I. Sayyed  Elena G. Kovaleva 《International journal of molecular sciences》2022,23(4)

The modification of chitosan represents a challenging task in obtaining biopolymeric materials with enhanced removal capacity for heavy metals. In the present work, the adsorption characteristics of chitosan modified with carboxyl groups (CTS-CAA) towards copper (II) and zinc (II) ions have been tested. The efficacy of the synthesis of CTS-CAA has been evaluated by studying various properties of the modified chitosan. Specifically, the functionalized chitosan has been characterized by using several techniques, including thermal analyses (differential scanning calorimetry and thermogravimetry), spectroscopies (FT-IR, XRD), elemental analysis, and scanning electron microscopy. The kinetics and the adsorption isotherms of CTS-CAA towards both Cu (II) and Zn (II) have been determined in the aqueous solvent under variable pH. The obtained results have been analyzed by using different adsorption models. In addition, the experiments have been conducted at variable temperatures to explore the thermodynamics of the adsorption process. The regeneration of CTS-CAA has been investigated by studying the desorption process using different eluents. This paper reports an efficient protocol to synthesize chitosan-based material perspective as regenerative adsorbents for heavy metals.  相似文献   

    

Maria A. Ortiz  F. Javier Piedrafita  Adel Nefzi 《International journal of molecular sciences》2022,23(8)

A growing body of evidence suggests a pathogenic role for pro-inflammatory T helper 17 cells (Th17) in several autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, type I diabetes, and psoriasis—diseases for which no curative treatment is currently available. The nuclear retinoic acid receptor–related orphan receptors alpha and gamma (RORα/γ), in particular the truncated isoform RORγt that is specifically expressed in the thymus, play a critical role in the activation of a pro-inflammatory Th17 response, and RORγ inverse agonists have shown promise as negative regulators of Th17 for the treatment of autoimmune diseases. Our study underscores the screening of a large combinatorial library of 1,5-disubstituted acylated 2-amino-4,5-dihydroimidazoles using a demonstrated synthetic and screening approach and the utility of the positional scanning libraries strategy for the rapid identification of a novel class of ROR inhibitors. We identified compound 1295-273 with the highest activity against RORγ (3.3 µM IC₅₀) in this series, and almost a two-fold selectivity towards this receptor isoform, with 5.3 and 5.8 µM IC₅₀ against RORα and RORβ cells, respectively.  相似文献   

    

Asmaa Anwar Ismail  Baraah Tariq Shaker  Khalid Bajou 《International journal of molecular sciences》2022,23(1)

Angiogenesis is a process associated with the migration and proliferation of endothelial cells (EC) to form new blood vessels. It is involved in various physiological and pathophysiological conditions and is controlled by a wide range of proangiogenic and antiangiogenic molecules. The plasminogen activator–plasmin system plays a major role in the extracellular matrix remodeling process necessary for angiogenesis. Urokinase/tissue-type plasminogen activators (uPA/tPA) convert plasminogen into the active enzyme plasmin, which in turn activates matrix metalloproteinases and degrades the extracellular matrix releasing growth factors and proangiogenic molecules such as the vascular endothelial growth factor (VEGF-A). The plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of uPA and tPA, thereby an inhibitor of pericellular proteolysis and intravascular fibrinolysis, respectively. Paradoxically, PAI-1, which is expressed by EC during angiogenesis, is elevated in several cancers and is found to promote angiogenesis by regulating plasmin-mediated proteolysis and by promoting cellular migration through vitronectin. The urokinase-type plasminogen activator receptor (uPAR) also induces EC cellular migration during angiogenesis via interacting with signaling partners. Understanding the molecular functions of the plasminogen activator plasmin system and targeting angiogenesis via blocking serine proteases or their interactions with other molecules is one of the major therapeutic strategies scientists have been attracted to in controlling tumor growth and other pathological conditions characterized by neovascularization.  相似文献   

    

Reham Hammad  Reda Badr Aglan  Shaymaa A. Mohammed  Eman Abu-elnasr Awad  Marwa A. Elsaid  Hanan M. Bedair  Seham K. Khirala  Mohamed A Selim  Asmaa A. Abo Elqasem  Areej Rushdi  Mohamed Ali  Omaima I. Abo-Elkheir  Eman F. Sanad  Nadia M. Hamdy 《International journal of molecular sciences》2022,23(20)

Virus-related hepatocellular carcinoma (HCC) pathogenesis involves liver inflammation, therefore, despite successful treatment, hepatitis C virus (HCV) may progress to HCC from initiated liver cirrhosis. Cytotoxic T cells (Tcs) are known to be involved in HCV-related cirrhotic complications and HCC pathogenesis. The inhibitory checkpoint leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is expressed on Tcs. Therefore, we aimed to determine whether the Tc expression level of LAIR-1 is associated with HCC progression and to evaluate LAIR-1 expression as a noninvasive biomarker for HCC progression in the context of liver cirrhosis related to HCV genotype 4 (G4) in Egyptian patients’ peripheral venous blood liquid biopsy. A total of 64 patients with HCC and 37 patients with liver cirrhosis were enrolled in this case-controlled study, and their LAIR-1 expression on Tc related to the progression of liver cirrhosis was examined and compared to that of the apparently healthy control group (n = 20). LAIR-1 expression was analyzed using flow cytometry. Results: The HCC group had significantly higher LAIR-1 expression on Tc and percentage of Tc positive for LAIR-1 (LAIR-1+Tc%) than the HCV G4-related liver cirrhosis group. LAIR-1+Tc% was correlated with the HCC surrogate tumor marker AFP (r = 0.367, p = 0.001) and insulin resistance and inflammation prognostic ratios/indices. A receiver operating characteristic (ROC) curve revealed that adding LAIR-1+Tc% to AFP can distinguish HCC transformation in the Egyptian patients’ cohort. Upregulated LAIR-1 expression on Tc could be a potential screening noninvasive molecular marker for chronic inflammatory HCV G4 related liver cirrhosis. Moreover, LAIR-1 expression on Tc may be one of the players involved in the progression of liver cirrhosis to HCC.  相似文献   

    

Yosra Mlayeh  Fatma Rouissi  Fethi Tlili  Adel Ghazel 《Concurrency and Computation》2021,33(1)

In this article, we propose a new criterion for a switching algorithm to be used in MIMO‐OFDM systems. The switching algorithm, which selects between spatial multiplexing and MIMO diversity using the Demmel condition number as selection metrics, is first analyzed. Then, we show the limitation of this criterion, when increasing the receive antenna number. As a solution, we propose multiantenna processing and SNR switching criterion as a novel selection metric. The channel between the transmitter and the receiver is assumed a Rayleigh‐fading channel. Simulations results show that the proposed switching algorithm improves the performances in terms of bit error rate (BER) for symmetric and asymmetric MIMO systems. The gain is about 3 dB at BER = 10⁻⁴ in (4×4) architecture and 2 dB at BER = 10⁻⁴ in (3×2) architecture.  相似文献   

    

Dr. Markella Konstantinidou  Asmaa Oun  Pragya Pathak  Bidong Zhang  Zefeng Wang  Frans ter Brake  Dr. Amalia M. Dolga  Dr. Arjan Kortholt  Dr. Alexander Dömling 《ChemMedChem》2021,16(6):959-965

Here we present the rational design and synthetic methodologies towards proteolysis-targeting chimeras (PROTACs) for the recently-emerged target leucine-rich repeat kinase 2 (LRRK2). Two highly potent, selective, brain-penetrating kinase inhibitors were selected, and their structure was appropriately modified to assemble a cereblon-targeting PROTAC. Biological data show strong kinase inhibition and the ability of the synthesized compounds to enter the cells. However, data regarding the degradation of the target protein are inconclusive. The reasons for the inefficient degradation of the target are further discussed.  相似文献   

    

Othman Echi;Adel Khalfallah;Dhaker Kroumi 《法国自动化、信息与运筹学；理论与应用信息》2022,56(0)

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